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Spink14 Gene Detail
Summary
  • Symbol
    Spink14
  • Name
    serine peptidase inhibitor, Kazal type 14
  • Synonyms
    Gm5505
Location &
Maps
more
  • Sequence Map
    Chr18:44160936-44165275 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 23.74 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    305 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3646952
 protein coding gene Chr18:44160936-44165484 (+)
129S1/SvImJ ENSMUSG00200029649
 protein coding gene Chr18:41204317-41208646 (+)
A/J ENSMUSG00195024925
 protein coding gene Chr18:41365078-41369393 (+)
AKR/J ENSMUSG00220020421
 protein coding gene Chr18:41326690-41331004 (+)
BALB/cJ ENSMUSG00180007224
 protein coding gene Chr18:41819460-41823803 (+)
C3H/HeJ ENSMUSG00175010746
 protein coding gene Chr18:41338191-41342532 (+)
C57BL/6NJ ENSMUSG00215007544
 protein coding gene Chr18:41046433-41050772 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022238
 protein coding gene Chr18:41045238-41049650 (+)
CAST/EiJ ENSTCUG00005013038
 protein coding gene Chr18:40887774-40892117 (+)
CBA/J ENSMUSG00210022447
 protein coding gene Chr18:41385193-41389533 (+)
DBA/2J ENSMUSG00185027977
 protein coding gene Chr18:41293927-41298268 (+)
FVB/NJ ENSMUSG00205012396
 protein coding gene Chr18:40928456-40932785 (+)
JF1/MsJ ENSUMUG00000027690
 protein coding gene Chr18:41427911-41432250 (+)
LP/J ENSMUSG00230025462
 protein coding gene Chr18:43393971-43398300 (+)
NOD/ShiLtJ ENSMUSG00190027552
 protein coding gene Chr18:41052686-41057009 (+)
NZO/HlLtJ ENSMUSG00225026922
 protein coding gene Chr18:43261086-43265425 (+)
PWK/PhJ ENSLUMG00010020884
 protein coding gene Chr18:41520274-41524602 (+)
SPRET/EiJ ENSMSPG00010012148
 protein coding gene Chr18:41654100-41658126 (+)
WSB/EiJ ENSIUOG00005008783
 protein coding gene Chr18:41020186-41024513 (+)



Homology
more
  • Human Ortholog
    SPINK14, serine peptidase inhibitor Kazal type 14 (putative)
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPINK14, serine peptidase inhibitor Kazal type 14 (putative)
  • Synonyms
    SPINK5L2
  • Links
    NCBI Gene ID: 408187
    UniProt: Q6IE38

  • Chr Location
    chr5:148168546-148175619 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 433178 NCBI Gene Model | MGI Sequence Detail 4340 C57BL/6J ±  kb
    transcript NM_001039218 RefSeq | MGI Sequence Detail 566 C57BL/6  
    polypeptide NP_001034307 RefSeq | MGI Sequence Detail 96 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR002350 Kazal domain
      IPR036058 Kazal domain superfamily
      IPR050159 Kazal-type Serine Protease Inhibitor
    Molecular
    Reagents
    less
    • All nucleic 1
      cDNA 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 19
      Gene Ontology 2
      Phenotypes 5
    • Earliest
      J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory