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Amt
Gene Detail
 Symbol
Name
ID
Amt
aminomethyltransferase
MGI:3646700
Synonyms EG434437
Feature Type protein coding gene
Genetic Map
Chromosome 9
59.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:108296853-108301571 bp, + strand
From VEGA annotation of GRCm38

  4719 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:409  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: aminomethyltransferase
Gene Tree: Amt

Human
homologs
Human Homolog AMT, aminomethyltransferase
NCBI Gene ID 275
neXtProt AC  NX_P48728
Human Synonyms  GCE, GCST, GCVT, NKH
Human Chr (Location)  3p21.2-p21.1; chr3:49416778-49422678 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human AMT
Alleles
and
phenotypes
All alleles(20) : Gene trapped(18) Targeted(2)
 
Mice homozygous for a gene trapped allele develop neural tubes defects at high frequency and exhibit prenatal lethality.
 
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process glycine catabolic process, methylation
Component cytoplasm, mitochondrion
Function aminomethyltransferase activity, methyltransferase activity, ...
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)   
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(4)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(5) cDNA(4) Primer pair(1)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000032968 (Evidence)
Ensembl Gene ModelENSMUSG00000032607 (Evidence)
Entrez Gene434437 (Evidence)
UniGene390225
DFCITC1591644
DoTSDT.110611599
NIA Mouse Gene IndexU043028
EC2.1.2.10
Consensus CDS ProjectCCDS23519.1
International Mouse Knockout Project StatusAmt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032968 VEGA Gene Model | MGI Sequence Detail 4719 C57BL/6J ±  kb
transcript OTTMUST00000082195 VEGA | MGI Sequence Detail 1315 Not Applicable 
polypeptide OTTMUSP00000044035 VEGA | MGI Sequence Detail 403 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(22 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006223 Glycine cleavage system T protein
InterPro IPR013977 Glycine cleavage T-protein, C-terminal barrel
InterPro IPR006222 Glycine cleavage T-protein, N-terminal
InterPro IPR027266 GTP-binding protein TrmE/Glycine cleavage system T protein, domain 1
Protein Ontology PR:000004005 aminomethyltransferase, mitochondrial
References (Earliest) J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
(Latest) J:181568 Narisawa A, et al., Mutations in genes encoding the glycine cleavage system predispose to neural tube defects in mice and humans. Hum Mol Genet. 2012 Apr 1;21(7):1496-503
All references(29)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory