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Ighv3-5 Gene Detail
Summary
  • Symbol
    Ighv3-5
  • Name
    immunoglobulin heavy variable 3-5
  • Synonyms
    Gm7112
  • Feature Type
    gene segment
  • IDs
    MGI:3648045
    NCBI Gene: 633457
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:114226272-114226570 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 62.33 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3648045
gene segment Chr12:114226272-114226707 (-)
129S1/SvImJ MGP_129S1SvImJ_G0000063
gene segment Chr12:116886244-116886680 (-)
A/J MGP_AJ_G0000067
gene segment Chr12:112461509-112461945 (-)
AKR/J MGP_AKRJ_G0000067
gene segment Chr12:115728145-115728580 (-)
BALB/cJ MGP_BALBcJ_G0000064
gene segment Chr12:112960665-112961101 (-)
C3H/HeJ MGP_C3HHeJ_G0000064
gene segment Chr12:116081351-116081786 (-)
C57BL/6NJ MGP_C57BL6NJ_G0000087
gene segment Chr12:120525233-120525668 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0000042
gene segment Chr12:108826467-108826909 (-)
CAST/EiJ MGP_CASTEiJ_G0000064
gene segment Chr12:110872798-110873234 (-)
CBA/J MGP_CBAJ_G0000062
gene segment Chr12:125086540-125086975 (-)
DBA/2J MGP_DBA2J_G0000066
gene segment Chr12:112007606-112008042 (-)
FVB/NJ MGP_FVBNJ_G0000060
gene segment Chr12:110703669-110704105 (-)
LP/J MGP_LPJ_G0000070
gene segment Chr12:116869171-116869606 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0000068
gene segment Chr12:128357331-128357766 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0000080
gene segment Chr12:115131306-115131741 (-)
PWK/PhJ MGP_PWKPhJ_G0000054
gene segment Chr12:106644738-106645294 (-)
SPRET/EiJ MGP_SPRETEiJ_G0000048
gene segment Chr12:109423213-109423649 (-)
WSB/EiJ MGP_WSBEiJ_G0000064
gene segment Chr12:116177355-116177791 (-)



Homology
more
  • Human Ortholog
    IGHV4-28, immunoglobulin heavy variable 4-28
  • Vertebrate Orthologs
    15
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IGHV4-28, immunoglobulin heavy variable 4-28
  • Synonyms
    IGHV428, VH
  • Links
    NCBI Gene ID: 28400
    UniProt: A0A0C4DH34

  • Chr Location
    14q32.33; chr14:106324254-106324688 (-)  GRCh38.p7

  • Human Ortholog
    IGHV4-30-2, immunoglobulin heavy variable 4-30-2
  • Synonyms
    IGHV4-3, IGHV4302
  • Links
    NCBI Gene ID: 28398

  • Chr Location
    14q32.33; chr14:106349283-106349720 (-)  GRCh38.p7

  • Human Ortholog
    IGHV4-30-4, immunoglobulin heavy variable 4-30-4
  • Synonyms
    IGHV4-3, IGHV4304
  • Links
    NCBI Gene ID: 28397
    UniProt: P0DP06

  • Chr Location
    14q32.33

  • Human Ortholog
    IGHV4-31, immunoglobulin heavy variable 4-31
  • Synonyms
    IGHV431
  • Links
    NCBI Gene ID: 28396
    UniProt: P0DP07

  • Chr Location
    14q32.33

  • Human Ortholog
    IGHV4-34, immunoglobulin heavy variable 4-34
  • Synonyms
    IGHV434, VH
  • Links
    NCBI Gene ID: 28395
    UniProt: P06331

  • Chr Location
    14q32.33; chr14:106373661-106374093 (-)  GRCh38.p7

  • Human Ortholog
    IGHV4-38-2, immunoglobulin heavy variable 4-38-2
  • Synonyms
    IGHV4B, IGHV4-B
  • Links
    NCBI Gene ID: 28389
    UniProt: P0DP08

  • Chr Location
    14q32.33

  • Human Ortholog
    IGHV4-39, immunoglobulin heavy variable 4-39
  • Synonyms
    IGHV439, VH
  • Links
    NCBI Gene ID: 28394
    UniProt: P01824

  • Chr Location
    14q32.33; chr14:106421709-106422147 (-)  GRCh38.p7

  • Human Ortholog
    IGHV4-4, immunoglobulin heavy variable 4-4
  • Synonyms
    IGHV44, VH
  • Links
    NCBI Gene ID: 28401
    UniProt: A0A075B6R2

  • Chr Location
    14q32.33; chr14:106011922-106012356 (-)  GRCh38.p7

  • Human Ortholog
    IGHV4-59, immunoglobulin heavy variable 4-59
  • Synonyms
    IGHV459, VH
  • Links
    NCBI Gene ID: 28392
    UniProt: P01825

  • Chr Location
    14q32.33; chr14:106627249-106627680 (-)  GRCh38.p7

  • Human Ortholog
    IGHV4-61, immunoglobulin heavy variable 4-61
  • Synonyms
    IGHV461, VH
  • Links
    NCBI Gene ID: 28391
    UniProt: A0A0C4DH41

  • Chr Location
    14q32.33; chr14:106639119-106639556 (-)  GRCh38.p7

  • Human Ortholog
    IGHV4OR15-8, immunoglobulin heavy variable 4/OR15-8 (non-functional)
  • Synonyms
    IGHV4OR158, VSIG6
  • Links
    NCBI Gene ID: 28317

  • Chr Location
    15q11.2

Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
Sequences &
Gene Models
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  • All Sequences
  • RefSeq
  • UniProt
Representative SequencesLengthStrain/SpeciesFlank
genomic 633457 NCBI Gene Model | MGI Sequence Detail 299 C57BL/6J ±  kb
transcript M61218 GenBank | ENA | DDBJ | MGI Sequence Detail 351 Not Specified  
polypeptide P18533 UniProt | EBI | MGI Sequence Detail 117 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • InterPro Domains
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR003599 Immunoglobulin subtype
    IPR013106 Immunoglobulin V-set domain
Molecular
Reagents
less

  • Microarray probesets 1
References
more
  • Summaries
    All 10
    Gene Ontology 1
  • Earliest
    J:2335 Press JL, et al., A new germline VH36-60 gene is used in the neonatal primary and adult memory response to (T,G)-A--L. Mol Immunol. 1991 Nov;28(11):1217-24
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
06/14/2022
MGI 6.19
The Jackson Laboratory