Slc38a6 MGI Mouse Gene Detail - MGI:3648156 - solute carrier family 38, member 6

Symbol

Slc38a6
Name

solute carrier family 38, member 6
Synonyms

EG625098

Feature Type

protein coding gene
IDs

MGI:3648156
NCBI Gene: 625098
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr12:73333553-73400823 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 30.42 cM
Mapping Data

2 experiments

SNPs within 2kb

1610 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3648156	protein coding gene	Chr12:73333553-73408772 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019836	protein coding gene	Chr12:73182205-73250156 (+)
A/J	MGP_AJ_G0019794	protein coding gene	Chr12:70445760-70511656 (+)
AKR/J	MGP_AKRJ_G0019769	protein coding gene	Chr12:72580664-72644843 (+)
BALB/cJ	MGP_BALBcJ_G0019774	protein coding gene	Chr12:70925872-70989555 (+)
C3H/HeJ	MGP_C3HHeJ_G0019579	protein coding gene	Chr12:73010995-73080097 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020226	protein coding gene	Chr12:75460203-75531671 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017844	protein coding gene	Chr12:67888657-67951891 (+)
CAST/EiJ	MGP_CASTEiJ_G0019131	protein coding gene	Chr12:67808345-67879402 (+)
CBA/J	MGP_CBAJ_G0019549	protein coding gene	Chr12:78336238-78413232 (+)
DBA/2J	MGP_DBA2J_G0019665	protein coding gene	Chr12:70340617-70403290 (+)
FVB/NJ	MGP_FVBNJ_G0019652	protein coding gene	Chr12:69188738-69251458 (+)
LP/J	MGP_LPJ_G0019737	protein coding gene	Chr12:73206528-73269007 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019691	protein coding gene	Chr12:81470530-81538217 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020261	protein coding gene	Chr12:72065986-72133809 (+)
PWK/PhJ	MGP_PWKPhJ_G0018896	protein coding gene	Chr12:64659007-64749777 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018691	protein coding gene	Chr12:66489015-66558759 (+)
WSB/EiJ	MGP_WSBEiJ_G0019182	protein coding gene	Chr12:72656934-72723601 (+)

Human Ortholog

SLC38A6, solute carrier family 38 member 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC38A6, solute carrier family 38 member 6
Synonyms

NAT-1, SNAT6
Links

HGNC:19863

NCBI Gene ID: 145389

UniProt: Q8IZM9
Chr Location

14q23.1; chr14:60981114-61114316 (+) GRCh38

MGI Vertebrate Homology

Slc38a6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC38A6
Gene Tree

Slc38a6

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Phenotype Summary

11 phenotype references

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

2
Targeted

3
Genomic Mutations

1 involving Slc38a6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

34 strains or lines available

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All GO Annotations

14
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

724
Tissues

8
cDNA Data

13
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

GEISHA SLC38A6

Xenbase slc38a6

ZFIN slc38a6

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All Sequences

71
RefSeq

22
UniProt

5
CCDS

CCDS49088.1

Ensembl

ENSMUSG00000044712 (Evidence)
NCBI Gene

625098

			Length	Strain/Species	Flank
genomic	ENSMUSG00000044712	Ensembl Gene Model \| MGI Sequence Detail	67271	C57BL/6J	± kb
transcript	ENSMUST00000140523	Ensembl \| MGI Sequence Detail	3032	Not Applicable
polypeptide	ENSMUSP00000120810	Ensembl \| MGI Sequence Detail	457	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000031782 solute carrier family 38 member 6

(term hierarchy)
InterPro Domains

IPR013057 Amino acid transporter, transmembrane domain

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All nucleic 14

cDNA 13

Primer pair 1

Microarray probesets 2

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MGI:2145022

Summaries

All 33

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 11
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Slc38a6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr113786	Chr12:73333572-73333579 (+)	23 bp
Tssr113787	Chr12:73333597-73333638 (+)	65 bp
Tssr113788	Chr12:73333642-73333687 (+)	112 bp
Tssr113789	Chr12:73383403-73383414 (+)	49,856 bp
Tssr113790	Chr12:73383465-73383485 (+)	49,922 bp
Tssr113791	Chr12:73383531-73383544 (+)	49,985 bp
Tssr113792	Chr12:73383563-73383592 (+)	50,025 bp
Tssr113793	Chr12:73399227-73399241 (+)	65,681 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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