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Rpl10l Gene Detail
Summary
  • Symbol
    Rpl10l
  • Name
    ribosomal protein L10-like
  • Synonyms
    EG238217
  • Feature Type
    protein coding gene
  • IDs
    MGI:3647985
    NCBI Gene: 238217
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:66330153-66331175 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 12, 27.44 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    32 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3647985
protein coding gene Chr12:66330153-66331175 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019783
protein coding gene Chr12:65805734-65806739 (-)
A/J MGP_AJ_G0019741
protein coding gene Chr12:63388374-63389399 (-)
AKR/J MGP_AKRJ_G0019717
protein coding gene Chr12:65385270-65386292 (-)
BALB/cJ MGP_BALBcJ_G0025847
protein coding gene Chr2:76089833-76090828 (-)
C3H/HeJ MGP_C3HHeJ_G0019527
protein coding gene Chr12:65742336-65743361 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020173
protein coding gene Chr12:67900655-67901677 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017793
protein coding gene Chr12:61150089-61151114 (-)
CAST/EiJ MGP_CASTEiJ_G0019078
protein coding gene Chr12:60467936-60468961 (-)
CBA/J MGP_CBAJ_G0019496
protein coding gene Chr12:70360435-70361460 (-)
DBA/2J MGP_DBA2J_G0019612
protein coding gene Chr12:63308312-63309334 (-)
FVB/NJ MGP_FVBNJ_G0019600
protein coding gene Chr12:62292270-62293292 (-)
LP/J MGP_LPJ_G0019684
protein coding gene Chr12:65819817-65820839 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019638
protein coding gene Chr12:73354886-73355911 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020208
protein coding gene Chr12:64786764-64787786 (-)
PWK/PhJ MGP_PWKPhJ_G0018844
protein coding gene Chr12:57584342-57585367 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018639
protein coding gene Chr12:59151975-59152994 (-)
WSB/EiJ MGP_WSBEiJ_G0019129
protein coding gene Chr12:65319721-65320746 (-)



Homology
more
  • Human Ortholog
    RPL10L, ribosomal protein L10 like
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RPL10L, ribosomal protein L10 like
  • Synonyms
    RPL10_5_1358, SPGF63
  • Links
    NCBI Gene ID: 140801
    neXtProt AC: NX_Q96L21
    UniProt: Q96L21

  • Chr Location
    14q21.2; chr14:46651010-46651781 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with human RPL10L associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit male infertility associated with testicular hypoplasia, azoospermia,, arrest of male meiosis, male germ cell apoptosis, and impaired ribosome biogenesis in late prophase of meiosis I.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 238217 NCBI Gene Model | MGI Sequence Detail 1023 C57BL/6J ±  kb
    transcript NM_001162933 RefSeq | MGI Sequence Detail 1112 Not Specified  
    polypeptide P86048 UniProt | EBI | MGI Sequence Detail 214 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • PDB
    • InterPro Domains
      IPR047873 Large ribosomal subunit protein uL16
      IPR018255 Large ribosomal subunit protein uL16, conserved site, eukaryotes/archaea
      IPR016180 Large ribosomal subunit protein uL16 domain
      IPR001197 Large ribosomal subunit protein uL16, eukaryotes/archaea
      IPR036920 Large ribosomal subunit protein uL16 superfamily
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 5
      Primer pair 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 23
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 6
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:333015 Li H, et al., A male germ-cell-specific ribosome controls male fertility. Nature. 2022 Dec;612(7941):725-731

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory