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Armc4
Gene Detail
 Symbol
Name
ID
Armc4
armadillo repeat containing 4
MGI:1922184
Synonyms 4930463I21Rik, b2b227.1Clo, b2b643Clo
Feature Type protein coding gene
Genetic Map
Chromosome 18
4.53 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr18:7088233-7297901 bp, - strand
From NCBI annotation of GRCm38

  209669 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9992  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 2 dog; 1 chicken; 1 zebrafish

Gene Tree: Armc4

Human
homologs
Human Homolog ARMC4, armadillo repeat containing 4
NCBI Gene ID 55130
neXtProt AC  NX_Q5T2S8
Human Synonyms  CILD23
Human Chr (Location)  10p12.1-p11.23; chr10:27812166-27999048 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human ARMC4
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Chemically induced (ENU)(2) Gene trapped(2) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for ENU-induced mutations exhibit situs inversus totalis or heterotaxia with congenital heart disease including double outlet right ventricle and ventricular septal defects. Dyskinetic, slow, or immotile airway cilia are also observed.
 
Human Diseases Modeled Using Mouse Armc4 (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(36)
Interactions
Armc4 interacts with 93 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cell projection organization, cilium movement, ...
Component axoneme, cell projection, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(2)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(2) cDNA(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000061802 (Evidence)
Entrez Gene74934 (Evidence)
DFCITC1602316, TC1675043
DoTSDT.60108267, DT.87041734
NIA Mouse Gene IndexU079256
Consensus CDS ProjectCCDS37729.1
International Mouse Knockout Project StatusArmc4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 74934 NCBI Gene Model | MGI Sequence Detail 209669 C57BL/6J ±  kb
transcript NM_001081393 RefSeq | MGI Sequence Detail 3477 Not Specified 
polypeptide B2RY50 UniProt | EBI | MGI Sequence Detail 1037 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(8) UniProt(1)
Polymorphisms SNPs within 2kb(811 from dbSNP Build 137)    SNPs within 2kb including multiple locations(819)
Protein-related
information
ResourceIDDescription
InterPro IPR000225 Armadillo
InterPro IPR011989 Armadillo-like helical
InterPro IPR026959 Armadillo repeat-containing protein 4
InterPro IPR016024 Armadillo-type fold
Protein Ontology PR:000030558 armadillo repeat-containing protein 4
Graphical View of Protein Domain Structure
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:206685 Hjeij R, et al., ARMC4 mutations cause primary ciliary dyskinesia with randomization of left/right body asymmetry. Am J Hum Genet. 2013 Aug 8;93(2):357-67
All references(27)
Disease annotation references (2)
Other
accession IDs
MGI:5311339, MGI:5437094

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory