Tmem35b MGI Mouse Gene Detail - MGI:3758095

Symbol

Tmem35b
Name

transmembrane protein 35B
Synonyms

Zmym6nb

Feature Type

protein coding gene
IDs

MGI:3758095
NCBI Gene: 100039968
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr4:127019836-127023453 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 61.29 cM

SNPs within 2kb

63 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3758095	protein coding gene	Chr4:127017484-127023453 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028793	protein coding gene	Chr4:128857931-128863850 (+)
A/J	MGP_AJ_G0028752	protein coding gene	Chr4:123777457-123783376 (+)
AKR/J	MGP_AKRJ_G0028705	protein coding gene	Chr4:127176427-127182380 (+)
BALB/cJ	MGP_BALBcJ_G0028775	protein coding gene	Chr4:124345411-124351330 (+)
C3H/HeJ	MGP_C3HHeJ_G0028489	protein coding gene	Chr4:127255612-127261531 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029217	protein coding gene	Chr4:133764940-133770893 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026490	protein coding gene	Chr4:116899536-116905552 (+)
CAST/EiJ	MGP_CASTEiJ_G0027922	protein coding gene	Chr4:125369271-125375226 (+)
CBA/J	MGP_CBAJ_G0028455	protein coding gene	Chr4:137016041-137021960 (+)
DBA/2J	MGP_DBA2J_G0028604	protein coding gene	Chr4:124220116-124226035 (+)
FVB/NJ	MGP_FVBNJ_G0028571	protein coding gene	Chr4:122884799-122890718 (+)
LP/J	MGP_LPJ_G0028705	protein coding gene	Chr4:129146659-129152578 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028597	protein coding gene	Chr4:142016896-142022815 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029255	protein coding gene	Chr4:127550700-127556619 (+)
PWK/PhJ	MGP_PWKPhJ_G0027643	protein coding gene	Chr4:120717989-120723916 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027469	protein coding gene	Chr4:123365365-123371396 (+)
WSB/EiJ	MGP_WSBEiJ_G0028002	protein coding gene	Chr4:127660625-127666578 (+)

Human Ortholog

TMEM35B, transmembrane protein 35B

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMEM35B, transmembrane protein 35B
Synonyms

ZMYM6NB
Links

HGNC:40021

NCBI Gene ID: 100506144

neXtProt AC: NX_Q8NCS4

UniProt: Q8NCS4
Chr Location

chr1:34981380-34985347 (-) GRCh38

MGI Vertebrate Homology

Tmem35b stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: TMEM35B
Gene Tree

Tmem35b

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

1
Radiation induced

1
Targeted

1
Genomic Mutations

4 involving Tmem35b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

20 strains or lines available

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All GO Annotations

1
GO References

1

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

2

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmem35b

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All Sequences

32
RefSeq

3
UniProt

3
CCDS

CCDS38882.1

Ensembl

ENSMUSG00000070737 (Evidence)
NCBI Gene

100039968

			Length	Strain/Species	Flank
genomic	100039968	NCBI Gene Model \| MGI Sequence Detail	3618	C57BL/6J	± kb
transcript	NM_001099319	RefSeq \| MGI Sequence Detail	1139	C57BL/6
polypeptide	Q3U0Y2	UniProt \| EBI \| MGI Sequence Detail	150	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000031368 transmembrane protein 35B

(term hierarchy)
InterPro Domains

IPR032808 DoxX family

IPR040399 Transmembrane protein 35A/B

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All nucleic 4

cDNA 4

Microarray probesets 1

Summaries

All 24

Gene Ontology 1

Phenotypes 11
Earliest

J:84714 Nishijima I, et al., Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p. Genesis. 2003 Jul;36(3):142-8
Latest

J:148802 Boles MK, et al., A mouse chromosome 4 balancer ENU-mutagenesis screen isolates eleven lethal lines. BMC Genet. 2009;10:12

TSS for Tmem35b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr39043	Chr4:127019827-127019874 (+)	15 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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