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Skor2
Gene Detail
 Symbol
Name
ID
Skor2
SKI family transcriptional corepressor 2
MGI:3645984
Synonyms Corl2, Fussel18, Gm7348
Feature Type protein coding gene
Genetic Map
Chromosome 18
51.93 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr18:76856405-76900342 bp, + strand
From NCBI annotation of GRCm38

  43938 bp   ±  kb flank

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Mouse Genome Browser
Vertebrate
homology
HomoloGene:64797  Vertebrate Homology Class
1 human; 1 mouse; 1 rhesus macaque; 1 chicken

Gene Tree: Skor2

Human
homologs
Human Homolog SKOR2, SKI family transcriptional corepressor 2
NCBI Gene ID 652991
neXtProt AC  NX_Q2VWA4
Human Synonyms  CORL2, FUSSEL18
Human Chr (Location)  18q21.1; chr18:47206694-47249183 (-)  GRCh38
Alleles
and
phenotypes
All alleles(4) : Gene trapped(1) Transposon induced(3)
 
Mice homozygous for a transposon insertion results in increased postnatal lethality, cleft palate, respiratory failure, small size, abnormal cerebellum development, and abnormal Purkinje cell differentiation.
 
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cerebellar Purkinje cell differentiation, cerebellum morphogenesis, ...
Component cytoplasm, nucleus
Function histone deacetylase binding, SMAD binding, ...
This is a GO Consortium Reference Genome Project gene.
Expression
Literature Summary: (7 records)
Data Summary: Results (88)    Tissues (39)    Images (36)
Theiler Stages: 18, 19, 20, 21, 23, 25, 28
Assay TypeResults
Immunohistochemistry 26
RNA in situ 52
RT-PCR 10
cDNA source data(2)
External Resources: GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(6) cDNA(3) Primer pair(3)
Microarray probesets(1)
Other database
links
Ensembl Gene ModelENSMUSG00000091519 (Evidence)
Entrez Gene664805 (Evidence)
UniGene329543
NIA Mouse Gene IndexU107320
Consensus CDS ProjectCCDS50322.1
International Mouse Knockout Project StatusSkor2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 664805 NCBI Gene Model | MGI Sequence Detail 43938 C57BL/6J ±  kb
transcript NM_001109743 RefSeq | MGI Sequence Detail 3141 Not Specified 
polypeptide A7M7C7 UniProt | EBI | MGI Sequence Detail 1008 Not Applicable 

For the selected sequences
All sequences(12) RefSeq(5) UniProt(1)
Polymorphisms SNPs within 2kb(271 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014890 c-SKI SMAD4-binding domain
InterPro IPR009061 DNA binding domain, putative
InterPro IPR010919 SAND domain-like
InterPro IPR023216 Transcription regulator SKI/SnoN
InterPro IPR003380 Transforming protein Ski
Protein Ontology PR:000005759 ladybird homeobox corepressor 1-like protein
Graphical View of Protein Domain Structure
References (Earliest) J:102645 Arndt S, et al., Cloning and functional characterization of a new Ski homolog, Fussel-18, specifically expressed in neuronal tissues. Lab Invest. 2005 Nov;85(11):1330-41
(Latest) J:184000 Baubet V, et al., Rp58 is essential for the growth and patterning of the cerebellum and for glutamatergic and GABAergic neuron development. Development. 2012 Jun;139(11):1903-9
All references(24)
Other
accession IDs
MGI:3619262

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory