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Faxdc2 Gene Detail
Summary
  • Symbol
    Faxdc2
  • Name
    fatty acid hydroxylase domain containing 2
  • Synonyms
    Gm12248
  • Feature Type
    protein coding gene
  • IDs
    MGI:3651124
    NCBI Gene: 676527
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:57954508-57983977 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 35.63 cM
Strain
Comparison
more
  • SNPs within 2kb
    831 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3651124
 protein coding gene Chr11:57954378-57983977 (-)
129S1/SvImJ ENSMUSG00200034920
 protein coding gene Chr11:54956625-54984717 (-)
A/J ENSMUSG00195034712
 protein coding gene Chr11:54890725-54918817 (-)
AKR/J ENSMUSG00220037583
 protein coding gene Chr11:55053014-55081109 (-)
BALB/cJ ENSMUSG00180047975
 protein coding gene Chr11:54973023-55001124 (-)
C3H/HeJ ENSMUSG00175047570
 protein coding gene Chr11:54925788-54953877 (-)
C57BL/6NJ ENSMUSG00215038942
 protein coding gene Chr11:54744364-54773948 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0037089
 pseudogene Chr11:52901185-52910978 (-)
CAST/EiJ ENSTCUG00005039012
 protein coding gene Chr11:54461644-54491278 (-)
CBA/J ENSMUSG00210027790
 protein coding gene Chr11:54777428-54805519 (-)
DBA/2J ENSMUSG00185036999
 protein coding gene Chr11:54962295-54990383 (-)
FVB/NJ ENSMUSG00205040678
 protein coding gene Chr11:54830168-54858270 (-)
JF1/MsJ ENSUMUG00000022638
 protein coding gene Chr11:55307074-55336663 (-)
LP/J ENSMUSG00230044236
 protein coding gene Chr11:56163486-56191577 (-)
NOD/ShiLtJ ENSMUSG00190030546
 protein coding gene Chr11:55016293-55044373 (-)
NZO/HlLtJ ENSMUSG00225032431
 protein coding gene Chr11:58179169-58207253 (-)
PWK/PhJ ENSLUMG00010027493
 protein coding gene Chr11:54762821-54791960 (-)
SPRET/EiJ ENSMSPG00010028036
 protein coding gene Chr11:55554864-55583077 (-)
WSB/EiJ ENSIUOG00005030308
 protein coding gene Chr11:54818991-54847051 (-)



Homology
more
  • Human Ortholog
    FAXDC2, fatty acid hydroxylase domain containing 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FAXDC2, fatty acid hydroxylase domain containing 2
  • Synonyms
    C5orf4
  • Links
    NCBI Gene ID: 10826
    UniProt: Q96IV6

  • Chr Location
    5q33.2; chr5:154818492-154859252 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      34
    • RefSeq
      4
    • UniProt
      3
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 676527 NCBI Gene Model | MGI Sequence Detail 29470 C57BL/6J ±  kb
    transcript NM_001378239 RefSeq | MGI Sequence Detail 1254 C57BL/6  
    polypeptide NP_001365168 RefSeq | MGI Sequence Detail 313 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR006694 Fatty acid hydroxylase
      IPR050307 Sterol desaturase-related
    Other
    Accession IDs
    less
    MGI:7439155
    References
    more
    • Summaries
      All 22
      Gene Ontology 6
      Phenotypes 9
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:371188 Madan B, et al., The cholesterol biosynthesis enzyme FAXDC2 couples Wnt/beta-catenin to RTK/MAPK signaling. J Clin Invest. 2024 Jan 23;134(6)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory