Mirc27 MGI Mouse Complex/Cluster/Region Detail - MGI:5315433 - microRNA cluster 27, including Mir497 through Mir195a

Mirc27 Complex/Cluster/Region Detail

Symbol

Mirc27
Name

microRNA cluster 27, including Mir497 through Mir195a

Feature Type

complex/cluster/region
IDs

MGI:5315433
Cluster Members

Mir497, Mir195a (2 members)

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Sequence Map

Genome coordinates not available from the current reference assembly.

Genetic Map

Chromosome 11, Syntenic

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
7 phenotype references

All Mutations and Alleles

5
Endonuclease-mediated

2
Targeted

3
Find Mice (IMSR)

3 strains or lines available

Mice mice homozygous for a conditional allele activated in hematopoietic cells exhibit normal blood and spleen CD5+ B cell numbers, spleen weight, NK cell development, early B-cell development, and immune cell homeostasis and function.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

5
Tissues

3
Literature Summary

1

Images

Tissue x Stage Matrix

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All nucleic 1

Primer pair 1

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miRBase

MI0000237, MI0004636

Summaries

All 9

Developmental Gene Expression 1

Phenotypes 7
Earliest

J:105741 Griffiths-Jones S, et al., miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4
Latest

J:330835 Hutter K, et al., The miR-15a/16-1 and miR-15b/16-2 clusters regulate early B cell development by limiting IL-7 receptor expression. Front Immunol. 2022;13:967914

Mirc27 Cluster contains:

More Data for these features

Member	Feature Type	Location
Mir497, microRNA 497	miRNA gene	Chr11:70125543-70125626 (+)
Mir195a, microRNA 195a	miRNA gene	Chr11:70125868-70125961 (+)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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