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Smpd5 Gene Detail
Summary
  • Symbol
    Smpd5
  • Name
    sphingomyelin phosphodiesterase 5
  • Synonyms
    1700010G02Rik, Gm10345
  • Feature Type
    protein coding gene
  • IDs
    MGI:3709877
    NCBI Gene: 100503915
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:76178548-76181096 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 35.67 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    17 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3709877
 protein coding gene Chr15:76178478-76181096 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021981
 protein coding gene Chr15:76363721-76366183 (+)
A/J MGP_AJ_G0021939
 protein coding gene Chr15:73581168-73583630 (+)
AKR/J MGP_AKRJ_G0021922
 protein coding gene Chr15:75578475-75580937 (+)
BALB/cJ MGP_BALBcJ_G0021948
 protein coding gene Chr15:73608186-73610648 (+)
C3H/HeJ MGP_C3HHeJ_G0021720
 protein coding gene Chr15:75623620-75626082 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022388
 protein coding gene Chr15:79215104-79217566 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019917
 protein coding gene Chr15:70243391-70245843 (+)
CAST/EiJ MGP_CASTEiJ_G0021239
 protein coding gene Chr15:76422579-76425041 (+)
CBA/J MGP_CBAJ_G0021687
 protein coding gene Chr15:81714678-81717140 (+)
DBA/2J MGP_DBA2J_G0021812
 protein coding gene Chr15:73118240-73120702 (+)
FVB/NJ MGP_FVBNJ_G0021793
 protein coding gene Chr15:72166070-72168532 (+)
LP/J MGP_LPJ_G0021883
 protein coding gene Chr15:76453637-76456099 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021817
 protein coding gene Chr15:87042143-87044605 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022408
 protein coding gene Chr15:75822897-75825359 (+)
PWK/PhJ MGP_PWKPhJ_G0020980
 protein coding gene Chr15:73265413-73267875 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020820
 protein coding gene Chr15:75544270-75546729 (+)
WSB/EiJ MGP_WSBEiJ_G0021291
 protein coding gene Chr15:75911661-75914123 (+)



Homology
more
  • Human Ortholog
    SMPD5, sphingomyelin phosphodiesterase 5 (pseudogene)
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SMPD5, sphingomyelin phosphodiesterase 5 (pseudogene)
  • Synonyms
    MA-nSMase
  • Links
    NCBI Gene ID: 392275

  • Chr Location
    8q24.3; chr8:144048677-144051220 (+)  GRCh38.p7
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    3
  • Gene trapped
    1
  • Radiation induced
    2
  • Genomic Mutations
    5 involving Smpd5
  • Find Mice (IMSR)
    12 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    672
  • cDNA Data
    4
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000071724 Ensembl Gene Model | MGI Sequence Detail 2549 C57BL/6J ±  kb
transcript ENSMUST00000163991 Ensembl | MGI Sequence Detail 1909 Not Applicable  
polypeptide ENSMUSP00000134687 Ensembl | MGI Sequence Detail 483 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • EC
    3.1.4.12
  • InterPro Domains
    IPR036691 Endonuclease/exonuclease/phosphatase superfamily
    IPR017766 Sphingomyelinase C/phospholipase C
Molecular
Reagents
less
  • All nucleic 4
    cDNA 4

    Microarray probesets 2
References
more
  • Summaries
    All 40
    Diseases 1
    Gene Ontology 5
    Phenotypes 25
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:285676 Suzuki A, et al., Genes and microRNAs associated with mouse cleft palate: A systematic review and bioinformatics analysis. Mech Dev. 2018 Apr;150:21-27
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
08/03/2022
MGI 6.21 		The Jackson Laboratory