Gsta5 Gene Detail

Summary

• Symbol
  Gsta5
• Name
  glutathione S-transferase alpha 5
• Synonyms
  Gm10639

• Feature Type
  protein coding gene
• IDs
  MGI:3704339
  NCBI Gene: 100042314
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Chr9:78197210-78212807 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 9, 43.65 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  109 from dbSNP Build 142
• Strain Annotations
  11

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3704339	protein coding gene	Chr9:78197205-78212807 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035061	protein coding gene	Chr9:78705404-78797433 (+)
A/J	MGP_AJ_G0035042	protein coding gene	Chr9:76009954-76020825 (+)
AKR/J	no annotation
BALB/cJ	no annotation
C3H/HeJ	no annotation
C57BL/6NJ	no annotation
CAROLI/EiJ	MGP_CAROLIEiJ_G0032464	protein coding gene	Chr9:75243372-75249740 (-)
CAST/EiJ	no annotation
CBA/J	MGP_CBAJ_G0034714	protein coding gene	Chr9:83619259-83643363 (+)
DBA/2J	no annotation
FVB/NJ	MGP_FVBNJ_G0034819	protein coding gene	Chr9:74969720-74986597 (-)
LP/J	MGP_LPJ_G0034956	protein coding gene	Chr9:79001220-79014798 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034857	protein coding gene	Chr9:84813819-84837355 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035577	protein coding gene	Chr9:78061367-78088591 (-)
PWK/PhJ	no annotation
SPRET/EiJ	MGP_SPRETEiJ_G0033603	protein coding gene	Chr9:78260087-78270011 (-)
WSB/EiJ	MGP_WSBEiJ_G0034176	protein coding gene	Chr9:77888435-77896040 (+)

Homology

• Human Ortholog
  GSTA1, glutathione S-transferase alpha 1

• Vertebrate Orthologs
  9

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  GSTA1, glutathione S-transferase alpha 1
  
• Synonyms
  GST2, GSTA1-1, GST-epsilon, GTH1
• Links
  HGNC:4626

  NCBI Gene ID: 2938

  neXtProt AC: NX_P08263

  UniProt: P08263

  
  
• Chr Location
  6p12.2; chr6:52791371-52803860 (-)  GRCh38

---

• Human Ortholog
  GSTA2, glutathione S-transferase alpha 2
  
• Synonyms
  GST2, GSTA2-2, GTA2, GTH2
• Links
  HGNC:4627

  NCBI Gene ID: 2939

  neXtProt AC: NX_P09210

  UniProt: P09210

  
  
• Chr Location
  6p12.2; chr6:52750087-52763475 (-)  GRCh38

---

• Human Ortholog
  GSTA3, glutathione S-transferase alpha 3
  
• Synonyms
  GSTA3-3, GTA3
• Links
  HGNC:4628

  NCBI Gene ID: 2940

  neXtProt AC: NX_Q16772

  UniProt: Q16772

  
  
• Chr Location
  6p12.2; chr6:52896639-52909698 (-)  GRCh38

---

• Human Ortholog
  GSTA5, glutathione S-transferase alpha 5
  
• Links
  HGNC:19662

  NCBI Gene ID: 221357

  neXtProt AC: NX_Q7RTV2

  UniProt: Q7RTV2

  
  
• Chr Location
  6p12.2; chr6:52831655-52846245 (-)  GRCh38

---

• MGI Vertebrate Homology
  Gsta5 stringent orthology
  4 human;1 mouse;3 rat;2 zebrafish
  
• HCOP
  vertebrate homology predictions: GSTA1, GSTA2, GSTA3, GSTA5
• Gene Tree
  Gsta5
  

Human Diseases

• Diseases
  2 with human GSTA1 associations

				Human Disease	Mouse Models
				asthma IDs asthma       DOID:2841 DOID:12703 DOID:13829 DOID:13830 DOID:2840 DOID:5783 ICD10CM:J45 ICD9CM:493 ICD9CM:493.9 KEGG:05310 MESH:D001249 NCI:C28397 OMIM:600807 UMLS_CUI:C0004096
				ovarian cancer IDs ovarian cancer       DOID:2394 DOID:0060070 DOID:2144 DOID:9595 ICD10CM:C56 ICD9CM:183.0 MESH:D010051 NCI:C4984 NCI:C7431 OMIM:167000 OMIM:607893 ORDO:213500 ORDO:213517 UMLS_CUI:C0919267 UMLS_CUI:C1140680 UMLS_CUI:C1299247

Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  9 phenotype references
  

• All Mutations and Alleles
  4
• Chemically induced (other)
  1
• Gene trapped
  2
• Radiation induced
  1
• Genomic Mutations
  2 involving Gsta5
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  10 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  24
• GO References
  3

Expression

• Assay Results
  707
• Tissues
  1
• cDNA Data
  9
• Literature Summary
  1

Images

Tissue x Stage Matrix

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  23
• RefSeq
  2
• UniProt
  2
• CCDS
  CCDS52866.1

• Ensembl
  ENSMUSG00000074179 (Evidence)
• NCBI Gene
  100042314

Representative Sequences			Length	Strain/Species
genomic	100042314	NCBI Gene Model | MGI Sequence Detail	15598	C57BL/6J
transcript	NM_001122660	RefSeq | MGI Sequence Detail	874	Not Specified
polypeptide	NP_001116132	RefSeq | MGI Sequence Detail	222	Not Specified

Protein
Information

• UniProt
  2 Sequences
• EC
  2.5.1.18
• InterPro Domains
  IPR003080 Glutathione S-transferase, alpha class
  IPR004046 Glutathione S-transferase, C-terminal
  IPR036282 Glutathione S-transferase, C-terminal domain superfamily
  IPR010987 Glutathione S-transferase, C-terminal-like
  IPR004045 Glutathione S-transferase, N-terminal
  IPR040079 Glutathione transferase family
  IPR036249 Thioredoxin-like superfamily

Molecular
Reagents

• All nucleic 9

  cDNA 9

  
  

  Microarray probesets 1

References

• Summaries
  All 22

  Developmental Gene Expression 1

  Gene Ontology 3

  Phenotypes 9
• Earliest
  J:12013 Russell LB, Definition of functional units in a small chromosomal segment of the mouse and its use in interpreting the nature of radiation-induced mutations. Mutat Res. 1971 Jan;11(1):107-23
• Latest
  J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14