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Armc4
Gene Detail
Symbol

Name
ID
Armc4
armadillo repeat containing 4
MGI:1922184
Synonyms
4930463I21Rik, b2b227.1Clo, b2b643Clo
Feature Type
protein coding gene
Genetic Map
Chromosome 18
4.53 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr18:7088233-7297901 bp, - strand
From Ensembl annotation of GRCm38

  209669 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9992  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 2 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ARMC4
Gene Tree: Armc4

Human
homologs
ARMC4, armadillo repeat containing 4
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 55130
neXtProt AC: NX_Q5T2S8

Human Synonyms: CILD23

Human Chr (Location): 10p12.1; chr10:27812164-27999067 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ARMC4

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Chemically induced (ENU)(2) Gene trapped(2) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for ENU-induced mutations exhibit situs inversus totalis or heterotaxia with congenital heart disease including double outlet right ventricle and ventricular septal defects. Dyskinetic, slow, or immotile airway cilia are also observed.
 
Human Diseases Modeled in Mice Using Armc4 (1)    Mutations Annotated to Human Diseases (2)    Phenotype Images(36)
Interactions
Armc4 interacts with 92 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process cell projection organization, cilium movement, ...
Component axoneme, cell projection, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (3)    Tissues (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 3
cDNA source data(2)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase armc4    NEW 
Molecular
reagents
All nucleic(3) cDNA(3)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000061802 (Evidence)
Entrez Gene 74934 (Evidence)
DFCI TC1675043, TC1602316
DoTS DT.87041734, DT.60108267
NIA Mouse Gene Index U079256
Consensus CDS Project CCDS37729.1
International Mouse Phenotyping Consortium Status Armc4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000061802 Ensembl Gene Model | MGI Sequence Detail 209669 C57BL/6J ±  kb
transcript ENSMUST00000081275 Ensembl | MGI Sequence Detail 3477 Not Applicable 
polypeptide ENSMUSP00000080028 Ensembl | MGI Sequence Detail 1037 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(14) UniProt(1)
Polymorphisms
SNPs within 2kb(811 from dbSNP Build 137)    SNPs within 2kb including multiple locations(819)
Protein-related
information
ResourceIDDescription
InterPro IPR000225 Armadillo
InterPro IPR011989 Armadillo-like helical
InterPro IPR026959 Armadillo repeat-containing protein 4
InterPro IPR016024 Armadillo-type fold
Protein Ontology PR:000030558 armadillo repeat-containing protein 4
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:206685 Hjeij R, et al., ARMC4 mutations cause primary ciliary dyskinesia with randomization of left/right body asymmetry. Am J Hum Genet. 2013 Aug 8;93(2):357-67
All references(26)
Disease annotation references (2)
Other
accession IDs
MGI:5311339, MGI:5437094

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory