Amt
Gene Detail

Symbol Name ID

Amt aminomethyltransferase MGI:3646700

Synonyms

EG434437

Feature Type

protein coding gene

Genetic Map

Chromosome 9

59.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr9:108296853-108301571 bp, + strand From VEGA annotation of GRCm38   4719 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:409  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: aminomethyltransferase
Gene Tree: Amt

Human homologs

Human Homolog		AMT, aminomethyltransferase
NCBI Gene ID		275
neXtProt AC		NX_P48728
Human Synonyms		GCE, GCST, GCVT, NKH
Human Chr (Location)		3p21.2-p21.1; chr3:49454211-49460111 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human AMT

Alleles and phenotypes

All alleles(20) : Targeted(2) Gene trapped(18)

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	glycine catabolic process, methylation
Component	cytoplasm, mitochondrion
Function	aminomethyltransferase activity, methyltransferase activity, ...

Expression

Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)   
Theiler Stages: 22

Assay Type	Results
RNA in situ	94

cDNA source data(4)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(5) cDNA(4) Primer pair(1)
Microarray probesets(1)

Other database links

VEGA Gene Model	OTTMUSG00000032968 (Evidence)
Ensembl Gene Model	ENSMUSG00000032607 (Evidence)
Entrez Gene	434437 (Evidence)
UniGene	390225
DFCI	TC1591644
DoTS	DT.110611599
NIA Mouse Gene Index	U043028
EC	2.1.2.10
Consensus CDS Project	CCDS23519.1
International Mouse Knockout Project Status	Amt

Sequences

Length	Strain/Species
genomic	OTTMUSG00000032968	VEGA Gene Model | MGI Sequence Detail	4719	C57BL/6J
transcript	OTTMUST00000082195	VEGA | MGI Sequence Detail	1315	Not Applicable
polypeptide	OTTMUSP00000044035	VEGA | MGI Sequence Detail	403	Not Applicable

All sequences(23) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(20 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006223	Glycine cleavage system T protein
InterPro	IPR013977	Glycine cleavage T-protein, C-terminal barrel
InterPro	IPR006222	Glycine cleavage T-protein, N-terminal
InterPro	IPR027266	GTP-binding protein TrmE/Glycine cleavage system T protein, domain 1
Protein Ontology	PR:000004005	aminomethyltransferase, mitochondrial

References

(Earliest) J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
(Latest) J:181568 Narisawa A, et al., Mutations in genes encoding the glycine cleavage system predispose to neural tube defects in mice and humans. Hum Mol Genet. 2012 Apr 1;21(7):1496-503
All references(29)