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Tomt Gene Detail
Summary
  • Symbol
    Tomt
  • Name
    transmembrane O-methyltransferase
  • Synonyms
    Comt2, F930017I19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3769724
    NCBI Gene: 791260
Location & Maps
more
  • Sequence Map
    Chr7:101898373-101903785 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5413 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 54.68 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    LRTOMT, leucine rich transmembrane and O-methyltransferase domain containing
  • Vertebrate Orthologs
    7
  • Human Ortholog
    LRTOMT, leucine rich transmembrane and O-methyltransferase domain containing
    Orthology source: HomoloGene
  • Synonyms
    CFAP111, DFNB63, LRRC51
  • Links
    NCBI Gene ID: 220074
    neXtProt AC: NX_Q8WZ04, NX_Q96E66

  • Chr Location
    11q13.4; chr11:72080331-72110782 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Tomt mouse models

Human Disease Mouse Models
       Deafness, Autosomal Recessive 63; DFNB63   OMIM: 611451 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 1 allele in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Gene trapped
    4
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    2 involving Tomt
  • Incidental Mutations
    APF
Mice homozygous for a mutation of this gene exhibit marked hyperactivity, bidirectional circling and head-tossing. These behaviors are suppressed during sleep and nursing. Homozygous mutant males exhibit heightened male:male aggression.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025104 VEGA Gene Model | MGI Sequence Detail 5413 C57BL/6J ±  kb
transcript OTTMUST00000061764 VEGA | MGI Sequence Detail 2793 Not Applicable  
polypeptide OTTMUSP00000030364 VEGA | MGI Sequence Detail 258 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    37 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000016933 transmembrane O-methyltransferase
  • EC
  • InterPro Domains
    IPR002935 O-methyltransferase, family 3
    IPR029063 S-adenosyl-L-methionine-dependent methyltransferase
    IPR033025 Transmembrane O-methyltransferase
Molecular
Reagents
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  • All nucleic 1
    cDNA 1
Other
Accession IDs
less
MGI:3707696
References
more
  • Summaries
    All 20
    Diseases 1
    Gene Ontology 3
    Phenotypes 15
  • Earliest
    J:86521 Hoebe K, et al., Lps2: a new locus required for responses to lipopolysaccharide, revealed by germline mutagenesis and phenotypic screening. J Endotoxin Res. 2003;9(4):250-5
  • Latest
    J:142754 Hansen GM, et al., Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Genome Res. 2008 Oct;18(10):1670-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory