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Adamts6
Gene Detail
 Symbol
Name
ID
Adamts6
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6
MGI:1347348
Synonyms A930019D11Rik, ADAM-TS6, b2b1879.1Clo, b2b2029Clo, b2b2182Clo, b2b2187.1Clo, b2b2228Clo
Feature Type protein coding gene
Genetic Map
Chromosome 13
56.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr13:104287873-104494763 bp, + strand
From NCBI annotation of GRCm38

  206891 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:82573  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Adamts6

Human
homologs
Human Homolog ADAMTS6, ADAM metallopeptidase with thrombospondin type 1 motif, 6
NCBI Gene ID 11174
neXtProt AC  NX_Q9UKP5
Human Synonyms  ADAM-TS6, ADAM-TS 6, ADAMTS-6
Human Chr (Location)  5q12; chr5:65148736-65481877 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Chemically induced (ENU)(8) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for induced mutations exhibit cardiovascular defects including double outlet right ventricle, ventricular septal defects and biventricular hypertrophy, and hydrops, thymus hypoplasia short snout and cleft palate.
 
Phenotype Images(136)
Interactions
Adamts6 interacts with 296 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (3 annotations)
Process biological_process
Component cellular_component
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (1)    Tissues (1)   
Theiler Stages: 11
Assay TypeResults
RT-PCR 1
cDNA source data(29)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(31) cDNA(29) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000046169 (Evidence)
Entrez Gene108154 (Evidence)
UniGene208125
DFCITC1590642, TC1591523, TC1602744, TC1608843, TC1614488
DoTSDT.110977271, DT.55214669, DT.94283509, DT.97354507
NIA Mouse Gene IndexU015212
Consensus CDS ProjectCCDS36773.1
International Mouse Knockout Project StatusAdamts6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 108154 NCBI Gene Model | MGI Sequence Detail 206891 C57BL/6J ±  kb
transcript NM_001081020 RefSeq | MGI Sequence Detail 4822 Not Specified 
polypeptide NP_001074489 RefSeq | MGI Sequence Detail 1117 Not Specified 

For the selected sequences
All sequences(32) RefSeq(8) UniProt(2)
Polymorphisms SNPs within 2kb(1538 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010294 ADAM-TS Spacer 1
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR001590 Peptidase M12B, ADAM/reprolysin
InterPro IPR013273 Peptidase M12B, ADAM-TS
InterPro IPR002870 Peptidase M12B, propeptide
InterPro IPR010909 PLAC
InterPro IPR000884 Thrombospondin, type 1 repeat
Protein Ontology PR:000032252 A disintegrin and metalloproteinase with thrombospondin motifs 6
References (Earliest) J:57247 Hurskainen TL, et al., ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family. J Biol Chem. 1999 Sep 3;274(36):25555-63
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(24)
Other
accession IDs
MGI:2444985, MGI:5476177, MGI:5487285, MGI:5491167, MGI:5491169, MGI:5547739

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory