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Dbnl
Gene Detail
Symbol

Name
ID
Dbnl
drebrin-like
MGI:700006
Synonyms
ABP1, mAbp1, SH3P7
Feature Type
protein coding gene
Genetic Map
Chromosome 11
3.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:5788488-5800962 bp, + strand
From VEGA annotation of GRCm38

  12475 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8468  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Dbnl

Human
homologs
Human Homolog DBNL, drebrin-like
NCBI Gene ID 28988
neXtProt AC  NX_Q9UJU6
Human Synonyms  ABP1, HIP55, HIP-55, SH3P7
Human Chr (Location)  7p13; chr7:44044640-44061716 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(36) : Gene trapped(33) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Targeted mutation causes abnormal structure and function in organs including the spleen, heart and lungs. Vesicle transport is impaired in the brain and neurological impairment is observed.
 
Interactions
Dbnl interacts with 111 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process endocytosis, immune system process, ...
Component cell cortex, cell junction, ...
Function actin binding, actin filament binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (61)    Tissues (41)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 41
Northern blot 12
Western blot 8
cDNA source data(149)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(149) cDNA(149)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000005097 (Evidence)
Ensembl Gene ModelENSMUSG00000020476 (Evidence)
Entrez Gene13169 (Evidence)
UniGene256925
DFCITC1724629, TC1628587, TC1603637, TC1572122
DoTSDT.101405843, DT.110522320, DT.94246065, DT.91328514, DT.534215
NIA Mouse Gene IndexU012287
Consensus CDS ProjectCCDS24403.1, CCDS48746.1, CCDS48747.1
International Mouse Knockout Project StatusDbnl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005097 VEGA Gene Model | MGI Sequence Detail 12475 C57BL/6J ±  kb
transcript OTTMUST00000011398 VEGA | MGI Sequence Detail 1638 Not Applicable 
polypeptide OTTMUSP00000005312 VEGA | MGI Sequence Detail 436 Not Applicable 

For the selected sequences
All sequences(75) RefSeq(6) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(54 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002108 Actin-binding, cofilin/tropomyosin type
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000006297 drebrin-like protein
References
(Earliest) J:35786 Sparks AB, et al., Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins. Nat Biotechnol. 1996 Jun;14(6):741-4
(Latest) J:212168 Seeley-Fallen MK, et al., Actin-binding protein 1 links B-cell antigen receptors to negative signaling pathways. Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9881-6
All references(50)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory