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Try10 Gene Detail
Summary
  • Symbol
    Try10
  • Name
    trypsin 10
  • Synonyms
    trypsinogen 10
  • Feature Type
    protein coding gene
  • IDs
    MGI:3687012
    NCBI Gene: 436522
  • Gene Overview
    MyGene.info: PRSS1
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:41354105-41357914 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 19.48 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    29 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3687012
protein coding gene Chr6:41354105-41357944 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030624
protein coding gene Chr6:39851158-39859967 (+)
A/J MGP_AJ_G0030599
protein coding gene Chr6:38176304-38179196 (+)
AKR/J MGP_AKRJ_G0030526
protein coding gene Chr6:39387372-39388753 (+)
BALB/cJ MGP_BALBcJ_G0030609
protein coding gene Chr6:38328312-38332025 (+)
C3H/HeJ MGP_C3HHeJ_G0030324
protein coding gene Chr6:39452147-39455764 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031062
protein coding gene Chr6:40833425-40839159 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0029724
protein coding gene Chr6:39245588-39249824 (+)
CBA/J MGP_CBAJ_G0030298
protein coding gene Chr6:42515859-42522663 (+)
DBA/2J MGP_DBA2J_G0030444
protein coding gene Chr6:38011285-38012494 (+)
FVB/NJ MGP_FVBNJ_G0030396
protein coding gene Chr6:37672213-37676258 (+)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0030434
protein coding gene Chr6:44760687-44867186 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031091
protein coding gene Chr6:39296907-39301409 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0029273
protein coding gene Chr6:38999136-39010915 (+)
WSB/EiJ MGP_WSBEiJ_G0029800
protein coding gene Chr6:39230750-39240845 (+)



Homology
more
  • Human Ortholog
    PRSS1, serine protease 1
  • Vertebrate Orthologs
    5
  • Human Ortholog
    PRSS1, serine protease 1
    Orthology source: HomoloGene
  • Synonyms
    TRP1, TRY1, TRY4, TRYP1
  • Links
    NCBI Gene ID: 5644
    neXtProt AC: NX_P07477
    UniProt: P07477

  • Chr Location
    7q34; chr7:142740235-142753076 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human PRSS1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000071521 Ensembl Gene Model | MGI Sequence Detail 3810 C57BL/6J ±  kb
transcript ENSMUST00000072103 Ensembl | MGI Sequence Detail 860 Not Applicable  
polypeptide ENSMUSP00000071976 Ensembl | MGI Sequence Detail 246 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR001314 Peptidase S1A, chymotrypsin family
    IPR009003 Peptidase S1, PA clan
    IPR001254 Serine proteases, trypsin domain
    IPR018114 Serine proteases, trypsin family, histidine active site
    IPR033116 Serine proteases, trypsin family, serine active site
Molecular
Reagents
less
  • All nucleic 48
    cDNA 48

    Microarray probesets 1
References
more
  • Summaries
    All 12
    Gene Ontology 3
  • Earliest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62
  • Latest
    J:265607 Naba A, et al., Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep. 2017 Jan 10;7:40495

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory