Skor2
Gene Detail

Symbol Name ID

Skor2 SKI family transcriptional corepressor 2 MGI:3645984

Synonyms

Corl2, Fussel18, Gm7348

Feature Type

protein coding gene

Genetic Map

Chromosome 18

51.93 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr18:76856405-76900342 bp, + strand From NCBI annotation of GRCm38   43938 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:64797  Vertebrate Homology Class
1 human; 1 mouse; 1 rhesus macaque; 1 chicken

Gene Tree: Skor2

Human homologs

Human Homolog		SKOR2, SKI family transcriptional corepressor 2
NCBI Gene ID		652991
Human Synonyms		CORL2, FUSSEL18
Human Chr (Location)		18q21.1; chr18:44738460-44775554 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Gene trapped(1) Transposon induced(3)
 

Mice homozygous for a transposon insertion results in increased postnatal lethality, cleft palate, respiratory failure, small size, abnormal cerebellum development, and abnormal Purkinje cell differentiation.

 

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	cerebellar Purkinje cell differentiation, cerebellum morphogenesis, ...
Component	cytoplasm, nucleus
Function	histone deacetylase binding, nucleotide binding, ...

This is a GO Consortium Reference Genome Project gene.

Expression

Literature Summary: (7 records)
Data Summary: Results (88)    Tissues (39)    Images (36)
Theiler Stages: 18, 19, 20, 21, 23, 25, 28

Assay Type	Results
Immunohistochemistry	26
RNA in situ	52
RT-PCR	10

cDNA source data(2)
External Resources: GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(6) cDNA(3) Primer pair(3)
Microarray probesets(1)

Other database links

Ensembl Gene Model	ENSMUSG00000091519 (Evidence)
Entrez Gene	664805 (Evidence)
UniGene	329543
NIA Mouse Gene Index	U107320
Consensus CDS Project	CCDS50322.1
International Mouse Knockout Project Status	Skor2

Sequences

Length	Strain/Species
genomic	664805	NCBI Gene Model | MGI Sequence Detail	43938	C57BL/6J
transcript	NM_001109743	RefSeq | MGI Sequence Detail	3141	Not Specified
polypeptide	A7M7C7	UniProt | EBI | MGI Sequence Detail	1008	Not Applicable

All sequences(10) RefSeq(3) UniProt(1)

Polymorphisms

SNPs(69 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR014890	c-SKI SMAD4-binding domain
InterPro	IPR009061	DNA binding domain, putative
InterPro	IPR010919	SAND domain-like
InterPro	IPR023216	Transcription regulator SKI/SnoN
InterPro	IPR003380	Transforming protein Ski
Protein Ontology	PR:000005759	ladybird homeobox corepressor 1-like protein

Graphical View of Protein Domain Structure

References

(Earliest) J:102645 Arndt S, et al., Cloning and functional characterization of a new Ski homolog, Fussel-18, specifically expressed in neuronal tissues. Lab Invest. 2005 Nov;85(11):1330-41
(Latest) J:184000 Baubet V, et al., Rp58 is essential for the growth and patterning of the cerebellum and for glutamatergic and GABAergic neuron development. Development. 2012 Jun;139(11):1903-9
All references(25)

Other accession IDs

MGI:3619262