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Tomt Gene Detail
Summary
  • Symbol
    Tomt
  • Name
    transmembrane O-methyltransferase
  • Synonyms
    Comt2, F930017I19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3769724
    NCBI Gene: 791260
  • Gene Overview
    MyGene.info: LRTOMT
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:101899803-101906405 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 54.68 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    35 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3769724
protein coding gene Chr7:101898370-101906405 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032592
protein coding gene Chr7:104914252-104922238 (-)
A/J MGP_AJ_G0032568
protein coding gene Chr7:102241150-102249136 (-)
AKR/J MGP_AKRJ_G0032504
protein coding gene Chr7:104688526-104696512 (-)
BALB/cJ MGP_BALBcJ_G0032579
protein coding gene Chr7:101940707-101948693 (-)
C3H/HeJ MGP_C3HHeJ_G0032293
protein coding gene Chr7:105062488-105070483 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033076
protein coding gene Chr7:108866521-108874507 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030070
protein coding gene Chr7:104605068-104613277 (-)
CAST/EiJ MGP_CASTEiJ_G0031619
protein coding gene Chr7:96618912-96626906 (-)
CBA/J MGP_CBAJ_G0032259
protein coding gene Chr7:112636255-112644250 (-)
DBA/2J MGP_DBA2J_G0032411
protein coding gene Chr7:100572647-100580620 (-)
FVB/NJ MGP_FVBNJ_G0032367
protein coding gene Chr7:100351429-100360182 (-)
LP/J MGP_LPJ_G0032500
protein coding gene Chr7:106231294-106239280 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032401
protein coding gene Chr7:113965294-113973395 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033098
protein coding gene Chr7:103959140-103967127 (-)
PWK/PhJ MGP_PWKPhJ_G0031337
protein coding gene Chr7:93684545-93692849 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031181
protein coding gene Chr7:91255468-91265569 (-)
WSB/EiJ MGP_WSBEiJ_G0031736
protein coding gene Chr7:104646232-104654218 (-)



Homology
more
  • Human Ortholog
    LRTOMT, leucine rich transmembrane and O-methyltransferase domain containing
  • Vertebrate Orthologs
    7
  • Human Ortholog
    LRTOMT, leucine rich transmembrane and O-methyltransferase domain containing
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CFAP111, DFNB63, LRRC51
  • Links
    NCBI Gene ID: 220074
    neXtProt AC: NX_Q8WZ04, NX_Q96E66
    UniProt: Q8WZ04, Q96E66

  • Chr Location
    11q13.4; chr11:72079982-72110782 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Tomt mouse models; 1 with human LRTOMT associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 1 allele in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Gene trapped
    4
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    2 involving Tomt
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Mice homozygous for a mutation of this gene exhibit marked hyperactivity, bidirectional circling and head-tossing. These behaviors are suppressed during sleep and nursing. Homozygous mutant males exhibit heightened male:male aggression.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 791260 NCBI Gene Model | MGI Sequence Detail 6603 C57BL/6J ±  kb
transcript NM_001282088 RefSeq | MGI Sequence Detail 1358 C57BL/6  
polypeptide A1Y9I9 UniProt | EBI | MGI Sequence Detail 258 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 1
    cDNA 1
Other
Accession IDs
less
MGI:3707696
References
more
  • Summaries
    All 33
    Diseases 1
    Gene Ontology 8
    Phenotypes 17
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:257320 Erickson T, et al., Integration of Tmc1/2 into the mechanotransduction complex in zebrafish hair cells is regulated by Transmembrane O-methyltransferase (Tomt). Elife. 2017 May 23;6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory