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Sco2
Gene Detail
Symbol

Name
ID
Sco2
SCO cytochrome oxidase deficient homolog 2 (yeast)
MGI:3818630
Feature Type
protein coding gene
Genetic Map
Chromosome 15
44.85 cM
Detailed Genetic Map ± 1 cM

Sequence Map
Chr15:89371639-89373818 bp, - strand
From Ensembl annotation of GRCm38

  2180 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68444  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: SCO1 protein
Gene Tree: Sco2

Human
homologs
Human Homolog SCO2, SCO2 cytochrome c oxidase assembly protein
NCBI Gene ID 9997
neXtProt AC  NX_O43819
Human Synonyms  CEMCOX1, MYP6, SCO1L
Human Chr (Location)  22q13.33; chr22:50523568-50526439 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human SCO2
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Radiation induced(1) Targeted(2)
Genomic Mutations involving Sco2 (1)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit embryonic lethality. Mice heterozygous for a knock-out allele and a knock-in allele exhibit muscle weakness and reduced exercise endurance.
 
Human Diseases Modeled Using Mouse Sco2 (1)    Alleles Annotated to Human Diseases(2)   
Interactions
Sco2 interacts with 19 markers (Mir34a, Mir34b, Mir34c, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (111)    Tissues (107)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 7
RNA in situ 94
Northern blot 10
cDNA source data(3)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(4) cDNA(4)
Microarray probesets(1)
Other database
links
Ensembl Gene ModelENSMUSG00000091780 (Evidence)
Entrez Gene100126824 (Evidence)
Consensus CDS ProjectCCDS49701.1
International Mouse Knockout Project StatusSco2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000091780 Ensembl Gene Model | MGI Sequence Detail 2180 C57BL/6J ±  kb
transcript ENSMUST00000167643 Ensembl | MGI Sequence Detail 1143 Not Applicable 
polypeptide ENSMUSP00000131943 Ensembl | MGI Sequence Detail 255 Not Applicable 

For the selected sequences
All sequences(14) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(11 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003782 Copper chaperone SCO1/SenC
InterPro IPR017276 Synthesis of cytochrome c oxidase, Sco1/Sco2
InterPro IPR012336 Thioredoxin-like fold
Protein Ontology PR:000014532 protein SCO2, mitochondrial
References
(Earliest) J:122989 Visel A, et al., GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
(Latest) J:176080 Viscomi C, et al., In vivo correction of COX deficiency by activation of the AMPK/PGC-1alpha axis. Cell Metab. 2011 Jul 6;14(1):80-90
All references(18)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory