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Amt
Gene Detail
Symbol

Name
ID
Amt
aminomethyltransferase
MGI:3646700
Synonyms
EG434437
Feature Type
protein coding gene
Genetic Map
Chromosome 9
59.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:108296853-108302302 bp, + strand
From VEGA annotation of GRCm38

  5450 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:409  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: AMT
Protein SuperFamily: aminomethyltransferase
Gene Tree: Amt

Human
homologs
AMT, aminomethyltransferase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 275
neXtProt AC: NX_P48728

Human Synonyms: GCE, GCST, GCVT, NKH

Human Chr (Location): 3p21.31; chr3:49416778-49422678 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human AMT

Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Gene trapped(18) Targeted(2)
Incidental mutations (data from CvDC )
 
Mice homozygous for a gene trapped allele develop neural tubes defects at high frequency and exhibit prenatal lethality.
 
Interactions
Amt interacts with 10 markers (Mir137, Mir215, Mir384, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process glycine catabolic process
Component mitochondrion
Function aminomethyltransferase activity, transaminase activity, ...
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(4)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase amt ; ZFIN amt    NEW 
Molecular
reagents
All nucleic(5) cDNA(4) Primer pair(1)
Microarray probesets(1)
Other database
links
VEGA Gene Model OTTMUSG00000032968 (Evidence)
Ensembl Gene Model ENSMUSG00000032607 (Evidence)
Entrez Gene 434437 (Evidence)
UniGene 390225
DFCI TC1591644
DoTS DT.110611599
NIA Mouse Gene Index U043028
EC 2.1.2.10
Consensus CDS Project CCDS23519.1
International Mouse Phenotyping Consortium Status Amt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032968 VEGA Gene Model | MGI Sequence Detail 5450 C57BL/6J ±  kb
transcript OTTMUST00000082195 VEGA | MGI Sequence Detail 2082 Not Applicable 
polypeptide OTTMUSP00000044035 VEGA | MGI Sequence Detail 403 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(24 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR028896 Aminomethyltransferase/Dimethylsulfonioproprionate demethylase DmdA
InterPro IPR006223 Glycine cleavage system T protein
InterPro IPR013977 Glycine cleavage T-protein, C-terminal barrel domain
InterPro IPR006222 Glycine cleavage T-protein-like, N-terminal
InterPro IPR029043 Glycine cleavage T-protein/YgfZ, C-terminal domain
InterPro IPR027266 GTP-binding protein TrmE/Glycine cleavage system T protein, domain 1
Protein Ontology PR:000004005 aminomethyltransferase, mitochondrial
References
(Earliest) J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
(Latest) J:181568 Narisawa A, et al., Mutations in genes encoding the glycine cleavage system predispose to neural tube defects in mice and humans. Hum Mol Genet. 2012 Apr 1;21(7):1496-503
All references(28)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory