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C1rb
Gene Detail
Symbol

Name
ID
C1rb
complement component 1, r subcomponent B
MGI:3779804
Synonyms
Gm8551, mC1rB
Feature Type
protein coding gene
Genetic Map
Chromosome 6
59.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr6:124570294-124581171 bp, + strand
From VEGA annotation of GRCm38

  10878 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1313  Vertebrate Homology Class
1 human; 2 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 2 western clawed frog

Protein SuperFamily: C1r-like complement-activating serine protease
Gene Tree: C1rb

Human
homologs
Human Homolog C1R, complement component 1, r subcomponent
NCBI Gene ID 715
neXtProt AC  NX_P00736
Human Chr (Location)  12p13
Disease Associations  (1) Diseases Associated with Human C1R
Gene Ontology
(GO)
classifications
Expression
External Resources: GEO   Expression Atlas
Molecular
reagents

Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000044915 (Evidence)
Ensembl Gene ModelENSMUSG00000098470 (Evidence)
Entrez Gene667277 (Evidence)
EC3.4.21.41
Consensus CDS ProjectCCDS71834.1
International Mouse Knockout Project StatusC1rb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044915 VEGA Gene Model | MGI Sequence Detail 10878 C57BL/6J ±  kb
transcript OTTMUST00000118064 VEGA | MGI Sequence Detail 2429 Not Applicable 
polypeptide OTTMUSP00000065944 VEGA | MGI Sequence Detail 706 Not Applicable 

For the selected sequences
All sequences(11) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(69 from dbSNP Build 137)    SNPs within 2kb including multiple locations(105)
Protein-related
information
ResourceIDDescription
InterPro IPR000859 CUB domain
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR024175 Peptidase S1A, complement C1r/C1S/mannan-binding
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR000436 Sushi/SCR/CCP
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000004896 complement C1r-B subcomponent
References
(Earliest) J:121092 Byun SJ, et al., IFN-gamma upregulates expression of the mouse complement C1rA gene in keratinocytes via IFN-regulatory factor-1. J Invest Dermatol. 2007 May;127(5):1187-96
All references(14)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory