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Sco2 Gene Detail
Summary
  • Symbol
    Sco2
  • Name
    SCO2 cytochrome c oxidase assembly protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:3818630
    NCBI Gene: 100126824
  • Gene Overview
    MyGene.info: SCO2
Location & Maps
more
  • Sequence Map
    Chr15:89371639-89373818 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2180 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 44.85 cM
Homology
more
  • Human Ortholog
    SCO2, SCO2, cytochrome c oxidase assembly protein
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SCO2, SCO2, cytochrome c oxidase assembly protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CEMCOX1, MYP6, SCO1L
  • Links
    NCBI Gene ID: 9997
    neXtProt AC: NX_O43819

  • Chr Location
    22q13.33; chr22:50523568-50526439 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Sco2 mouse models; 2 with human SCO2 associations

Human Disease Mouse Models
       Mitochondrial Complex IV Deficiency   OMIM: 220110 View 1 model
       Cardioencephalomyopathy, Fatal Infantile, Due to Cytochrome C Oxidase Deficiency 1; CEMCOX1   OMIM: 604377
Myopia 6; MYP6   OMIM: 608908
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 3 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Radiation induced
    2
  • Targeted
    2
  • Genomic Mutations
    3 involving Sco2
  • Incidental Mutations
    APF
Mice homozygous for a knock-out allele exhibit embryonic lethality. Mice heterozygous for a knock-out allele and a knock-in allele exhibit muscle weakness and reduced exercise endurance.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Other Mouse Links
  • Other Vertebrate Links
    Xenbase sco2
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000091780 Ensembl Gene Model | MGI Sequence Detail 2180 C57BL/6J ±  kb
transcript ENSMUST00000167643 Ensembl | MGI Sequence Detail 1143 Not Applicable  
polypeptide ENSMUSP00000131943 Ensembl | MGI Sequence Detail 255 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    11 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000014532 protein SCO2, mitochondrial
  • InterPro Domains
    IPR003782 Copper chaperone SCO1/SenC
    IPR017276 Synthesis of cytochrome c oxidase, Sco1/Sco2
    IPR013766 Thioredoxin domain
    IPR012336 Thioredoxin-like fold
Molecular
Reagents
less
  • All nucleic 4
    cDNA 4

    Microarray probesets 1
References
more
  • Summaries
    All 20
    Developmental Gene Expression 2
    Diseases 2
    Gene Ontology 5
    Phenotypes 23
  • Earliest
    J:122989 Visel A, et al., GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
  • Latest
    J:233846 Du W, et al., SCO2 Mediates Oxidative Stress-Induced Glycolysis to Oxidative Phosphorylation Switch in Hematopoietic Stem Cells. Stem Cells. 2016 Apr;34(4):960-71

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory