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Ces1a Gene Detail
Summary
  • Symbol
    Ces1a
  • Name
    carboxylesterase 1A
  • Synonyms
    Gm4976
  • Feature Type
    protein coding gene
  • IDs
    MGI:3648919
    NCBI Gene: 244595
  • Member of
    Ces1 cluster
  • Gene Overview
    MyGene.info: CES1
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr8:93020214-93048192 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 44.99 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    441 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3648919
protein coding gene Chr8:93020214-93048192 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033940
protein coding gene Chr8:94344830-94371669 (-)
A/J MGP_AJ_G0033923
protein coding gene Chr8:90627949-90654896 (-)
AKR/J MGP_AKRJ_G0033849
protein coding gene Chr8:93174016-93200856 (-)
BALB/cJ MGP_BALBcJ_G0033915
protein coding gene Chr8:90782555-90809391 (-)
C3H/HeJ MGP_C3HHeJ_G0033625
protein coding gene Chr8:93890494-93917332 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034436
protein coding gene Chr8:97813239-97842020 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031377
protein coding gene Chr8:84552567-84580028 (-)
CAST/EiJ MGP_CASTEiJ_G0032957
protein coding gene Chr8:93451751-93479964 (-)
CBA/J MGP_CBAJ_G0033601
protein coding gene Chr8:101068543-101095376 (-)
DBA/2J MGP_DBA2J_G0033755
protein coding gene Chr8:90168116-90195213 (-)
FVB/NJ MGP_FVBNJ_G0033702
protein coding gene Chr8:89108082-89134903 (-)
LP/J MGP_LPJ_G0033847
protein coding gene Chr8:94464555-94491439 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033744
protein coding gene Chr8:103417535-103444277 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034454
protein coding gene Chr8:93291958-93318790 (-)
PWK/PhJ MGP_PWKPhJ_G0032659
protein coding gene Chr8:89516909-89545089 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032496
protein coding gene Chr8:92142544-92172071 (-)
WSB/EiJ MGP_WSBEiJ_G0033069
protein coding gene Chr8:93750142-93777737 (-)



Homology
more
  • Human Ortholog
    CES1, carboxylesterase 1
  • Vertebrate Orthologs
    2
  • Human Ortholog
    CES1, carboxylesterase 1
    Orthology source: HGNC
  • Synonyms
    ACAT, CE-1, CEH, CES2, hCE-1, HMSE, HMSE1, PCE-1, REH, SES1, TGH
  • Links
    NCBI Gene ID: 1066
    neXtProt AC: NX_P23141
    UniProt: P23141

  • Chr Location
    16q12.2; chr16:55802851-55833186 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 244595 NCBI Gene Model | MGI Sequence Detail 27979 C57BL/6J ±  kb
transcript NM_001013764 RefSeq | MGI Sequence Detail 1980 C57BL/6  
polypeptide NP_001013786 RefSeq | MGI Sequence Detail 563 C57BL/6  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 2
    cDNA 2

    Microarray probesets 1
References
more
  • Summaries
    All 16
    Gene Ontology 1
    Phenotypes 4
  • Earliest
    J:164863 Holmes RS, et al., Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Mamm Genome. 2010 Oct;21(9-10):427-41
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/16/2019
MGI 6.13
The Jackson Laboratory