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Plxnd1
Gene Detail
 Symbol
Name
ID
Plxnd1
plexin D1
MGI:2154244
Synonyms 6230425C21Rik, b2b1863Clo, b2b553Clo
Feature Type protein coding gene
Genetic Map
Chromosome 6
53.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr6:115954811-115995005 bp, - strand
From VEGA annotation of GRCm38

  40195 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22866  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Plxnd1

Human
homologs
Human Homolog PLXND1, plexin D1
NCBI Gene ID 23129
neXtProt AC  NX_Q9Y4D7
Human Synonyms  PLEXD1
Human Chr (Location)  3q22.1; chr3:129555213-129606739 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Chemically induced (ENU)(2) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display neonatal lethality, thin-walled atria, and vascular abnormalities including abnormal branchial arch artery development, cardiac outflow tract abnormalities, and reduced vascular smooth muscle around some vessels.
 
Human Diseases Modeled Using Mouse Plxnd1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(32)
Interactions
Plxnd1 interacts with 203 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process angiogenesis, dichotomous subdivision of terminal units involved in salivary gland branching, ...
Component integral component of membrane, integral component of plasma membrane, ...
Function protein binding, protein domain specific binding, ...
External Resources: FuncBase
Expression
Literature Summary: (26 records)
Data Summary: Results (66)    Tissues (40)    Images (36)
Theiler Stages: 15, 17, 20, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 58
Northern blot 8
cDNA source data(94)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(96) cDNA(95) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021239 (Evidence)
Ensembl Gene ModelENSMUSG00000030123 (Evidence)
Entrez Gene67784 (Evidence)
UniGene3085
DFCITC1581885, TC1587092, TC1597035, TC1600030
DoTSDT.110474064, DT.531787, DT.97360480
Consensus CDS ProjectCCDS20448.1
International Mouse Knockout Project StatusPlxnd1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021239 VEGA Gene Model | MGI Sequence Detail 40195 C57BL/6J ±  kb
transcript OTTMUST00000050306 VEGA | MGI Sequence Detail 6907 Not Applicable 
polypeptide OTTMUSP00000023467 VEGA | MGI Sequence Detail 1925 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(2) UniProt(6)
Polymorphisms SNPs within 2kb(283 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002909 Cell surface receptor IPT/TIG
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR002165 Plexin
InterPro IPR013548 Plexin, cytoplasmic RasGAP domain
InterPro IPR016201 Plexin-like fold
InterPro IPR008936 Rho GTPase activation protein
InterPro IPR001627 Semaphorin/CD100 antigen
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000012899 plexin-D1
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:206656 Worzfeld T, et al., Genetic dissection of plexin signaling in vivo. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2194-9
All references(70)
Disease annotation references (1)
Other
accession IDs
MGI:1915034, MGI:5316760, MGI:5476162

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory