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Skor2 Gene Detail
Summary
  • Symbol
    Skor2
  • Name
    SKI family transcriptional corepressor 2
  • Synonyms
    Corl2, Fussel18, Gm7348
  • Feature Type
    protein coding gene
  • IDs
    MGI:3645984
    NCBI Gene: 664805
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr18:76856405-76900342 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      43938 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 51.93 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    SKOR2, SKI family transcriptional corepressor 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SKOR2, SKI family transcriptional corepressor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CH18515, CORL2, FUSSEL18
  • Links
    NCBI Gene ID: 652991
    neXtProt AC: NX_Q2VWA4
    UniProt: Q2VWA4

  • Chr Location
    18q21.1; chr18:47206182-47249524 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 4 alleles in 2 genetic backgrounds
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for null mutations display neonatal and postnatal lethality, abnormal cerebellum development, and abnormal Purkinje cell differentiation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000091519 Ensembl Gene Model | MGI Sequence Detail 43938 C57BL/6J ±  kb
    transcript ENSMUST00000166956 Ensembl | MGI Sequence Detail 3141 Not Applicable  
    polypeptide ENSMUSP00000132338 Ensembl | MGI Sequence Detail 1008 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      301 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 3
      Primer pair 3

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:3619262
    References
    more
    • Summaries
      All 28
      Developmental Gene Expression 11
      Gene Ontology 6
      Phenotypes 5
    • Earliest
      J:102645 Arndt S, et al., Cloning and functional characterization of a new Ski homolog, Fussel-18, specifically expressed in neuronal tissues. Lab Invest. 2005 Nov;85(11):1330-41
    • Latest
      J:251975 Vibulyaseck S, et al., Spatial rearrangement of Purkinje cell subsets forms the transverse and longitudinal compartmentalization in the mouse embryonic cerebellum. J Comp Neurol. 2017 Oct 1;525(14):2971-2990

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory