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Adamts6
Gene Detail
Symbol

Name
ID
Adamts6
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6
MGI:1347348
Synonyms
A930019D11Rik, ADAM-TS6, b2b1879.1Clo, b2b2029Clo, b2b2182Clo, b2b2187.1Clo, b2b2228Clo
Feature Type
protein coding gene
Genetic Map
Chromosome 13
56.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr13:104287873-104494763 bp, + strand
From Ensembl annotation of GRCm38

  206891 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:82573  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ADAMTS6
Gene Tree: Adamts6

Human
homologs
ADAMTS6, ADAM metallopeptidase with thrombospondin type 1 motif, 6
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 11174
neXtProt AC: NX_Q9UKP5

Human Synonyms: ADAM-TS6, ADAM-TS 6, ADAMTS-6

Human Chr (Location): 5q12; chr5:65148736-65482027 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Chemically induced (ENU)(8) Targeted(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for induced mutations exhibit cardiovascular defects including double outlet right ventricle, ventricular septal defects and biventricular hypertrophy, and hydrops, thymus hypoplasia short snout and cleft palate.
 
Phenotype Images(136)
Interactions
Adamts6 interacts with 295 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (3 annotations)
Process biological_process
Component cellular_component
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (1)    Tissues (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 1
cDNA source data(30)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase adamts6    NEW 
Molecular
reagents
All nucleic(32) cDNA(30) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000046169 (Evidence)
Entrez Gene 108154 (Evidence)
UniGene 208125
DFCI TC1719352, TC1590642, TC1608843, TC1614488, TC1602744, TC1591523
DoTS DT.91304843, DT.55214669, DT.110977271, DT.97354507, DT.94283509
NIA Mouse Gene Index U015212
Consensus CDS Project CCDS36773.1
International Mouse Phenotyping Consortium Status Adamts6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000046169 Ensembl Gene Model | MGI Sequence Detail 206891 C57BL/6J ±  kb
transcript ENSMUST00000065766 Ensembl | MGI Sequence Detail 4822 Not Applicable 
polypeptide ENSMUSP00000064570 Ensembl | MGI Sequence Detail 1117 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(22) UniProt(2)
Polymorphisms
SNPs within 2kb(1538 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010294 ADAM-TS Spacer 1
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR001590 Peptidase M12B, ADAM/reprolysin
InterPro IPR013273 Peptidase M12B, ADAM-TS
InterPro IPR002870 Peptidase M12B, propeptide
InterPro IPR010909 PLAC
InterPro IPR000884 Thrombospondin, type 1 repeat
Protein Ontology PR:000032252 a disintegrin and metalloproteinase with thrombospondin motifs 6
References
(Earliest) J:57247 Hurskainen TL, et al., ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family. J Biol Chem. 1999 Sep 3;274(36):25555-63
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(23)
Other
accession IDs
MGI:2444985, MGI:5476177, MGI:5487285, MGI:5491167, MGI:5491169, MGI:5547739

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory