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Exoc2 Gene Detail
Summary
  • Symbol
    Exoc2
  • Name
    exocyst complex component 2
  • Synonyms
    2410030I24Rik, Sec5, Sec5l1
Location &
Maps
more
  • Sequence Map
    Chr13:30972939-31162082 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 13, Syntenic
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    962 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913732
protein coding gene Chr13:30968416-31162082 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020417
protein coding gene Chr13:28700030-28869068 (-)
A/J MGP_AJ_G0020372
protein coding gene Chr13:27958020-28119400 (-)
AKR/J MGP_AKRJ_G0020349
protein coding gene Chr13:28563991-28724834 (-)
BALB/cJ MGP_BALBcJ_G0020367
protein coding gene Chr13:28041953-28174779 (-)
C3H/HeJ MGP_C3HHeJ_G0020170
protein coding gene Chr13:28577323-28741902 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020803
protein coding gene Chr13:29684617-29850348 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018394
protein coding gene Chr13:26354377-26515058 (-)
CAST/EiJ MGP_CASTEiJ_G0019687
protein coding gene Chr13:28230636-28393737 (-)
CBA/J MGP_CBAJ_G0020126
protein coding gene Chr13:30944148-31130585 (-)
DBA/2J MGP_DBA2J_G0020248
protein coding gene Chr13:27489856-27650786 (-)
FVB/NJ MGP_FVBNJ_G0020233
protein coding gene Chr13:27093253-27254236 (-)
LP/J MGP_LPJ_G0020325
protein coding gene Chr13:28942210-29107716 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020259
protein coding gene Chr13:31090777-31261295 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020844
protein coding gene Chr13:28206291-28379781 (-)
PWK/PhJ MGP_PWKPhJ_G0019442
protein coding gene Chr13:27644411-27808275 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019263
protein coding gene Chr13:27119073-27285722 (-)
WSB/EiJ MGP_WSBEiJ_G0019749
protein coding gene Chr13:28516205-28680314 (-)



Homology
more
  • Human Ortholog
    EXOC2, exocyst complex component 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EXOC2, exocyst complex component 2
  • Synonyms
    NEDFACH, SEC5, SEC5L1, Sec5p
  • Links
    NCBI Gene ID: 55770
    neXtProt AC: NX_Q96KP1
    UniProt: Q96KP1

  • Chr Location
    6p25.3; chr6:485154-693139 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show complete embryonic lethality between implantation and somite formation and failure of blastocysts to hatch from the zona pellucida with increased cell death during outgrowth culture.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 66482 NCBI Gene Model | MGI Sequence Detail 189144 C57BL/6J ±  kb
transcript NM_001424702 RefSeq | MGI Sequence Detail 8099 C57BL/6  
polypeptide Q9D4H1 UniProt | EBI | MGI Sequence Detail 924 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 85
    cDNA 81
    Primer pair 3
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGI:2145277, MGI:5588834
References
more
  • Summaries
    All 54
    Developmental Gene Expression 6
    Gene Ontology 10
    Phenotypes 18
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory