Sprr2a2 Gene Detail

Summary

• Symbol
  Sprr2a2
• Name
  small proline-rich protein 2A2

• Feature Type
  protein coding gene
• IDs
  MGI:3845026
  NCBI Gene: 100303744
• Alliance
  genome feature page

Location &
Maps

• Sequence Map
  Chr3:92157982-92164610 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 3, 40.14 cM

Strain
Comparison

• SNPs within 2kb
  1 from dbSNP Build 142
• Strain Annotations
  3

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3845026	protein coding gene	Chr3:92123227-92164610 (+)
129S1/SvImJ	no annotation
A/J	no annotation
AKR/J	ENSMUSG00220045417	protein coding gene	Chr3:88211159-88217272 (+)
BALB/cJ	no annotation
C3H/HeJ	no annotation
C57BL/6NJ	no annotation
CAROLI/EiJ	no annotation
CAST/EiJ	no annotation
CBA/J	no annotation
DBA/2J	no annotation
FVB/NJ	no annotation
JF1/MsJ	no annotation
LP/J	no annotation
NOD/ShiLtJ	ENSMUSG00190032295	protein coding gene	Chr3:89374692-89380804 (+)
NZO/HlLtJ	no annotation
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	no annotation

Homology

• Gene Tree
  Sprr2a2
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  6 phenotype references
  

• All Mutations and Alleles
  3
• Chemically induced (other)
  1
• Endonuclease-mediated
  1
• Radiation induced
  1
• Genomic Mutations
  3 involving Sprr2a2
• Find Mice (IMSR)
  0 strains or lines available

Expression

• Assay Results
  605
• Tissues
  2
• cDNA Data
  7
• Literature Summary
  1

Images

Tissue x Stage Matrix

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  20
• RefSeq
  2
• CCDS
  CCDS50975.1

• Ensembl
  ENSMUSG00000068893 (Evidence)
• NCBI Gene
  100303744

Representative Sequences			Length	Strain/Species
genomic	100303744	NCBI Gene Model | MGI Sequence Detail	6629	C57BL/6J
transcript	NM_001164787	RefSeq | MGI Sequence Detail	3518	C57BL/6
polypeptide	NP_001158259	RefSeq | MGI Sequence Detail	83	C57BL/6

Molecular
Reagents

• All nucleic 8

  cDNA 8

References

• Summaries
  All 16

  Developmental Gene Expression 1

  Diseases 1

  Phenotypes 6
• Earliest
  J:52302 Song HJ, et al., Mouse Sprr2 genes: a clustered family of genes showing differential expression in epithelial tissues. Genomics. 1999 Jan 1;55(1):28-42
• Latest
  J:325777 Zhang C, et al., Small proline-rich proteins (SPRRs) are epidermally produced antimicrobial proteins that defend the cutaneous barrier by direct bacterial membrane disruption. Elife. 2022 Mar 2;11:e76729