Sco2
Gene Detail

Symbol Name ID

Sco2 SCO cytochrome oxidase deficient homolog 2 (yeast) MGI:3818630

Feature Type

protein coding gene

Genetic Map

Chromosome 15

44.85 cM
Detailed Genetic Map ± 1 cM

Sequence Map

Chr15:89371639-89373818 bp, - strand From Ensembl annotation of GRCm38   2180 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68444  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: SCO1 protein
Gene Tree: Sco2

Human homologs

Human Homolog		SCO2, SCO2 cytochrome c oxidase assembly protein
NCBI Gene ID		9997
neXtProt AC		NX_O43819
Human Synonyms		CEMCOX1, SCO1L
Human Chr (Location)		22q13.33; chr22:50961997-50964868 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SCO2

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Mice homozygous for a knock-out allele exhibit embryonic lethality. Mice heterozygous for a knock-out allele and a knock-in allele exhibit muscle weakness and reduced exercise endurance.

 
Human Diseases Modeled Using Mouse Sco2 (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	cellular copper ion homeostasis, copper ion homeostasis, ...
Component	mitochondrial inner membrane, mitochondrion
Function	copper ion binding, metal ion binding

Expression

Literature Summary: (2 records)
Data Summary: Results (111)    Tissues (107)    Images (3)
Theiler Stages: 5, 22, 28

Assay Type	Results
Immunohistochemistry	7
RNA in situ	94
Northern blot	10

cDNA source data(3)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(4) cDNA(4)
Microarray probesets(1)

Other database links

Ensembl Gene Model	ENSMUSG00000091780 (Evidence)
Entrez Gene	100126824 (Evidence)
Consensus CDS Project	CCDS49701.1
International Mouse Knockout Project Status	Sco2

Sequences

Length	Strain/Species
genomic	ENSMUSG00000091780	Ensembl Gene Model | MGI Sequence Detail	2180	C57BL/6J
transcript	ENSMUST00000167643	Ensembl | MGI Sequence Detail	1143	Not Applicable
polypeptide	ENSMUSP00000131943	Ensembl | MGI Sequence Detail	255	Not Applicable

All sequences(13) RefSeq(2) UniProt(2)

Protein-related information

Resource	ID	Description
InterPro	IPR003782	Copper chaperone SCO1/SenC
InterPro	IPR017276	Synthesis of cytochrome c oxidase, Sco1/Sco2
InterPro	IPR012336	Thioredoxin-like fold
Protein Ontology	PR:000014532	protein SCO2, mitochondrial

References

(Earliest) J:122989 Visel A, et al., GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
(Latest) J:176080 Viscomi C, et al., In vivo correction of COX deficiency by activation of the AMPK/PGC-1alpha axis. Cell Metab. 2011 Jul 6;14(1):80-90
All references(17)