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Zar1l Gene Detail
Summary
  • Symbol
    Zar1l
  • Name
    zygote arrest 1-like
  • Synonyms
    LOC545824
  • Feature Type
    protein coding gene
  • IDs
    MGI:3690051
    NCBI Gene: 545824
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr5:150430520-150441629 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 89.51 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    44 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3690051
protein coding gene Chr5:150430520-150441659 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030409
protein coding gene Chr5:156446044-156458492 (-)
A/J MGP_AJ_G0030382
protein coding gene Chr5:149740437-149752347 (-)
AKR/J MGP_AKRJ_G0030309
protein coding gene Chr5:154363008-154374111 (-)
BALB/cJ MGP_BALBcJ_G0030391
protein coding gene Chr5:151000482-151012748 (-)
C3H/HeJ MGP_C3HHeJ_G0030105
protein coding gene Chr5:155362346-155376854 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030846
protein coding gene Chr5:162148764-162166551 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028059
protein coding gene Chr5:144072846-144082795 (-)
CAST/EiJ MGP_CASTEiJ_G0029507
protein coding gene Chr5:155013172-155029150 (-)
CBA/J MGP_CBAJ_G0030083
protein coding gene Chr5:168988591-169006257 (-)
DBA/2J MGP_DBA2J_G0030227
protein coding gene Chr5:149391708-149403951 (-)
FVB/NJ MGP_FVBNJ_G0030181
protein coding gene Chr5:148638316-148650063 (-)
LP/J MGP_LPJ_G0030314
protein coding gene Chr5:157104460-157116872 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030217
protein coding gene Chr5:171036202-171049294 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030876
protein coding gene Chr5:154319513-154333088 (-)
PWK/PhJ MGP_PWKPhJ_G0029221
protein coding gene Chr5:148557296-148569404 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029057
protein coding gene Chr5:151608874-151619764 (-)
WSB/EiJ MGP_WSBEiJ_G0029584
protein coding gene Chr5:155131652-155142802 (-)



Homology
more
  • Human Ortholog
    ZAR1L, zygote arrest 1 like
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZAR1L, zygote arrest 1 like
  • Synonyms
    Z3CXXC7, ZAR2
  • Links
    NCBI Gene ID: 646799
    neXtProt AC: NX_A6NP61
    UniProt: A6NP61

  • Chr Location
    13q13.1; chr13:32303771-32311954 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit slightly slower germinal vesicle breakdown and first polar body release but normal fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000056586 Ensembl Gene Model | MGI Sequence Detail 11110 C57BL/6J ±  kb
transcript ENSMUST00000118769 Ensembl | MGI Sequence Detail 895 Not Applicable  
polypeptide ENSMUSP00000114116 Ensembl | MGI Sequence Detail 291 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR027377 Zinc-binding domain
    IPR026775 Zygote arrest protein 1
Molecular
Reagents
less
  • All nucleic 4
    cDNA 4
References
more
  • Summaries
    All 15
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 3
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:282460 Rong Y, et al., ZAR1 and ZAR2 are required for oocyte meiotic maturation by regulating the maternal transcriptome and mRNA translational activation. Nucleic Acids Res. 2019 Dec 2;47(21):11387-11402

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
11/26/2022
MGI 6.22
The Jackson Laboratory