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Daw1 Gene Detail
Summary
  • Symbol
    Daw1
  • Name
    dynein assembly factor with WDR repeat domains 1
  • Synonyms
    4930563E19Rik, 4933429D11Rik, b2b1116Clo, b2b1584Clo, Wdr69
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923089
    NCBI Gene: 71227
Location & Maps
more
  • Sequence Map
    Chr1:83159752-83210574 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      50823 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 42.70 cM, cytoband C5
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    DAW1, dynein assembly factor with WD repeats 1
  • Human Ortholog
    DAW1, dynein assembly factor with WD repeats 1
    Orthology source: HGNC
  • Synonyms
    ODA16, WDR69
  • Links
    NCBI Gene ID: 164781
    neXtProt AC: NX_Q8N136

  • Chr Location
    2q36.3; chr2:227871054-227924347 (+)  GRCh38.p2

  • HCOP
    human homology predictions: DAW1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 2 alleles in 2 genetic backgrounds
    41 images
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (ENU)
    2
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Genomic Mutations
    2 involving Daw1
  • Incidental Mutations
    APF , CvDC
Mice homozygous for an induced mutation exhibit dextrocardia associated with situs inversus totalis, overriding aorta, ventricular septal defects, and dual inferior vena cava as well as dextrogastria, hypoplastic spleen, inverted liver, lung lobation/isomerism and dyskinetic/immotile airway cilia
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022978 VEGA Gene Model | MGI Sequence Detail 50823 C57BL/6J ±  kb
transcript OTTMUST00000064965 VEGA | MGI Sequence Detail 1651 Not Applicable  
polypeptide OTTMUSP00000032315 VEGA | MGI Sequence Detail 415 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    287 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    cDNA 7

    Microarray probesets 2
Other
Accession IDs
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MGI:1918477, MGI:5311348, MGI:5431490
References
more
  • Summaries
    All 18
    Gene Ontology 1
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:222159 Li Y, et al., Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Nature. 2015 May 28;521(7553):520-4

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory