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Sco2
Gene Detail
 Symbol
Name
ID
Sco2
SCO cytochrome oxidase deficient homolog 2 (yeast)
MGI:3818630
Feature Type protein coding gene
Genetic Map
Chromosome 15
44.85 cM
Detailed Genetic Map ± 1 cM

Sequence Map
Chr15:89371639-89373818 bp, - strand
From Ensembl annotation of GRCm38

  2180 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68444  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: SCO1 protein
Gene Tree: Sco2

Human
homologs
Human Homolog SCO2, SCO2 cytochrome c oxidase assembly protein
NCBI Gene ID 9997
neXtProt AC  NX_O43819
Human Synonyms  CEMCOX1, MYP6, SCO1L
Human Chr (Location)  22q13.33; chr22:50523568-50526439 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human SCO2
Alleles
and
phenotypes
All alleles(2) : Targeted(2)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit embryonic lethality. Mice heterozygous for a knock-out allele and a knock-in allele exhibit muscle weakness and reduced exercise endurance.
 
Human Diseases Modeled Using Mouse Sco2 (1)    Alleles Annotated to Human Diseases(2)   
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cellular copper ion homeostasis, copper ion homeostasis, ...
Component mitochondrial inner membrane, mitochondrion, ...
Function copper ion binding, metal ion binding
Expression
Literature Summary: (2 records)
Data Summary: Results (111)    Tissues (107)    Images (3)
Theiler Stages: 5, 22, 28
Assay TypeResults
Immunohistochemistry 7
RNA in situ 94
Northern blot 10
cDNA source data(3)
External Resources: GEO   ArrayExpress
Molecular
reagents
All nucleic(4) cDNA(4)
Microarray probesets(1)
Other database
links
Ensembl Gene ModelENSMUSG00000091780 (Evidence)
Entrez Gene100126824 (Evidence)
Consensus CDS ProjectCCDS49701.1
International Mouse Knockout Project StatusSco2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000091780 Ensembl Gene Model | MGI Sequence Detail 2180 C57BL/6J ±  kb
transcript ENSMUST00000167643 Ensembl | MGI Sequence Detail 1143 Not Applicable 
polypeptide ENSMUSP00000131943 Ensembl | MGI Sequence Detail 255 Not Applicable 

For the selected sequences
All sequences(13) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(11 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003782 Copper chaperone SCO1/SenC
InterPro IPR017276 Synthesis of cytochrome c oxidase, Sco1/Sco2
InterPro IPR012336 Thioredoxin-like fold
Protein Ontology PR:000014532 protein SCO2, mitochondrial
References (Earliest) J:122989 Visel A, et al., GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
(Latest) J:176080 Viscomi C, et al., In vivo correction of COX deficiency by activation of the AMPK/PGC-1alpha axis. Cell Metab. 2011 Jul 6;14(1):80-90
All references(18)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory