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Plxnd1
Gene Detail
Symbol

Name
ID
Plxnd1
plexin D1
MGI:2154244
Synonyms
6230425C21Rik, b2b1863Clo, b2b553Clo
Feature Type
protein coding gene
Genetic Map
Chromosome 6
53.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr6:115954811-115995005 bp, - strand
From VEGA annotation of GRCm38

  40195 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22866  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PLXND1
Gene Tree: Plxnd1

Human
homologs
PLXND1, plexin D1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 23129
neXtProt AC: NX_Q9Y4D7

Human Synonyms: PLEXD1

Human Chr (Location): 3q22.1; chr3:129555213-129606739 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Chemically induced (ENU)(2) Spontaneous(1) Targeted(7)
Genomic Mutations involving Plxnd1 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice display neonatal lethality, thin-walled atria, and vascular abnormalities including abnormal branchial arch artery development, cardiac outflow tract abnormalities, and reduced vascular smooth muscle around some vessels.
 
Human Diseases Modeled in Mice Using Plxnd1 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(32)
Interactions
Plxnd1 interacts with 203 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (28 records)
Data Summary: Results (66)    Tissues (40)    Images (36)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 58
Northern blot 8
cDNA source data(94)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA PLXND1 ; Xenbase plxnd1 ; ZFIN plxnd1    NEW 
Molecular
reagents
All nucleic(96) cDNA(95) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000021239 (Evidence)
Ensembl Gene Model ENSMUSG00000030123 (Evidence)
Entrez Gene 67784 (Evidence)
UniGene 3085
DFCI TC1581885, TC1597035, TC1600030, TC1587092
DoTS DT.97360480, DT.531787, DT.110474064
Consensus CDS Project CCDS20448.1
International Mouse Phenotyping Consortium Status Plxnd1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021239 VEGA Gene Model | MGI Sequence Detail 40195 C57BL/6J ±  kb
transcript OTTMUST00000050306 VEGA | MGI Sequence Detail 6907 Not Applicable 
polypeptide OTTMUSP00000023467 VEGA | MGI Sequence Detail 1925 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(3) UniProt(6)
Polymorphisms
SNPs within 2kb(283 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002909 Cell surface receptor IPT/TIG
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR002165 Plexin
InterPro IPR013548 Plexin, cytoplasmic RasGAP domain
InterPro IPR016201 Plexin-like fold
InterPro IPR008936 Rho GTPase activation protein
InterPro IPR001627 Semaphorin/CD100 antigen
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000012899 plexin-D1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:220818 Minchin JE, et al., Plexin D1 determines body fat distribution by regulating the type V collagen microenvironment in visceral adipose tissue. Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4363-8
All references(72)
Disease annotation references (1)
Other
accession IDs
MGI:1915034, MGI:5316760, MGI:5476162

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory