Plscr5 MGI Mouse Gene Detail - MGI:3779462 - phospholipid scramblase family, member 5

Symbol

Plscr5
Name

phospholipid scramblase family, member 5

Feature Type

protein coding gene
IDs

MGI:3779462
NCBI Gene: 100504689
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr9:92074989-92091825 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 48.33 cM
Mapping Data

1 experiment

SNPs within 2kb

636 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3779462	protein coding gene	Chr9:92068569-92094589 (+)
129S1/SvImJ	ENSMUSG00200005059	protein coding gene	Chr9:89199814-89216656 (+)
A/J	ENSMUSG00195006986	protein coding gene	Chr9:88454420-88471267 (+)
AKR/J	ENSMUSG00220019644	protein coding gene	Chr9:88834995-88851841 (+)
BALB/cJ	ENSMUSG00180007031	protein coding gene	Chr9:88780153-88797004 (+)
C3H/HeJ	ENSMUSG00175004379	protein coding gene	Chr9:89091563-89108412 (+)
C57BL/6NJ	ENSMUSG00215008044	protein coding gene	Chr9:89087187-89104027 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032522	protein coding gene	Chr9:88026953-88043797 (+)
CAST/EiJ	ENSTCUG00005003713	protein coding gene	Chr9:89014539-89031362 (+)
CBA/J	ENSMUSG00210005448	protein coding gene	Chr9:88968602-88985611 (+)
DBA/2J	ENSMUSG00185001643	protein coding gene	Chr9:89154535-89171295 (+)
FVB/NJ	ENSMUSG00205004540	protein coding gene	Chr9:89292828-89309592 (+)
JF1/MsJ	ENSUMUG00000027762	protein coding gene	Chr9:88873609-88890396 (+)
LP/J	ENSMUSG00230008127	protein coding gene	Chr9:89305807-89322649 (+)
NOD/ShiLtJ	ENSMUSG00190010763	protein coding gene	Chr9:88749597-88766436 (+)
NZO/HlLtJ	ENSMUSG00225015644	protein coding gene	Chr9:89455395-89472404 (+)
PWK/PhJ	ENSLUMG00010002910	protein coding gene	Chr9:88843628-88860330 (+)
SPRET/EiJ	ENSMSPG00010002240	protein coding gene	Chr9:90603447-90620188 (+)
WSB/EiJ	ENSIUOG00005003555	protein coding gene	Chr9:88210609-88227362 (+)

Human Ortholog

PLSCR5, phospholipid scramblase family member 5

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PLSCR5, phospholipid scramblase family member 5
Links

HGNC:19952

NCBI Gene ID: 389158

UniProt: A0PG75
Chr Location

3q24; chr3:146576555-146605346 (-) GRCh38

MGI Vertebrate Homology

Plscr5 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: PLSCR5
Gene Tree

Plscr5

less

Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

4
Genomic Mutations

1 involving Plscr5
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele display progressive hearing loss with cochlear outer hair cell stereocilia degeneration. Milder hearing loss is seen in heterozygous null mice.

less

All GO Annotations

5
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

1
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

less

All Sequences

28
RefSeq

4
UniProt

1
CCDS

CCDS57688.1

Ensembl

ENSMUSG00000095654 (Evidence)
NCBI Gene

100504689

			Length	Strain/Species	Flank
genomic	ENSMUSG00000095654	Ensembl Gene Model \| MGI Sequence Detail	16837	C57BL/6J	± kb
transcript	ENSMUST00000179751	Ensembl \| MGI Sequence Detail	1191	Not Applicable
polypeptide	ENSMUSP00000136181	Ensembl \| MGI Sequence Detail	274	Not Applicable

less

UniProt

1 Sequence
InterPro Domains

IPR005552 Scramblase

IPR025659 Tubby-like, C-terminal

less

All nucleic 1

cDNA 1

Summaries

All 19

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 8
Earliest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Latest

J:377967 Roome RB, et al., Ontogeny of the spinal cord dorsal horn. Science. 2026 Jan 8;391(6781):eadx5781

TSS for Plscr5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr86490	Chr9:92075141-92075153 (+)	158 bp
Tssr86491	Chr9:92075154-92075171 (+)	174 bp
Tssr86492	Chr9:92075205-92075210 (+)	219 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24