Tmem170b MGI Mouse Gene Detail - MGI:3647046

Symbol

Tmem170b
Name

transmembrane protein 170B
Synonyms

EG621976

Feature Type

protein coding gene
IDs

MGI:3647046
NCBI Gene: 621976
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr13:41759383-41794831 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 20.55 cM
Mapping Data

1 experiment

SNPs within 2kb

755 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3647046	protein coding gene	Chr13:41759358-41794831 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020490	protein coding gene	Chr13:40107754-40143541 (+)
A/J	MGP_AJ_G0020444	protein coding gene	Chr13:38770964-38806237 (+)
AKR/J	MGP_AKRJ_G0020422	protein coding gene	Chr13:39823776-39858891 (+)
BALB/cJ	MGP_BALBcJ_G0020440	protein coding gene	Chr13:38953748-38988844 (+)
C3H/HeJ	MGP_C3HHeJ_G0020239	protein coding gene	Chr13:39698115-39734004 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020873	protein coding gene	Chr13:41376690-41412969 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018460	protein coding gene	Chr13:36907578-36940105 (+)
CAST/EiJ	MGP_CASTEiJ_G0019754	protein coding gene	Chr13:39499364-39534744 (+)
CBA/J	MGP_CBAJ_G0020200	protein coding gene	Chr13:43144333-43181440 (+)
DBA/2J	MGP_DBA2J_G0020322	protein coding gene	Chr13:38337596-38374180 (+)
FVB/NJ	MGP_FVBNJ_G0020301	protein coding gene	Chr13:37842933-37878591 (+)
LP/J	MGP_LPJ_G0020397	protein coding gene	Chr13:40356187-40393572 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020330	protein coding gene	Chr13:43100248-43135305 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020916	protein coding gene	Chr13:39470820-39506567 (+)
PWK/PhJ	MGP_PWKPhJ_G0019509	protein coding gene	Chr13:38425697-38457549 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019339	protein coding gene	Chr13:38115999-38151345 (+)
WSB/EiJ	MGP_WSBEiJ_G0019816	protein coding gene	Chr13:39780830-39816924 (+)

Human Ortholog

TMEM170B, transmembrane protein 170B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMEM170B, transmembrane protein 170B
Links

HGNC:34244

NCBI Gene ID: 100113407

UniProt: Q5T4T1
Chr Location

chr6:11537749-11583524 (+) GRCh38

MGI Vertebrate Homology

Tmem170b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TMEM170B
Gene Tree

Tmem170b

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
Chemically induced (other)

1
Endonuclease-mediated

1
Genomic Mutations

1 involving Tmem170b
Find Mice (IMSR)

4 strains or lines available

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All GO Annotations

11
GO References

6

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

2

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmem170b

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All Sequences

32
RefSeq

4
UniProt

2
CCDS

CCDS49248.1, CCDS88445.1

Ensembl

ENSMUSG00000087370 (Evidence)
NCBI Gene

621976

			Length	Strain/Species	Flank
genomic	ENSMUSG00000087370	Ensembl Gene Model \| MGI Sequence Detail	35449	C57BL/6J	± kb
transcript	ENSMUST00000129449	Ensembl \| MGI Sequence Detail	7168	Not Applicable
polypeptide	ENSMUSP00000131144	Ensembl \| MGI Sequence Detail	132	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000031855 transmembrane protein 170B

(term hierarchy)
InterPro Domains

IPR019334 Transmembrane protein 170
GlyGen

P86050 1 site

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All nucleic 2

cDNA 2

Summaries

All 21

Gene Ontology 6

Phenotypes 6
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tmem170b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119412	Chr13:41759297-41759339 (+)	-65 bp
Tssr119413	Chr13:41759343-41759378 (+)	-22 bp
Tssr119414	Chr13:41759380-41759405 (+)	10 bp
Tssr119415	Chr13:41779440-41779468 (+)	20,071 bp
Tssr119416	Chr13:41790121-41790169 (+)	30,762 bp
Tssr119417	Chr13:41790872-41790875 (+)	31,491 bp
Tssr119418	Chr13:41793002-41793042 (+)	33,639 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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