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Skor2 Gene Detail
Summary
  • Symbol
    Skor2
  • Name
    SKI family transcriptional corepressor 2
  • Synonyms
    Corl2, Fussel18, Gm7348
  • Feature Type
    protein coding gene
  • IDs
    MGI:3645984
    NCBI Gene: 664805
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:76944100-76988037 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 51.93 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    264 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3645984
 protein coding gene Chr18:76934428-76988759 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024568
 protein coding gene Chr18:77576553-77623106 (+)
A/J MGP_AJ_G0024535
 protein coding gene Chr18:74179532-74226736 (+)
AKR/J MGP_AKRJ_G0024506
 protein coding gene Chr18:76387224-76431183 (+)
BALB/cJ no annotation
C3H/HeJ MGP_C3HHeJ_G0024303
 protein coding gene Chr18:76495804-76539866 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024981
 protein coding gene Chr18:79622852-79671965 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022411
 protein coding gene Chr18:73219365-73263440 (+)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0024272
 protein coding gene Chr18:82416860-82463300 (+)
DBA/2J MGP_DBA2J_G0024402
 protein coding gene Chr18:73772908-73816754 (+)
FVB/NJ MGP_FVBNJ_G0024368
 protein coding gene Chr18:73127744-73172466 (+)
LP/J MGP_LPJ_G0024486
 protein coding gene Chr18:77457676-77503432 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024398
 protein coding gene Chr18:83702274-83753656 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025029
 protein coding gene Chr18:76534803-76578639 (+)
PWK/PhJ MGP_PWKPhJ_G0023520
 protein coding gene Chr18:74175682-74220327 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023324
 protein coding gene Chr18:76730837-76776660 (+)
WSB/EiJ MGP_WSBEiJ_G0023839
 protein coding gene Chr18:76500343-76547211 (+)



Homology
more
  • Human Ortholog
    SKOR2, SKI family transcriptional corepressor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SKOR2, SKI family transcriptional corepressor 2
  • Synonyms
    CH18515, CORL2, FUSSEL18
  • Links
    NCBI Gene ID: 652991
    neXtProt AC: NX_Q2VWA4
    UniProt: Q2VWA4

  • Chr Location
    18q21.1; chr18:47206169-47251660 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for null mutations display neonatal and postnatal lethality, abnormal cerebellum development, and abnormal Purkinje cell differentiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    834
  • Tissues
    50
  • cDNA Data
    3
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000091519 Ensembl Gene Model | MGI Sequence Detail 43938 C57BL/6J ±  kb
    transcript ENSMUST00000166956 Ensembl | MGI Sequence Detail 3141 Not Applicable  
    polypeptide ENSMUSP00000132338 Ensembl | MGI Sequence Detail 1008 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 5
      Primer pair 5

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:3619262
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 17
      Gene Ontology 5
      Phenotypes 6
    • Earliest
      J:102645 Arndt S, et al., Cloning and functional characterization of a new Ski homolog, Fussel-18, specifically expressed in neuronal tissues. Lab Invest. 2005 Nov;85(11):1330-41
    • Latest
      J:343072 Vermeiren S, et al., Prdm12 represses the expression of the visceral neuron determinants Phox2a/b in developing somatosensory ganglia. iScience. 2023 Dec 15;26(12):108364
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory