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Spint3 Gene Detail
Summary
  • Symbol
    Spint3
  • Name
    serine peptidase inhibitor, Kunitz type, 3
  • Synonyms
    Gm14315
  • Feature Type
    protein coding gene
  • IDs
    MGI:3651470
    NCBI Gene: 629747
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:164411641-164415355 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 85.20 cM
Strain
Comparison
more
  • SNPs within 2kb
    238 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3651470
 protein coding gene Chr2:164411615-164415379 (-)
129S1/SvImJ ENSMUSG00200015882
 protein coding gene Chr2:161298964-161302743 (-)
A/J ENSMUSG00195019134
 protein coding gene Chr2:161631822-161635674 (-)
AKR/J ENSMUSG00220013415
 protein coding gene Chr2:160961393-160965131 (-)
BALB/cJ ENSMUSG00180047493
 protein coding gene Chr2:161085566-161089426 (-)
C3H/HeJ ENSMUSG00175046061
 protein coding gene Chr2:161831916-161835657 (-)
C57BL/6NJ ENSMUSG00215024253
 protein coding gene Chr2:161283522-161287293 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024651
 protein coding gene Chr2:156506503-156510233 (-)
CAST/EiJ ENSTCUG00005043470
 protein coding gene Chr2:160203206-160207065 (-)
CBA/J ENSMUSG00210016764
 protein coding gene Chr2:161766217-161770072 (-)
DBA/2J ENSMUSG00185045627
 protein coding gene Chr2:161499108-161502851 (-)
FVB/NJ ENSMUSG00205037734
 protein coding gene Chr2:160519967-160523713 (-)
JF1/MsJ ENSUMUG00000013398
 protein coding gene Chr2:161143565-161147419 (-)
LP/J ENSMUSG00230041516
 protein coding gene Chr2:163060065-163063868 (-)
NOD/ShiLtJ ENSMUSG00190027663
 protein coding gene Chr2:161171047-161174900 (-)
NZO/HlLtJ ENSMUSG00225052355
 protein coding gene Chr2:171061430-171065173 (-)
PWK/PhJ ENSLUMG00010042567
 protein coding gene Chr2:161046489-161050305 (-)
SPRET/EiJ ENSMSPG00010026001
 protein coding gene Chr2:163808790-163812395 (-)
WSB/EiJ ENSIUOG00005044696
 protein coding gene Chr2:160892088-160895854 (-)



Homology
more
  • Human Ortholog
    SPINT3, serine peptidase inhibitor, Kunitz type 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPINT3, serine peptidase inhibitor, Kunitz type 3
  • Synonyms
    HKIB9
  • Links
    NCBI Gene ID: 10816
    UniProt: P49223

  • Chr Location
    chr20:45512461-45515622 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotype references
Mice homozygous for a null allele exhibit normal male fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 629747 NCBI Gene Model | MGI Sequence Detail 3715 C57BL/6J ±  kb
transcript NM_001177401 RefSeq | MGI Sequence Detail 507 C57BL/6  
polypeptide NP_001170872 RefSeq | MGI Sequence Detail 88 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR002223 Pancreatic trypsin inhibitor Kunitz domain
    IPR036880 Pancreatic trypsin inhibitor Kunitz domain superfamily
    IPR020901 Proteinase inhibitor I2, Kunitz, conserved site
    IPR050098 Tissue factor pathway inhibitor/Kunitz-type serine protease inhibitor-like
Molecular
Reagents
less
  • All nucleic 4
    cDNA 4
References
more
  • Summaries
    All 19
    Gene Ontology 3
    Phenotypes 5
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:295177 Robertson MJ, et al., Large-scale discovery of male reproductive tract-specific genes through analysis of RNA-seq datasets. BMC Biol. 2020 Aug 19;18(1):103
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory