Fignl2 MGI Mouse Gene Detail - MGI:3646919

Symbol

Fignl2
Name

fidgetin-like 2

Feature Type

protein coding gene
IDs

MGI:3646919
NCBI Gene: 668225
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr15:100948075-100976448 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 56.39 cM
Mapping Data

1 experiment

SNPs within 2kb

103 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3646919	protein coding gene	Chr15:100948075-100976465 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022363	protein coding gene	Chr15:103075115-103079328 (-)
A/J	MGP_AJ_G0022325	protein coding gene	Chr15:99014540-99018747 (-)
AKR/J	MGP_AKRJ_G0022301	protein coding gene	Chr15:102023456-102027661 (-)
BALB/cJ	MGP_BALBcJ_G0022329	protein coding gene	Chr15:99108550-99113025 (-)
C3H/HeJ	MGP_C3HHeJ_G0022099	protein coding gene	Chr15:102116390-102120593 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022777	protein coding gene	Chr15:106922596-106928403 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020302	protein coding gene	Chr15:94740243-94744457 (-)
CAST/EiJ	MGP_CASTEiJ_G0021624	protein coding gene	Chr15:102954291-102958509 (-)
CBA/J	MGP_CBAJ_G0022068	protein coding gene	Chr15:110609589-110613792 (-)
DBA/2J	MGP_DBA2J_G0022195	protein coding gene	Chr15:98342798-98347003 (-)
FVB/NJ	MGP_FVBNJ_G0022174	protein coding gene	Chr15:97386031-97390388 (-)
LP/J	MGP_LPJ_G0022266	protein coding gene	Chr15:103215731-103219938 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022195	protein coding gene	Chr15:114329268-114333473 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022791	protein coding gene	Chr15:102042171-102046377 (-)
PWK/PhJ	MGP_PWKPhJ_G0021363	protein coding gene	Chr15:98491350-98495587 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021195	protein coding gene	Chr15:101938488-101949342 (-)
WSB/EiJ	MGP_WSBEiJ_G0021674	protein coding gene	Chr15:102662065-102666271 (-)

Human Ortholog

FIGNL2, fidgetin like 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FIGNL2, fidgetin like 2
Links

HGNC:13287

NCBI Gene ID: 401720

neXtProt AC: NX_A6NMB9

UniProt: A6NMB9
Chr Location

12q13.13; chr12:51817899-51848718 (-) GRCh38

MGI Vertebrate Homology

Fignl2 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: FIGNL2
Gene Tree

Fignl2

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References

1 with disease annotations

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

1
Radiation induced

2
Targeted

1
Genomic Mutations

3 involving Fignl2
Incidental Mutations

APF
Find Mice (IMSR)

11 strains or lines available

Conditional knock-out in cultured adult dorsal root ganglion neurons results in longer axons and attenuated growth cone retraction in response to inhibitory molecules.

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All GO Annotations

5
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

3

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

GEISHA FIGNL2

Xenbase fignl2

ZFIN fignl2

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All Sequences

36
RefSeq

6
UniProt

1
CCDS

CCDS57012.1

Ensembl

ENSMUSG00000095440 (Evidence)
NCBI Gene

668225

			Length	Strain/Species	Flank
genomic	ENSMUSG00000095440	Ensembl Gene Model \| MGI Sequence Detail	28374	C57BL/6J	± kb
transcript	ENSMUST00000178140	Ensembl \| MGI Sequence Detail	4206	Not Applicable
polypeptide	ENSMUSP00000137256	Ensembl \| MGI Sequence Detail	644	Not Applicable

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UniProt

1 Sequence
InterPro Domains

IPR003593 AAA+ ATPase domain

IPR003959 ATPase, AAA-type, core

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 3

cDNA 3

Microarray probesets 1

Summaries

All 33

Diseases 1

Gene Ontology 2

Phenotypes 21
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:309596 Baker L, et al., Fidgetin-like 2 negatively regulates axonal growth and can be targeted to promote functional nerve regeneration. JCI Insight. 2021 May 10;6(9)

TSS for Fignl2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr136518	Chr15:100976763-100976813 (-)	-340 bp
Tssr136517	Chr15:100976688-100976711 (-)	-252 bp
Tssr136516	Chr15:100976370-100976394 (-)	66 bp
Tssr136515	Chr15:100976291-100976300 (-)	152 bp
Tssr136514	Chr15:100976250-100976261 (-)	192 bp
Tssr136513	Chr15:100952206-100952225 (-)	24,232 bp
Tssr136512	Chr15:100950132-100950145 (-)	26,309 bp
Tssr136511	Chr15:100950059-100950087 (-)	26,375 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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