Ap1b1
Gene Detail

Symbol Name ID

Ap1b1 adaptor protein complex AP-1, beta 1 subunit MGI:1096368

Synonyms

Adtb1, b2b1660Clo, beta-prime adaptin

Feature Type

protein coding gene

Genetic Map

Chromosome 11

3.15 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr11:4986824-5042729 bp, + strand From VEGA annotation of GRCm38   55906 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21972  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: adaptor protein complex, beta subunit
Gene Tree: Ap1b1

Human homologs

Human Homolog		AP1B1, adaptor-related protein complex 1, beta 1 subunit
NCBI Gene ID		162
neXtProt AC		NX_Q10567
Human Synonyms		ADTB1, AP105A, BAM22, CLAPB2
Human Chr (Location)		22q12.2; chr22:29723669-29784572 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(20) : Targeted(4) Gene trapped(15) Chemically induced(1)
 

Mice homozygous for an ENU-induced mutation exhibit heterotaxy and situs inversus totalis with left pulmonary isomerism, hypoplastic spleen/asplenia, abnormal bilateral inferior vena cava (IVC) malaligned sternovertebrae, and dyskinetic/immotile respiratory cilia.

 
Human Diseases Modeled Using Mouse Ap1b1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(20)

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	clathrin coat assembly, endocytosis, ...
Component	clathrin adaptor complex, cytoplasmic vesicle, ...
Function	protein binding, protein transporter activity

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (2)    Tissues (2)   
Theiler Stages: 21

Assay Type	Results
RNA in situ	2

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(20) Genomic(5) cDNA(14) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000005076 (Evidence)
Ensembl Gene Model	ENSMUSG00000009090 (Evidence)
Entrez Gene	11764 (Evidence)
DFCI	TC1573306, TC1586761, TC1673431
NIA Mouse Gene Index	U012278
Consensus CDS Project	CCDS36100.1
International Mouse Knockout Project Status	Ap1b1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005076	VEGA Gene Model | MGI Sequence Detail	55906	C57BL/6J
transcript	OTTMUST00000011327	VEGA | MGI Sequence Detail	3735	Not Applicable
polypeptide	OTTMUSP00000005282	VEGA | MGI Sequence Detail	923	Not Applicable

All sequences(68) RefSeq(6) UniProt(7)

Polymorphisms

SNPs(246 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016342	AP-1, 2,4 complex subunit beta
InterPro	IPR026739	AP complex subunit beta
InterPro	IPR011989	Armadillo-like helical
InterPro	IPR016024	Armadillo-type fold
InterPro	IPR012295	Beta2-adaptin/TBP, C-terminal domain
InterPro	IPR015151	Beta-adaptin appendage, C-terminal subdomain
InterPro	IPR008152	Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
InterPro	IPR013037	Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain
InterPro	IPR002553	Clathrin/coatomer adaptor, adaptin-like, N-terminal
InterPro	IPR009028	Coatomer/calthrin adaptor appendage, C-terminal subdomain
InterPro	IPR013041	Coatomer/clathrin adaptor appendage, Ig-like subdomain
Protein Ontology	PR:000004090	AP-1 complex subunit beta-1

References

(Earliest) J:42384 Guilbaud C, et al., Characterization of the mouse beta-prime adaptin gene; cDNA sequence, genomic structure, and chromosomal localization. Mamm Genome. 1997 Sep;8(9):651-6
(Latest) J:177015 Kang RS, et al., ARH cooperates with AP-1B in the exocytosis of LDLR in polarized epithelial cells. J Cell Biol. 2011 Apr 4;193(1):51-60
All references(47)

Other accession IDs

MGI:5433318