Nme1nme2 Gene Detail

Summary

• Symbol
  Nme1nme2
• Name
  NME/NM23 nucleoside diphosphate kinase 1 and 2 readthrough
• Synonyms
  Gm20390

• Feature Type
  protein coding gene
• IDs
  MGI:5141855
• Alliance
  gene page
• Transcription Start Sites
  5 TSS

Location &
Maps

• Sequence Map
  Chr11:93840645-93859119 bp, - strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 11, 58.88 cM

Strain
Comparison

• SNPs within 2kb
  289 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_5141855	protein coding gene	Chr11:93840645-93859119 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018947	protein coding gene	Chr11:95977930-96001030 (-)
A/J	MGP_AJ_G0018915	protein coding gene	Chr11:92180370-92198650 (-)
AKR/J	MGP_AKRJ_G0018885	protein coding gene	Chr11:95053517-95072200 (-)
BALB/cJ	MGP_BALBcJ_G0018888	protein coding gene	Chr11:92606695-92625934 (-)
C3H/HeJ	MGP_C3HHeJ_G0018702	protein coding gene	Chr11:95125398-95143687 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019340	protein coding gene	Chr11:98975494-98995666 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016971	protein coding gene	Chr11:89670835-89689516 (-)
CAST/EiJ	MGP_CASTEiJ_G0018257	protein coding gene	Chr11:95812089-95830524 (-)
CBA/J	MGP_CBAJ_G0018673	protein coding gene	Chr11:103084661-103106291 (-)
DBA/2J	MGP_DBA2J_G0018781	protein coding gene	Chr11:91743617-91762464 (-)
FVB/NJ	MGP_FVBNJ_G0018770	protein coding gene	Chr11:91162019-91180405 (-)
LP/J	MGP_LPJ_G0018851	protein coding gene	Chr11:96536804-96563514 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018797	protein coding gene	Chr11:103137938-103160721 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019380	protein coding gene	Chr11:95237079-95260195 (-)
PWK/PhJ	MGP_PWKPhJ_G0018027	protein coding gene	Chr11:92663586-92683721 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017817	protein coding gene	Chr11:94927323-94948019 (-)
WSB/EiJ	MGP_WSBEiJ_G0018306	protein coding gene	Chr11:95122067-95142799 (-)

Homology

• Gene Tree
  Nme1nme2
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  9 phenotype references
  

• All Mutations and Alleles
  4
• Targeted
  4
• Genomic Mutations
  4 involving Nme1nme2
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  4 strains or lines available

Expression

• Assay Results
  706

Tissue x Stage Matrix

• Other Mouse Links
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  22
• UniProt
  1

• Ensembl
  ENSMUSG00000091228 (Evidence)

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000091228	Ensembl Gene Model | MGI Sequence Detail	18475	C57BL/6J
transcript	ENSMUST00000170303	Ensembl | MGI Sequence Detail	991	Not Applicable
polypeptide	ENSMUSP00000132590	Ensembl | MGI Sequence Detail	267	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• EC
  2.7.4.6
• InterPro Domains
  IPR001564 Nucleoside diphosphate kinase
  IPR023005 Nucleoside diphosphate kinase, active site
  IPR034907 Nucleoside diphosphate kinase-like domain
  IPR036850 Nucleoside diphosphate kinase-like domain superfamily

References

• Summaries
  All 13

  Diseases 1

  Phenotypes 9
• Earliest
  J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
• Latest
  J:316091 Leonard MK, et al., Comprehensive molecular profiling of UV-induced metastatic melanoma in Nme1/Nme2-deficient mice reveals novel markers of survival in human patients. Oncogene. 2021 Nov;40(45):6329-6342

TSS for Nme1nme2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr110122	Chr11:93859123-93859134 (-)	-10 bp
Tssr110121	Chr11:93859068-93859107 (-)	31 bp
Tssr110120	Chr11:93858849-93858879 (-)	255 bp
Tssr110119	Chr11:93856783-93856792 (-)	2,331 bp
Tssr110118	Chr11:93856758-93856782 (-)	2,349 bp