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Pnp2
Gene Detail
 Symbol
Name
ID
Pnp2
purine-nucleoside phosphorylase 2
MGI:3712328
Feature Type protein coding gene
Genetic Map
Chromosome 14
26.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr14:50955992-50964749 bp, + strand
From VEGA annotation of GRCm38

  8758 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:227  Vertebrate Homology Class
1 human; 2 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 2 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: PurNPase
Gene Tree: Pnp2

Human
homologs
Human Homolog PNP, purine nucleoside phosphorylase
NCBI Gene ID 4860
neXtProt AC  NX_P00491
Human Synonyms  NP, PRO1837, PUNP
Human Chr (Location)  14q13.1; chr14:20469379-20478006 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human PNP
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Pnp2 interacts with 47 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process biological_process
Component cytoplasm, extracellular region, ...
Function drug binding, nucleoside binding, ...
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Images (1)
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(2)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(3) cDNA(2) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000034665 (Evidence)
Ensembl Gene ModelENSMUSG00000068417 (Evidence)
Entrez Gene667034 (Evidence)
DoTSDT.94378553
EC2.4.2.1
Consensus CDS ProjectCCDS49479.1
International Mouse Knockout Project StatusPnp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034665 VEGA Gene Model | MGI Sequence Detail 8758 C57BL/6J ±  kb
transcript OTTMUST00000087986 VEGA | MGI Sequence Detail 1372 Not Applicable 
polypeptide OTTMUSP00000047930 VEGA | MGI Sequence Detail 305 Not Applicable 

For the selected sequences
All sequences(14) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(119 from dbSNP Build 137)    SNPs within 2kb including multiple locations(185)
Protein-related
information
ResourceIDDescription
InterPro IPR000845 Nucleoside phosphorylase domain
InterPro IPR001369 PNP/MTAP phosphorylase
InterPro IPR011268 Purine nucleoside phosphorylase
InterPro IPR011270 Purine nucleoside phosphorylase I, inosine/guanosine-specific
InterPro IPR018099 Purine phosphorylase, family 2, conserved site
References (Earliest) J:122989 Visel A, et al., GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(21)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory