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Pnp2
Gene Detail
Symbol

Name
ID
Pnp2
purine-nucleoside phosphorylase 2
MGI:3712328
Feature Type
protein coding gene
Genetic Map
Chromosome 14
26.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr14:50955992-50964749 bp, + strand
From VEGA annotation of GRCm38

  8758 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:227  Vertebrate Homology Class
1 human; 2 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 2 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: PNP
Protein SuperFamily: PurNPase
Gene Tree: Pnp2

Human
homologs
PNP, purine nucleoside phosphorylase
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 4860
neXtProt AC: NX_P00491

Human Synonyms: NP, PRO1837, PUNP

Human Chr (Location): 14q13.1; chr14:20469379-20478006 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PNP

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Pnp2 interacts with 47 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process purine-containing compound salvage
Component cytoplasm, extracellular exosome, ...
Function drug binding, nucleoside binding, ...
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(2)
Other mouse links: GEO   Expression Atlas
Molecular
reagents
All nucleic(3) cDNA(2) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000034665 (Evidence)
Ensembl Gene Model ENSMUSG00000068417 (Evidence)
Entrez Gene 667034 (Evidence)
DoTS DT.94378553
EC 2.4.2.1
Consensus CDS Project CCDS49479.1
International Mouse Phenotyping Consortium Status Pnp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034665 VEGA Gene Model | MGI Sequence Detail 8758 C57BL/6J ±  kb
transcript OTTMUST00000087986 VEGA | MGI Sequence Detail 1372 Not Applicable 
polypeptide OTTMUSP00000047930 VEGA | MGI Sequence Detail 305 Not Applicable 

For the selected sequences
All sequences(14) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(119 from dbSNP Build 137)    SNPs within 2kb including multiple locations(185)
Protein-related
information
ResourceIDDescription
InterPro IPR000845 Nucleoside phosphorylase domain
InterPro IPR001369 PNP/MTAP phosphorylase
InterPro IPR011268 Purine nucleoside phosphorylase
InterPro IPR011270 Purine nucleoside phosphorylase I, inosine/guanosine-specific
InterPro IPR018099 Purine phosphorylase, family 2, conserved site
References
(Earliest) J:122989 Visel A, et al., GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(20)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory