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Hand2os1 Gene Detail
Summary
  • Symbol
    Hand2os1
  • Name
    Hand2, opposite strand 1
  • Synonyms
    AV026068, Gm28063, Hand2-as1, Uph, upperhand
Location &
Maps
more
  • Sequence Map
    Chr8:57304414-57320859 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, Syntenic
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    154 from dbSNP Build 142
  • Strain Annotations
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_5578769
antisense lncRNA gene Chr8:57281117-57324233 (-)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozgyous for a knock-out allele exhibit pericardial effusion, growth restriction, absent right ventricle, single left-sided ventricle and embryonic lethality.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 102636514 NCBI Gene Model | MGI Sequence Detail 16446 C57BL/6J ±  kb
    transcript NR_154048 RefSeq | MGI Sequence Detail 806 C57BL/6  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 10
      Primer pair 2
      Other 1

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:2142734
    References
    more
    • Summaries
      All 15
      Developmental Gene Expression 3
      Phenotypes 3
    • Earliest
      J:155956 Feng W, et al., Spatial and temporal analysis of gene expression during growth and fusion of the mouse facial prominences. PLoS One. 2009;4(12):e8066
    • Latest
      J:278239 Han X, et al., The lncRNA Hand2os1/Uph locus orchestrates heart development through regulation of precise expression of Hand2. Development. 2019 Jul 4;146(13)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    09/10/2019
    MGI 6.14
    The Jackson Laboratory