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Rgs21 Gene Detail
Summary
  • Symbol
    Rgs21
  • Name
    regulator of G-protein signalling 21
  • Synonyms
    EG624910
  • Feature Type
    protein coding gene
  • IDs
    MGI:3645243
    NCBI Gene: 624910
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr1:144519690-144567667 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 62.66 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    256 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3645243
protein coding gene Chr1:144516648-144567667 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016568
protein coding gene Chr1:148889195-148946559 (-)
A/J MGP_AJ_G0016551
protein coding gene Chr1:142934040-142986653 (-)
AKR/J MGP_AKRJ_G0016516
protein coding gene Chr1:147335665-147386580 (-)
BALB/cJ MGP_BALBcJ_G0016511
protein coding gene Chr1:143374818-143425879 (-)
C3H/HeJ MGP_C3HHeJ_G0016336
protein coding gene Chr1:147447487-147499341 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016972
protein coding gene Chr1:153898553-153957368 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014681
protein coding gene Chr1:135711938-135763327 (-)
CAST/EiJ MGP_CASTEiJ_G0015915
protein coding gene Chr1:146852126-146906020 (-)
CBA/J MGP_CBAJ_G0016310
protein coding gene Chr1:159366053-159421563 (-)
DBA/2J MGP_DBA2J_G0016416
protein coding gene Chr1:142042894-142094413 (-)
FVB/NJ MGP_FVBNJ_G0016414
protein coding gene Chr1:140505372-140559067 (-)
LP/J MGP_LPJ_G0016487
protein coding gene Chr1:149895954-149949513 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016440
protein coding gene Chr1:165802140-165876709 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017008
protein coding gene Chr1:147068124-147121599 (-)
PWK/PhJ MGP_PWKPhJ_G0015701
protein coding gene Chr1:140929214-140984821 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015488
protein coding gene Chr1:145851625-145901388 (-)
WSB/EiJ MGP_WSBEiJ_G0015978
protein coding gene Chr1:147110154-147166657 (-)



Homology
more
  • Human Ortholog
    RGS21, regulator of G protein signaling 21
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RGS21, regulator of G protein signaling 21
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 431704
    neXtProt AC: NX_Q2M5E4
    UniProt: Q2M5E4

  • Chr Location
    1q31.2; chr1:192316992-192367285 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 82452
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RGS21
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    2
  • Gene trapped
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Rgs21
  • Find Mice (IMSR)
Mice show reduced aversion to bitter taste and reduced preference towards sweeteners, umami taste, and salty taste.
Expression
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 624910 NCBI Gene Model | MGI Sequence Detail 47978 C57BL/6J ±  kb
transcript NM_001290269 RefSeq | MGI Sequence Detail 827 C57BL/6  
polypeptide NP_001277198 RefSeq | MGI Sequence Detail 152 C57BL/6  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less

  • Microarray probesets 1
References
more
  • Summaries
    All 14
    Phenotypes 5
  • Earliest
    J:142754 Hansen GM, et al., Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Genome Res. 2008 Oct;18(10):1670-9
  • Latest
    J:278472 Schroer AB, et al., Development of Full Sweet, Umami, and Bitter Taste Responsiveness Requires Regulator of G protein Signaling-21 (RGS21). Chem Senses. 2018 May 23;43(5):367-378

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/01/2019
MGI 6.14
The Jackson Laboratory