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Spag11b Gene Detail
Summary
  • Symbol
    Spag11b
  • Name
    sperm associated antigen 11B
  • Feature Type
    protein coding gene
  • IDs
    MGI:3647173
    NCBI Gene: 546038
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:19190775-19193026 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 10.35 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    131 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3647173
 protein coding gene Chr8:19190775-19193026 (+)
129S1/SvImJ ENSMUSG00200032503
 protein coding gene Chr8:16002952-16005204 (+)
A/J ENSMUSG00195040950
 protein coding gene Chr8:16426026-16428278 (+)
AKR/J ENSMUSG00220032218
 protein coding gene Chr8:16188847-16191098 (+)
BALB/cJ ENSMUSG00180024596
 protein coding gene Chr8:16046384-16048636 (+)
C3H/HeJ ENSMUSG00175036571
 protein coding gene Chr8:16224449-16226701 (+)
C57BL/6NJ ENSMUSG00215022136
 protein coding gene Chr8:16160894-16163145 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030874
 protein coding gene Chr8:15336305-15338545 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210037568
 protein coding gene Chr8:16063276-16065528 (+)
DBA/2J ENSMUSG00185006239
 protein coding gene Chr8:16191088-16193340 (+)
FVB/NJ ENSMUSG00205017358
 protein coding gene Chr8:16072548-16074800 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230020816
 protein coding gene Chr8:18276386-18278638 (+)
NOD/ShiLtJ ENSMUSG00190031855
 protein coding gene Chr8:16195516-16197768 (+)
NZO/HlLtJ ENSMUSG00225042005
 protein coding gene Chr8:26124310-26126561 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    SPAG11A, sperm associated antigen 11A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPAG11A, sperm associated antigen 11A
  • Synonyms
    EDDM2A, HE2
  • Links
    NCBI Gene ID: 653423
    UniProt: Q6PDA7

  • Chr Location
    8p23.1
  • Human Ortholog
    SPAG11B, sperm associated antigen 11B
  • Synonyms
    EDDM2B, EP2, EP2C, EP2D, HE2, HE2C, SPAG11
  • Links
    NCBI Gene ID: 10407
    UniProt: Q08648

  • Chr Location
    8p23.1
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    2
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 546038 NCBI Gene Model | MGI Sequence Detail 2252 C57BL/6J ±  kb
transcript NM_001034905 RefSeq | MGI Sequence Detail 1740 C57BL/6  
polypeptide Q3UW43 UniProt | EBI | MGI Sequence Detail 113 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 4
    cDNA 4

    Microarray probesets 1
References
more
  • Summaries
    All 19
    Gene Ontology 2
    Phenotypes 3
  • Earliest
    J:101568 Patil AA, et al., Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract. Physiol Genomics. 2005 Sep 21;23(1):5-17
  • Latest
    J:332494 Dong X, et al., Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection. Immunity. 2022 Jul 15;55(9):1645-1662
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory