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Dbnl
Gene Detail
Symbol

Name
ID
Dbnl
drebrin-like
MGI:700006
Synonyms
ABP1, mAbp1, SH3P7
Feature Type
protein coding gene
Genetic Map
Chromosome 11
3.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:5788488-5800962 bp, + strand
From VEGA annotation of GRCm38

  12475 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8468  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DBNL
Gene Tree: Dbnl

Human
homologs
DBNL, drebrin-like
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 28988
neXtProt AC: NX_Q9UJU6

Human Synonyms: ABP1, HIP55, HIP-55, SH3P7

Human Chr (Location): 7p13; chr7:44044640-44061716 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(36) : Gene trapped(33) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Targeted mutation causes abnormal structure and function in organs including the spleen, heart and lungs. Vesicle transport is impaired in the brain and neurological impairment is observed.
 
Interactions
Dbnl interacts with 111 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process endocytosis, immune system process, ...
Component cell cortex, cell junction, ...
Function actin binding, actin filament binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (61)    Tissues (41)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 41
Northern blot 12
Western blot 8
cDNA source data(149)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase dbnl    NEW 
Molecular
reagents
All nucleic(149) cDNA(149)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000005097 (Evidence)
Ensembl Gene Model ENSMUSG00000020476 (Evidence)
Entrez Gene 13169 (Evidence)
UniGene 256925
DFCI TC1572122, TC1603637, TC1724629, TC1628587
DoTS DT.94246065, DT.91328514, DT.534215, DT.110522320, DT.101405843
NIA Mouse Gene Index U012287
Consensus CDS Project CCDS24403.1, CCDS48746.1, CCDS48747.1
International Mouse Phenotyping Consortium Status Dbnl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005097 VEGA Gene Model | MGI Sequence Detail 12475 C57BL/6J ±  kb
transcript OTTMUST00000011398 VEGA | MGI Sequence Detail 1638 Not Applicable 
polypeptide OTTMUSP00000005312 VEGA | MGI Sequence Detail 436 Not Applicable 

For the selected sequences
All sequences(77) RefSeq(6) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(54 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002108 Actin-binding, cofilin/tropomyosin type
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000006297 drebrin-like protein
References
(Earliest) J:35786 Sparks AB, et al., Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins. Nat Biotechnol. 1996 Jun;14(6):741-4
(Latest) J:212168 Seeley-Fallen MK, et al., Actin-binding protein 1 links B-cell antigen receptors to negative signaling pathways. Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9881-6
All references(48)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory