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Siglec15 Gene Detail
Summary
  • Symbol
    Siglec15
  • Name
    sialic acid binding Ig-like lectin 15
  • Synonyms
    Cd33l3, EG620235
  • Feature Type
    protein coding gene
  • IDs
    MGI:3646642
    NCBI Gene: 620235
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:78043614-78057395 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 52.43 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    68 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3646642
protein coding gene Chr18:78042499-78057437 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024582
protein coding gene Chr18:78840769-78856082 (-)
A/J MGP_AJ_G0024549
protein coding gene Chr18:75385687-75399463 (-)
AKR/J MGP_AKRJ_G0024520
protein coding gene Chr18:77606082-77619853 (-)
BALB/cJ MGP_BALBcJ_G0024548
protein coding gene Chr18:75576399-75590842 (-)
C3H/HeJ MGP_C3HHeJ_G0024317
protein coding gene Chr18:77711832-77725599 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024995
protein coding gene Chr18:80894089-80907842 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022425
protein coding gene Chr18:74336853-74350639 (-)
CAST/EiJ MGP_CASTEiJ_G0023789
protein coding gene Chr18:78035999-78053202 (-)
CBA/J MGP_CBAJ_G0024286
protein coding gene Chr18:83795688-83809446 (-)
DBA/2J MGP_DBA2J_G0024416
protein coding gene Chr18:74926984-74940739 (-)
FVB/NJ MGP_FVBNJ_G0024382
protein coding gene Chr18:74284752-74301961 (-)
LP/J MGP_LPJ_G0024500
protein coding gene Chr18:78730462-78744114 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024412
protein coding gene Chr18:85007035-85021166 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025043
protein coding gene Chr18:77786362-77800154 (-)
PWK/PhJ MGP_PWKPhJ_G0023534
protein coding gene Chr18:75360412-75374610 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023338
protein coding gene Chr18:77964826-77978625 (-)
WSB/EiJ MGP_WSBEiJ_G0023853
protein coding gene Chr18:77735316-77749039 (-)



Homology
more
  • Human Ortholog
    SIGLEC15, sialic acid binding Ig like lectin 15
  • Vertebrate Orthologs
    11
  • Human Ortholog
    SIGLEC15, sialic acid binding Ig like lectin 15
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD33L3, HsT1361, SIGLEC-15
  • Links
    NCBI Gene ID: 284266
    neXtProt AC: NX_Q6ZMC9
    UniProt: Q6ZMC9

  • Chr Location
    18q12.3; chr18:45825580-45842556 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele exhibit impaired osteoclast differentiation and function and mild osteopetrosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000091055 Ensembl Gene Model | MGI Sequence Detail 13782 C57BL/6J ±  kb
transcript ENSMUST00000170760 Ensembl | MGI Sequence Detail 1156 Not Applicable  
polypeptide ENSMUSP00000126901 Ensembl | MGI Sequence Detail 342 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
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  • All nucleic 5
    cDNA 5

    Microarray probesets 1
References
more
  • Summaries
    All 15
    Gene Ontology 1
    Phenotypes 4
  • Earliest
    J:193006 Ishida-Kitagawa N, et al., Siglec-15 protein regulates formation of functional osteoclasts in concert with DNAX-activating protein of 12 kDa (DAP12). J Biol Chem. 2012 May 18;287(21):17493-502
  • Latest
    J:228154 Shimizu T, et al., Sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) mediates periarticular bone loss, but not joint destruction, in murine antigen-induced arthritis. Bone. 2015 Oct;79:65-70

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory