Parp10 MGI Mouse Gene Detail - MGI:3712326 - poly (ADP-ribose) polymerase family, member 10

Symbol

Parp10
Name

poly (ADP-ribose) polymerase family, member 10

Feature Type

protein coding gene
IDs

MGI:3712326
NCBI Gene: 671535
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr15:76117195-76127640 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 35.57 cM
Mapping Data

1 experiment

SNPs within 2kb

1 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3712326	protein coding gene	Chr15:76115374-76127641 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021978	protein coding gene	Chr15:76294698-76306982 (-)
A/J	MGP_AJ_G0021936	protein coding gene	Chr15:73516019-73530016 (-)
AKR/J	MGP_AKRJ_G0021919	protein coding gene	Chr15:75510338-75523227 (-)
BALB/cJ	MGP_BALBcJ_G0021945	protein coding gene	Chr15:73538973-73551882 (-)
C3H/HeJ	MGP_C3HHeJ_G0021717	protein coding gene	Chr15:75557182-75569489 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022385	protein coding gene	Chr15:79141824-79159904 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019914	protein coding gene	Chr15:70179780-70192203 (-)
CAST/EiJ	MGP_CASTEiJ_G0021236	protein coding gene	Chr15:76356855-76371661 (-)
CBA/J	MGP_CBAJ_G0021684	protein coding gene	Chr15:81645356-81659319 (-)
DBA/2J	MGP_DBA2J_G0021809	protein coding gene	Chr15:73055421-73067704 (-)
FVB/NJ	MGP_FVBNJ_G0021790	protein coding gene	Chr15:72101743-72114002 (-)
LP/J	MGP_LPJ_G0021880	protein coding gene	Chr15:76385488-76400173 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021814	protein coding gene	Chr15:86963657-86975891 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022405	protein coding gene	Chr15:75754289-75766577 (-)
PWK/PhJ	MGP_PWKPhJ_G0020977	protein coding gene	Chr15:73200512-73212901 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020817	protein coding gene	Chr15:75476025-75488481 (-)
WSB/EiJ	MGP_WSBEiJ_G0021288	protein coding gene	Chr15:75844804-75858981 (-)

Human Ortholog

PARP10, poly(ADP-ribose) polymerase family member 10

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PARP10, poly(ADP-ribose) polymerase family member 10
Synonyms

ARTD10
Links

HGNC:25895

NCBI Gene ID: 84875

neXtProt AC: NX_Q53GL7

UniProt: Q53GL7
Chr Location

8q24.3; chr8:143977153-144012772 (-) GRCh38

MGI Vertebrate Homology

Parp10 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PARP10
Gene Tree

Parp10

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References

1 with disease annotations

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

3
Gene trapped

1
Radiation induced

2
Targeted

1
Genomic Mutations

5 involving Parp10
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

27 strains or lines available

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All GO Annotations

40
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

11
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

49
RefSeq

4
UniProt

2
CCDS

CCDS49650.1

Ensembl

ENSMUSG00000063268 (Evidence)
NCBI Gene

671535

			Length	Strain/Species	Flank
genomic	671535	NCBI Gene Model \| MGI Sequence Detail	10446	C57BL/6J	± kb
transcript	NM_001163576	RefSeq \| MGI Sequence Detail	3411	C57BL/6
polypeptide	Q8CIE4	UniProt \| EBI \| MGI Sequence Detail	960	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000012290 protein mono-ADP-ribosyltransferase PARP10

(term hierarchy)
EC

2.4.2.-
InterPro Domains

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR034464 PARP-10, RNA recognition motif 1 and 2

IPR012317 Poly(ADP-ribose) polymerase, catalytic domain

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All nucleic 11

cDNA 11

Microarray probesets 3

Summaries

All 50

Developmental Gene Expression 1

Diseases 1

Gene Ontology 8

Phenotypes 26
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:310115 Gao XQ, et al., The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N(6)-methyladenosine methylation of Parp10 mRNA. Nat Cell Biol. 2020 Nov;22(11):1319-1331

TSS for Parp10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr134958	Chr15:76127601-76127648 (-)	15 bp
Tssr134957	Chr15:76127579-76127596 (-)	52 bp
Tssr134956	Chr15:76127370-76127381 (-)	264 bp
Tssr134955	Chr15:76127332-76127366 (-)	291 bp
Tssr134954	Chr15:76127309-76127330 (-)	320 bp
Tssr134953	Chr15:76126845-76126857 (-)	789 bp
Tssr134952	Chr15:76126818-76126827 (-)	817 bp
Tssr134951	Chr15:76125484-76125489 (-)	2,153 bp
Tssr4636	Chr15:76119144-76119181 (-)	8,477 bp
Tssr134950	Chr15:76118001-76118016 (-)	9,631 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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