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Rad21l Gene Detail
Summary
  • Symbol
    Rad21l
  • Name
    RAD21-like (S. pombe)
  • Synonyms
    Gm14160
  • Feature Type
    protein coding gene
  • IDs
    MGI:3652039
    NCBI Gene: 668929
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr2:151645404-151668533 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 74.83 cM
Strain
Comparison
more
  • SNPs within 2kb
    126 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3652039
protein coding gene Chr2:151644366-151670622 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026643
protein coding gene Chr2:156131641-156157766 (-)
A/J MGP_AJ_G0026609
protein coding gene Chr2:149925889-149950923 (-)
AKR/J MGP_AKRJ_G0026579
protein coding gene Chr2:154294384-154317507 (-)
BALB/cJ MGP_BALBcJ_G0026618
protein coding gene Chr2:150235106-150260078 (-)
C3H/HeJ MGP_C3HHeJ_G0026361
protein coding gene Chr2:154682837-154707370 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027067
protein coding gene Chr2:160690160-160721468 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024438
protein coding gene Chr2:143543192-143566884 (-)
CAST/EiJ MGP_CASTEiJ_G0025822
protein coding gene Chr2:154903796-154935630 (-)
CBA/J MGP_CBAJ_G0026339
protein coding gene Chr2:166567677-166595075 (-)
DBA/2J MGP_DBA2J_G0026475
protein coding gene Chr2:149143217-149166066 (-)
FVB/NJ MGP_FVBNJ_G0026440
protein coding gene Chr2:147585103-147608371 (-)
LP/J MGP_LPJ_G0026579
protein coding gene Chr2:156305482-156330071 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026462
protein coding gene Chr2:170734581-170765176 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027122
protein coding gene Chr2:154169073-154196943 (-)
PWK/PhJ MGP_PWKPhJ_G0025556
protein coding gene Chr2:148666088-148692144 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025359
protein coding gene Chr2:153002801-153030752 (-)
WSB/EiJ MGP_WSBEiJ_G0025892
protein coding gene Chr2:155086386-155112395 (-)



Homology
more
  • Human Ortholog
    RAD21L1, RAD21 cohesin complex component like 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    RAD21L1, RAD21 cohesin complex component like 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    dJ545L17.2, RAD21L
  • Links
    NCBI Gene ID: 642636
    neXtProt AC: NX_Q9H4I0
    UniProt: Q9H4I0

  • Chr Location
    20p13; chr20:1226043-1255876 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 3 alleles in 4 genetic backgrounds
    4 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit male infertility and reduced female fertility associated with abnormal meiosis and synaptonemal complex.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000074704 Ensembl Gene Model | MGI Sequence Detail 23130 C57BL/6J ±  kb
    transcript ENSMUST00000180195 Ensembl | MGI Sequence Detail 1659 Not Applicable  
    polypeptide ENSMUSP00000136918 Ensembl | MGI Sequence Detail 552 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000013668 double-strand-break repair protein rad21-like protein 1
    • InterPro Domains
      IPR039781 Rad21/Rec8-like protein
      IPR006909 Rad21/Rec8-like protein, C-terminal, eukaryotic
      IPR006910 Rad21/Rec8-like protein, N-terminal
      IPR036390 Winged helix DNA-binding domain superfamily
    Molecular
    Reagents
    less

    • Microarray probesets 2
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 6
      Gene Ontology 10
      Phenotypes 18
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:280261 Bhattacharyya T, et al., Prdm9 and Meiotic Cohesin Proteins Cooperatively Promote DNA Double-Strand Break Formation in Mammalian Spermatocytes. Curr Biol. 2019 Mar 18;29(6):1002-1018.e7

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    05/19/2020
    MGI 6.15
    The Jackson Laboratory