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Prcd Gene Detail
Summary
  • Symbol
    Prcd
  • Name
    photoreceptor disc component
  • Synonyms
    Gm11744
  • Feature Type
    protein coding gene
  • IDs
    MGI:3649529
    NCBI Gene: 100038570
  • Gene Overview
    MyGene.info: PRCD
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:116653889-116668389 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 81.46 cM
Strain
Comparison
more
  • SNPs within 2kb
    114 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3649529
protein coding gene Chr11:116653534-116668389 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019435
protein coding gene Chr11:120798986-120814770 (+)
A/J MGP_AJ_G0019403
protein coding gene Chr11:115508383-115523749 (+)
AKR/J MGP_AKRJ_G0019374
protein coding gene Chr11:118944850-118966522 (+)
BALB/cJ MGP_BALBcJ_G0019378
protein coding gene Chr11:115904648-115919866 (+)
C3H/HeJ MGP_C3HHeJ_G0019184
protein coding gene Chr11:119304674-119322793 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019827
protein coding gene Chr11:124493782-124511995 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017451
protein coding gene Chr11:112521732-112535777 (+)
CAST/EiJ MGP_CASTEiJ_G0018739
protein coding gene Chr11:120681087-120696226 (+)
CBA/J MGP_CBAJ_G0019155
protein coding gene Chr11:129410686-129426295 (+)
DBA/2J MGP_DBA2J_G0019267
protein coding gene Chr11:114934192-114949111 (+)
FVB/NJ MGP_FVBNJ_G0019259
protein coding gene Chr11:114444992-114462467 (+)
LP/J MGP_LPJ_G0019337
protein coding gene Chr11:121182415-121198571 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019292
protein coding gene Chr11:128443109-128458120 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019866
protein coding gene Chr11:119608752-119623239 (+)
PWK/PhJ MGP_PWKPhJ_G0018503
protein coding gene Chr11:116262272-116277306 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018296
protein coding gene Chr11:119359570-119373929 (+)
WSB/EiJ MGP_WSBEiJ_G0018791
protein coding gene Chr11:119576889-119592325 (+)



Homology
more
  • Human Ortholog
    PRCD, photoreceptor disc component
  • Human Ortholog
    PRCD, photoreceptor disc component
    Orthology source: HGNC
  • Synonyms
    RP36
  • Links
    NCBI Gene ID: 768206
    neXtProt AC: NX_Q00LT1
    UniProt: Q00LT1

  • Chr Location
    17q25.1; chr17:76527586-76555339 (+)  GRCh38.p7

  • HCOP
    human homology predictions: PRCD
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human PRCD associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show a defect in photoreceptor disc morphogenesis resulting in vesicle accumulation in the inter-photoreceptor space and a slow progressive retinal rod cell degeneration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 100038570 NCBI Gene Model | MGI Sequence Detail 14501 C57BL/6J ±  kb
transcript NM_001163318 RefSeq | MGI Sequence Detail 816 C57BL/6  
polypeptide Q00LT2 UniProt | EBI | MGI Sequence Detail 53 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 2
References
more
  • Summaries
    All 24
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:276708 Spencer WJ, et al., PRCD is essential for high-fidelity photoreceptor disc formation. Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):13087-13096

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory