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Try10 Gene Detail
Summary
  • Symbol
    Try10
  • Name
    trypsin 10
  • Synonyms
    trypsinogen 10
  • Feature Type
    protein coding gene
  • IDs
    MGI:3687012
    NCBI Gene: 436522
  • Gene Overview
    MyGene.info: PRSS1
Location & Maps
more
  • Sequence Map
    Chr6:41354105-41357914 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3810 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 19.48 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    PRSS1, protease, serine 1
  • Vertebrate Orthologs
    5
  • Human Ortholog
    PRSS1, protease, serine 1
    Orthology source: HomoloGene
  • Synonyms
    TRP1, TRY1, TRY4, TRYP1
  • Links
    NCBI Gene ID: 5644
    neXtProt AC: NX_P07477

  • Chr Location
    7q34; chr7:142740235-142753076 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human PRSS1 associations

Human Disease Mouse Models
       Pancreatitis, Hereditary; PCTT   OMIM: 167800
Trypsinogen Deficiency   OMIM: 614044
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051419 VEGA Gene Model | MGI Sequence Detail 3810 C57BL/6J ±  kb
transcript OTTMUST00000129976 VEGA | MGI Sequence Detail 860 Not Applicable  
polypeptide OTTMUSP00000069738 VEGA | MGI Sequence Detail 246 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    29 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR001314 Peptidase S1A, chymotrypsin family
    IPR009003 Peptidase S1, PA clan
    IPR001254 Serine proteases, trypsin domain
    IPR018114 Serine proteases, trypsin family, histidine active site
    IPR033116 Serine proteases, trypsin family, serine active site
Molecular
Reagents
less
  • All nucleic 48
    cDNA 48

    Microarray probesets 1
References
more
  • Summaries
    All 12
    Gene Ontology 2
  • Earliest
    J:53168 Bairoch A, et al., SWISS-PROT Annotated protein sequence database. Database Release. 1999;
  • Latest
    J:57747 MGI Genome Annotation Group and UniGene Staff, MGI-UniGene Interconnection Effort. Database Download. 2015;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory