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Lipt1 Gene Detail
Summary
  • Symbol
    Lipt1
  • Name
    lipoyltransferase 1
  • Synonyms
    EG623661
  • Feature Type
    protein coding gene
  • IDs
    MGI:3645211
    NCBI Gene: 623661
Location & Maps
more
  • Sequence Map
    Chr1:37871738-37876228 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4491 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 16.13 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    LIPT1, lipoyltransferase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LIPT1, lipoyltransferase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LIPT1D
  • Links
    NCBI Gene ID: 51601
    neXtProt AC: NX_Q9Y234

  • Chr Location
    2q11.2; chr2:99154955-99163157 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 50569
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LIPT1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human LIPT1 associations

Human Disease Mouse Models
       Lipoyltransferase 1 Deficiency; LIPT1D   OMIM: 616299
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Targeted
    3
  • Genomic Mutations
    1 involving Lipt1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022093 VEGA Gene Model | MGI Sequence Detail 4491 C57BL/6J ±  kb
transcript OTTMUST00000052446 VEGA | MGI Sequence Detail 1485 Not Applicable  
polypeptide OTTMUSP00000024871 VEGA | MGI Sequence Detail 373 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    53 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000009842 lipoyltransferase 1, mitochondrial
  • EC
  • InterPro Domains
    IPR004143 Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL), catalytic domain
    IPR004562 Lipoyltransferase/lipoate-protein ligase
Molecular
Reagents
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  • All nucleic 13
    cDNA 13

    Microarray probesets 3
References
more
  • Summaries
    All 25
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory