Tomt
Gene Detail

Symbol Name ID

Tomt transmembrane O-methyltransferase MGI:3769724

Synonyms

Comt2, F930017I19Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 7

54.68 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr7:101898373-101903785 bp, - strand From VEGA annotation of GRCm38   5413 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:19664  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Tomt

Human homologs

Human Homolog		LRTOMT, leucine rich transmembrane and 0-methyltransferase domain containing
NCBI Gene ID		220074
neXtProt AC		NX_Q8WZ04, NX_Q96E66
Human Synonyms		DFNB63, LRRC51
Human Chr (Location)		11q13.4; chr11:71791377-71821828 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human LRTOMT

Alleles and phenotypes

All alleles(6) : Targeted(1) Gene trapped(4) Chemically induced(1)
 

Mice homozygous for a mutation of this gene exhibit marked hyperactivity, bidirectional circling and head-tossing. These behaviors are suppressed during sleep and nursing. Homozygous mutant males exhibit heightened male:male aggression.

 
Human Diseases Modeled Using Mouse Tomt (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	auditory receptor cell development, catecholamine catabolic process, ...
Component	cytoplasm
Function	catechol O-methyltransferase activity, methyltransferase activity, ...

Expression

cDNA source data(2)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(2) cDNA(2)

Other database links

VEGA Gene Model	OTTMUSG00000025104 (Evidence)
Ensembl Gene Model	ENSMUSG00000078630 (Evidence)
Entrez Gene	791260 (Evidence)
UniGene	475469
DoTS	DT.94151042
EC	2.1.1.6
Consensus CDS Project	CCDS40044.1
International Mouse Knockout Project Status	Tomt

Sequences

Length	Strain/Species
genomic	OTTMUSG00000025104	VEGA Gene Model | MGI Sequence Detail	5413	C57BL/6J
transcript	OTTMUST00000061764	VEGA | MGI Sequence Detail	2793	Not Applicable
polypeptide	OTTMUSP00000030364	VEGA | MGI Sequence Detail	258	Not Applicable

All sequences(16) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(25 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR025782	Catechol O-methyltransferase
InterPro	IPR002935	O-methyltransferase, family 3
Protein Ontology	PR:000016933	transmembrane O-methyltransferase

References

(Earliest) J:86521 Hoebe K, et al., Lps2: a new locus required for responses to lipopolysaccharide, revealed by germline mutagenesis and phenotypic screening. J Endotoxin Res. 2003;9(4):250-5
(Latest) J:142754 Hansen GM, et al., Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Genome Res. 2008 Oct;18(10):1670-9
All references(23)

Other accession IDs

MGI:3707696