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Mrgpra2a Gene Detail
Summary
  • Symbol
    Mrgpra2a
  • Name
    MAS-related GPR, member A2A
  • Feature Type
    protein coding gene
  • IDs
    MGI:3821888
    NCBI Gene: 668727
  • Gene Overview
    MyGene.info: MRGPRX3
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr7:47426328-47452139 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 30.84 cM
Strain
Comparison
more
  • SNPs within 2kb
    17 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3821888
protein coding gene Chr7:47426325-47452204 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032284
protein coding gene Chr7:47906682-47928126 (-)
A/J MGP_AJ_G0032263
protein coding gene Chr7:46829910-47076940 (-)
AKR/J MGP_AKRJ_G0032199
protein coding gene Chr7:48101501-48102672 (-)
BALB/cJ MGP_BALBcJ_G0032275
protein coding gene Chr7:46761769-46941755 (-)
C3H/HeJ MGP_C3HHeJ_G0031988
protein coding gene Chr7:48554807-48555978 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032766
protein coding gene Chr7:50219799-50222183 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0031316
protein coding gene Chr7:40044374-40174993 (-)
CBA/J MGP_CBAJ_G0031953
protein coding gene Chr7:51689506-51690677 (-)
DBA/2J MGP_DBA2J_G0032110
protein coding gene Chr7:46413279-46414450 (-)
FVB/NJ MGP_FVBNJ_G0032064
protein coding gene Chr7:46389829-46415668 (-)
LP/J MGP_LPJ_G0032191
protein coding gene Chr7:48581963-48611311 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032101
protein coding gene Chr7:50601924-50626274 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032783
protein coding gene Chr7:47500816-47536187 (-)
PWK/PhJ MGP_PWKPhJ_G0021529
protein coding gene Chr16:9716479-9717650 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030878
protein coding gene Chr7:35325202-35347084 (-)
WSB/EiJ MGP_WSBEiJ_G0031436
protein coding gene Chr7:47791360-47979517 (-)



Homology
more
  • Human Ortholog
    MRGPRX3, MAS related GPR family member X3
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MRGPRX3, MAS related GPR family member X3
    Orthology source: HomoloGene
  • Synonyms
    GPCR, MRGX3, SNSR1, SNSR2
  • Links
    NCBI Gene ID: 117195
    neXtProt AC: NX_Q96LB0
    UniProt: Q96LB0

  • Chr Location
    11p15.1; chr11:18120955-18138480 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000093973 Ensembl Gene Model | MGI Sequence Detail 25812 C57BL/6J ±  kb
transcript ENSMUST00000159004 Ensembl | MGI Sequence Detail 1240 Not Applicable  
polypeptide ENSMUSP00000124631 Ensembl | MGI Sequence Detail 331 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
Molecular
Reagents
less
  • All nucleic 1
    cDNA 1

    Microarray probesets 1
References
more
  • Summaries
    All 21
    Gene Ontology 1
    Phenotypes 10
  • Earliest
    J:157470 Liu Q, et al., Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus. Cell. 2009 Dec 24;139(7):1353-65
  • Latest
    J:283004 Jurcakova D, et al., Allergen-induced histaminergic and non-histaminergic activation of itch C-fiber nerve terminals in mouse skin. Neuroscience. 2019 Jul 1;410:55-58

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory