About   Help   FAQ
Anpep Gene Detail
Summary
  • Symbol
    Anpep
  • Name
    alanyl (membrane) aminopeptidase
  • Synonyms
    aminopeptidase N, Apn, Cd13
  • Feature Type
    protein coding gene
  • IDs
    MGI:5000466
    NCBI Gene: 16790
Location & Maps
more
  • Sequence Map
    Chr7:79821803-79861059 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      39257 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 45.19 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ANPEP, alanyl aminopeptidase, membrane
  • Vertebrate Orthologs
    15
  • Human Ortholog
    ANPEP, alanyl aminopeptidase, membrane
    Orthology source: HomoloGene
  • Synonyms
    APN, CD13, GP150, LAP1, P150, PEPN
  • Links
    NCBI Gene ID: 290
    neXtProt AC: NX_P15144

  • Chr Location
    15q25-q26; chr15:89784895-89814854 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 68163
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;6 zebrafish
  • HCOP
    human homology predictions: ANPEP
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 3 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    1
  • Gene trapped
    4
  • Radiation induced
    2
  • Targeted
    3
  • Transgenic
    3
  • Genomic Mutations
    3 involving Anpep
  • Incidental Mutations
Mice homozygous for different knock-out alleles exhibit an increase in CD4+ thymocytes, altered macrophage adhesion, pathological neovascularization and/or altered mammary gland morphology during gestation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022543 VEGA Gene Model | MGI Sequence Detail 39257 C57BL/6J ±  kb
transcript OTTMUST00000053999 VEGA | MGI Sequence Detail 3797 Not Applicable  
polypeptide OTTMUSP00000025718 VEGA | MGI Sequence Detail 966 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    192 from dbSNP Build 142
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000002031 aminopeptidase N
  • EC
  • InterPro Domains
    IPR024571 ERAP1-like C-terminal domain
    IPR001930 Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
    IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal
Molecular
Reagents
less
  • All nucleic 119
    cDNA 117
    Primer pair 1
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 50
    Developmental Gene Expression 11
    Gene Ontology 6
    Phenotypes 25
  • Earliest
    J:18385 Look AT, et al., Human myeloid plasma membrane glycoprotein CD13 (gp150) is identical to aminopeptidase N. J Clin Invest. 1989 Apr;83(4):1299-307
  • Latest
    J:218576 Ghosh M, et al., Molecular mechanisms regulating CD13-mediated adhesion. Immunology. 2014 Aug;142(4):636-47

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/19/2016
MGI 6.04
The Jackson Laboratory