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Ctcfl Gene Detail
Summary
  • Symbol
    Ctcfl
  • Name
    CCCTC-binding factor (zinc finger protein)-like
  • Synonyms
    Boris, OTTMUSG00000016680
  • Feature Type
    protein coding gene
  • IDs
    MGI:3652571
    NCBI Gene: 664799
  • Gene Overview
    MyGene.info: CTCFL
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:173093609-173119525 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 95.74 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    188 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3652571
protein coding gene Chr2:173093508-173119525 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026953
protein coding gene Chr2:179340716-179368059 (-)
A/J MGP_AJ_G0026920
protein coding gene Chr2:171801340-171828448 (-)
AKR/J MGP_AKRJ_G0026891
protein coding gene Chr2:176984070-177015416 (-)
BALB/cJ MGP_BALBcJ_G0026929
protein coding gene Chr2:172202276-172228071 (-)
C3H/HeJ MGP_C3HHeJ_G0026671
protein coding gene Chr2:177373503-177401671 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027376
protein coding gene Chr2:184513119-184541198 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024746
protein coding gene Chr2:165042471-165064951 (-)
CAST/EiJ MGP_CASTEiJ_G0026129
protein coding gene Chr2:178066171-178092164 (-)
CBA/J MGP_CBAJ_G0026648
protein coding gene Chr2:191404023-191442067 (-)
DBA/2J MGP_DBA2J_G0026786
protein coding gene Chr2:170899417-170924974 (-)
FVB/NJ MGP_FVBNJ_G0026752
protein coding gene Chr2:169517272-169541707 (-)
LP/J MGP_LPJ_G0026887
protein coding gene Chr2:179278171-179304916 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026771
protein coding gene Chr2:194344924-194373645 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027433
protein coding gene Chr2:176998590-177026324 (-)
PWK/PhJ MGP_PWKPhJ_G0025866
protein coding gene Chr2:170691332-170717356 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025666
protein coding gene Chr2:175998553-176024554 (-)
WSB/EiJ MGP_WSBEiJ_G0026202
protein coding gene Chr2:177955399-177981151 (-)



Homology
more
  • Human Ortholog
    CTCFL, CCCTC-binding factor like
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CTCFL, CCCTC-binding factor like
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BORIS, CT27, CTCF-T, dJ579F20.2, HMGB1L1
  • Links
    NCBI Gene ID: 140690
    neXtProt AC: NX_Q8NI51
    UniProt: Q8NI51

  • Chr Location
    20q13.31; chr20:57495965-57525652 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit small testes, delayed spermatid development, and increased male germ cell apoptosis without affecting fertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000070495 Ensembl Gene Model | MGI Sequence Detail 25917 C57BL/6J ±  kb
    transcript ENSMUST00000094287 Ensembl | MGI Sequence Detail 3217 Not Applicable  
    polypeptide ENSMUSP00000091845 Ensembl | MGI Sequence Detail 636 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR036236 Zinc finger C2H2 superfamily
      IPR013087 Zinc finger C2H2-type
    Molecular
    Reagents
    less
    • All nucleic 3
      cDNA 2
      Primer pair 1

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:3650163
    References
    more
    • Summaries
      All 27
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 4
    • Earliest
      J:112166 Loukinov DI, et al., BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma. Proc Natl Acad Sci U S A. 2002 May 14;99(10):6806-11
    • Latest
      J:228230 Sati L, et al., Expression of the CTCFL Gene during Mouse Embryogenesis Causes Growth Retardation, Postnatal Lethality, and Dysregulation of the Transforming Growth Factor beta Pathway. Mol Cell Biol. 2015 Oct;35(19):3436-45

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory