About   Help   FAQ
Tomt
Gene Detail
 Symbol
Name
ID
Tomt
transmembrane O-methyltransferase
MGI:3769724
Synonyms Comt2, F930017I19Rik
Feature Type protein coding gene
Genetic Map
Chromosome 7
54.68 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:101898373-101903785 bp, - strand
From VEGA annotation of GRCm38

  5413 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:19664  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

Gene Tree: Tomt

Human
homologs
Human Homolog LRTOMT, leucine rich transmembrane and O-methyltransferase domain containing
NCBI Gene ID 220074
neXtProt AC  NX_Q8WZ04, NX_Q96E66
Human Synonyms  DFNB63, LRRC51
Human Chr (Location)  11q13.4; chr11:72080331-72110782 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human LRTOMT
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Chemically induced (ENU)(1) Gene trapped(4) Targeted(1)
Incidental mutations (data from APF )
 
Mice homozygous for a mutation of this gene exhibit marked hyperactivity, bidirectional circling and head-tossing. These behaviors are suppressed during sleep and nursing. Homozygous mutant males exhibit heightened male:male aggression.
 
Human Diseases Modeled Using Mouse Tomt (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Tomt interacts with 269 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process auditory receptor cell development, catecholamine catabolic process, ...
Component cytoplasm
Function catechol O-methyltransferase activity, methyltransferase activity, ...
Expression
cDNA source data(1)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(1) cDNA(1)
Other database
links
VEGA Gene ModelOTTMUSG00000025104 (Evidence)
Ensembl Gene ModelENSMUSG00000078630 (Evidence)
Entrez Gene791260 (Evidence)
DoTSDT.94151042
EC2.1.1.6
Consensus CDS ProjectCCDS40044.1
International Mouse Knockout Project StatusTomt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025104 VEGA Gene Model | MGI Sequence Detail 5413 C57BL/6J ±  kb
transcript OTTMUST00000061764 VEGA | MGI Sequence Detail 2793 Not Applicable 
polypeptide OTTMUSP00000030364 VEGA | MGI Sequence Detail 258 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(6) UniProt(1)
Polymorphisms SNPs within 2kb(37 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR025782 Catechol O-methyltransferase
InterPro IPR002935 O-methyltransferase, family 3
Protein Ontology PR:000016933 transmembrane O-methyltransferase
References (Earliest) J:86521 Hoebe K, et al., Lps2: a new locus required for responses to lipopolysaccharide, revealed by germline mutagenesis and phenotypic screening. J Endotoxin Res. 2003;9(4):250-5
(Latest) J:142754 Hansen GM, et al., Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Genome Res. 2008 Oct;18(10):1670-9
All references(22)
Disease annotation references (1)
Other
accession IDs
MGI:3707696

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/23/2014
MGI 5.19
The Jackson Laboratory