About   Help   FAQ
Dthd1 Gene Detail
Summary
  • Symbol
    Dthd1
  • Name
    death domain containing 1
  • Synonyms
    Gm17384
Location &
Maps
more
  • Sequence Map
    Chr5:62969017-63045651 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 32.04 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2363 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_4937018
 protein coding gene Chr5:62968999-63045661 (+)
129S1/SvImJ ENSMUSG00200000041
 protein coding gene Chr5:58581974-58658617 (+)
A/J ENSMUSG00195000276
 protein coding gene Chr5:57936376-58014912 (+)
AKR/J ENSMUSG00220006966
 protein coding gene Chr5:58064143-58142685 (+)
BALB/cJ ENSMUSG00180006068
 protein coding gene Chr5:57699108-57777950 (+)
C3H/HeJ ENSMUSG00175001714
 protein coding gene Chr5:59734638-59813222 (+)
C57BL/6NJ ENSMUSG00215002755
 protein coding gene Chr5:58513637-58590291 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027232
 protein coding gene Chr5:56201628-56270871 (+)
CAST/EiJ ENSTCUG00005000283
 protein coding gene Chr5:57656216-57733149 (+)
CBA/J ENSMUSG00210000066
 protein coding gene Chr5:58661867-58740404 (+)
DBA/2J ENSMUSG00185005565
 protein coding gene Chr5:60515815-60594400 (+)
FVB/NJ ENSMUSG00205009620
 protein coding gene Chr5:57472000-57550686 (+)
JF1/MsJ ENSUMUG00000010037
 protein coding gene Chr5:65039218-65119715 (+)
LP/J ENSMUSG00230005728
 protein coding gene Chr5:65197836-65274476 (+)
NOD/ShiLtJ ENSMUSG00190000205
 protein coding gene Chr5:57629347-57707924 (+)
NZO/HlLtJ ENSMUSG00225002439
 protein coding gene Chr5:70319851-70396485 (+)
PWK/PhJ ENSLUMG00010003986
 protein coding gene Chr5:57667501-57746873 (+)
SPRET/EiJ ENSMSPG00010003931
 protein coding gene Chr5:59437476-59514111 (+)
WSB/EiJ ENSIUOG00005000059
 protein coding gene Chr5:60596169-60680904 (+)



Homology
more
  • Human Ortholog
    DTHD1, death domain containing 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DTHD1, death domain containing 1
  • Links
    NCBI Gene ID: 401124
    UniProt: Q6ZMT9

  • Chr Location
    4p14; chr4:36281616-36347511 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    1
  • GO References
    1
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000090326 Ensembl Gene Model | MGI Sequence Detail 76635 C57BL/6J ±  kb
transcript ENSMUST00000238474 Ensembl | MGI Sequence Detail 2877 Not Applicable  
polypeptide ENSMUSP00000158635 Ensembl | MGI Sequence Detail 905 Not Applicable  
For the selected sequence
Protein
Information
less
References
more
  • Summaries
    All 32
    Gene Ontology 1
    Phenotypes 23
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory