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Spink7 Gene Detail
Summary
  • Symbol
    Spink7
  • Name
    serine peptidase inhibitor, Kazal type 7 (putative)
  • Synonyms
    EG408198
  • Feature Type
    protein coding gene
  • IDs
    MGI:3644691
    NCBI Gene: 408198
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:62725265-62729398 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 35.33 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    69 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3644691
 protein coding gene Chr18:62725254-62729639 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024492
 protein coding gene Chr18:62535892-62539743 (-)
A/J MGP_AJ_G0024459
 protein coding gene Chr18:59853894-59857738 (-)
AKR/J MGP_AKRJ_G0024429
 protein coding gene Chr18:61512046-61515893 (-)
BALB/cJ MGP_BALBcJ_G0024458
 protein coding gene Chr18:59987618-59991462 (-)
C3H/HeJ MGP_C3HHeJ_G0024226
 protein coding gene Chr18:61749292-61753228 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024905
 protein coding gene Chr18:64223667-64227518 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022336
 protein coding gene Chr18:59384313-59388258 (-)
CAST/EiJ MGP_CASTEiJ_G0023699
 protein coding gene Chr18:61618326-61622169 (-)
CBA/J MGP_CBAJ_G0024196
 protein coding gene Chr18:66298766-66302610 (-)
DBA/2J MGP_DBA2J_G0024326
 protein coding gene Chr18:59521750-59525601 (-)
FVB/NJ MGP_FVBNJ_G0024292
 protein coding gene Chr18:58924843-58928694 (-)
LP/J MGP_LPJ_G0024410
 protein coding gene Chr18:62416415-62420266 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024321
 protein coding gene Chr18:67853048-67856899 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024952
 protein coding gene Chr18:61708226-61712077 (-)
PWK/PhJ MGP_PWKPhJ_G0023442
 protein coding gene Chr18:59757553-59761398 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023248
 protein coding gene Chr18:61937777-61941618 (-)
WSB/EiJ MGP_WSBEiJ_G0023763
 protein coding gene Chr18:61573829-61577680 (-)



Homology
more
  • Human Ortholog
    SPINK7, serine peptidase inhibitor Kazal type 7
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPINK7, serine peptidase inhibitor Kazal type 7
  • Synonyms
    ECG2, ECRG2
  • Links
    NCBI Gene ID: 84651
    neXtProt AC: NX_P58062
    UniProt: P58062

  • Chr Location
    5q32; chr5:148312419-148315922 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mcie homozygous for a null allele exhibit increased susceptibility to DSS-induced colitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000060201 Ensembl Gene Model | MGI Sequence Detail 4134 C57BL/6J ±  kb
    transcript ENSMUST00000076194 Ensembl | MGI Sequence Detail 540 Not Applicable  
    polypeptide ENSMUSP00000075551 Ensembl | MGI Sequence Detail 85 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less

    • Microarray probesets 1
    References
    more
    • Summaries
      All 15
      Gene Ontology 2
      Phenotypes 6
    • Earliest
      J:161922 Tang T, et al., A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol. 2010 Jul;28(7):749-55
    • Latest
      J:310883 Zhao N, et al., Neutrophils-derived Spink7 as one safeguard against experimental murine colitis. Biochim Biophys Acta Mol Basis Dis. 2021 Jun 1;1867(6):166125
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory