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Hotair Gene Detail
Summary
  • Symbol
    Hotair
  • Name
    HOX transcript antisense RNA (non-protein coding)
Location & Maps
more
  • Sequence Map
    Chr15:102944062-102947730 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3669 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 58.01 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    HOTAIR, HOX transcript antisense RNA
  • Human Ortholog
    HOTAIR, HOX transcript antisense RNA
    Orthology source: HGNC
  • Synonyms
    HOXAS, HOXC11-AS1, HOXC-AS4, NCRNA00072
  • Links
    NCBI Gene ID: 100124700

  • Chr Location
    12q13.13; chr12:53962308-53974956 (-)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 3 alleles in 2 genetic backgrounds
    1 images
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene results in caudal vertebral transformation. Additional phenotypes may include lumbar vertebral transformation and structural malformations of the metacarpal-carpal bones, tail and hind limbs.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    • All Sequences
    • RefSeq
    • UniGene
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000032781 VEGA Gene Model | MGI Sequence Detail 3669 C57BL/6J ±  kb
    transcript OTTMUST00000081627 VEGA | MGI Sequence Detail 2006 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      21 from dbSNP Build 142
    Molecular
    Reagents
    less
    • All nucleic 5
      Genomic 1
      cDNA 2
      Primer pair 2
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 3
      Phenotypes 24
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:239002 Yang L, et al., Long non-coding RNA HOTAIR promotes ischemic infarct induced by hypoxia through up-regulating the expression of NOX2. Biochem Biophys Res Commun. 2016 Oct 14;479(2):186-191

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory