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Clrn2 Gene Detail
Summary
  • Symbol
    Clrn2
  • Name
    clarin 2
  • Synonyms
    EG624224, mpc169H
  • Feature Type
    protein coding gene
  • IDs
    MGI:3646230
    NCBI Gene: 624224
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr5:45453751-45464149 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, Syntenic
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    87 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3646230
protein coding gene Chr5:45453751-45464149 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029532
protein coding gene Chr5:44156586-44166968 (+)
A/J MGP_AJ_G0029500
protein coding gene Chr5:42622221-42632603 (+)
AKR/J MGP_AKRJ_G0029448
protein coding gene Chr5:44111051-44122009 (+)
BALB/cJ MGP_BALBcJ_G0029509
protein coding gene Chr5:43094898-43105264 (+)
C3H/HeJ MGP_C3HHeJ_G0029232
protein coding gene Chr5:44116170-44127600 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029963
protein coding gene Chr5:46246974-46257479 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027202
protein coding gene Chr5:39792156-39802246 (+)
CAST/EiJ MGP_CASTEiJ_G0028640
protein coding gene Chr5:43260609-43271168 (+)
CBA/J MGP_CBAJ_G0029201
protein coding gene Chr5:47509549-47524584 (+)
DBA/2J MGP_DBA2J_G0029347
protein coding gene Chr5:42709723-42720319 (+)
FVB/NJ MGP_FVBNJ_G0029307
protein coding gene Chr5:42137834-42148800 (+)
LP/J MGP_LPJ_G0029432
protein coding gene Chr5:44640991-44651375 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029335
protein coding gene Chr5:48244263-48255483 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029996
protein coding gene Chr5:43630274-43640653 (+)
PWK/PhJ MGP_PWKPhJ_G0028364
protein coding gene Chr5:41835230-41845805 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028198
protein coding gene Chr5:43070134-43081424 (+)
WSB/EiJ MGP_WSBEiJ_G0028721
protein coding gene Chr5:43689893-43700305 (+)



Homology
more
  • Human Ortholog
    CLRN2, clarin 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CLRN2, clarin 2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 645104
    neXtProt AC: NX_A0PK11
    UniProt: A0PK11

  • Chr Location
    4p15.32; chr4:17515165-17527104 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 84057
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CLRN2
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 3 alleles in 4 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele exhibit nonsyndromic progressive hearing loss with a lack of fast-graded voltage responses.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 624224 NCBI Gene Model | MGI Sequence Detail 10399 C57BL/6J ±  kb
    transcript NM_001163317 RefSeq | MGI Sequence Detail 944 Not Specified  
    polypeptide NP_001156789 RefSeq | MGI Sequence Detail 232 Not Specified  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR026748 Clarin
    Molecular
    Reagents
    less
    • All nucleic 3
      cDNA 3

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:5792195
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 1
      Diseases 1
      Phenotypes 23
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:283627 Dunbar LA, et al., Clarin-2 is essential for hearing by maintaining stereocilia integrity and function. EMBO Mol Med. 2019 Sep;11(9):e10288

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    11/10/2020
    MGI 6.16
    The Jackson Laboratory