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Rad21l Gene Detail
Summary
  • Symbol
    Rad21l
  • Name
    RAD21-like (S. pombe)
  • Synonyms
    Gm14160
  • Feature Type
    protein coding gene
  • IDs
    MGI:3652039
    NCBI Gene: 668929
Location & Maps
more
  • Sequence Map
    Chr2:151645404-151668533 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23130 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 74.83 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    RAD21L1, RAD21 cohesin complex component like 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    RAD21L1, RAD21 cohesin complex component like 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    dJ545L17.2, RAD21L
  • Links
    NCBI Gene ID: 642636
    neXtProt AC: NX_Q9H4I0

  • Chr Location
    20p13; chr20:1226043-1261279 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 2 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    3 involving Rad21l
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit male infertility and reduced female fertility associated with abnormal meiosis and synaptonemal complex.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015829 VEGA Gene Model | MGI Sequence Detail 23130 C57BL/6J ±  kb
transcript OTTMUST00000117004 VEGA | MGI Sequence Detail 1659 Not Applicable  
polypeptide OTTMUSP00000065448 VEGA | MGI Sequence Detail 552 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    126 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000013668 double-strand-break repair protein rad21-like protein 1
  • InterPro Domains
    IPR023093 Rad21/Rec8-like protein, C-terminal
    IPR006909 Rad21/Rec8-like protein, C-terminal, eukaryotic
    IPR006910 Rad21/Rec8-like protein, N-terminal
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
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  • Microarray probesets 2
References
more
  • Summaries
    All 28
    Developmental Gene Expression 6
    Gene Ontology 9
    Phenotypes 10
  • Earliest
    J:169787 Lee J, et al., RAD21L, a novel cohesin subunit implicated in linking homologous chromosomes in mammalian meiosis. J Cell Biol. 2011 Jan 24;192(2):263-76
  • Latest
    J:231231 Abby E, et al., Implementation of meiosis prophase I programme requires a conserved retinoid-independent stabilizer of meiotic transcripts. Nat Commun. 2016;7:10324

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory