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C1s2
Gene Detail
 Symbol
Name
ID
C1s2
complement component 1, s subcomponent 2
MGI:3644269
Synonyms Gm5077
Feature Type protein coding gene
Genetic Map
Chromosome 6
59.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr6:124624625-124636085 bp, - strand
From VEGA annotation of GRCm38

  11461 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1314  Vertebrate Homology Class
1 human; 2 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: C1r-like complement-activating serine protease
Gene Tree: C1s2

Human
homologs
Human Homolog C1S, complement component 1, s subcomponent
NCBI Gene ID 716
neXtProt AC  NX_P09871
Human Chr (Location)  12p13; chr12:7060676-7071032 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human C1S
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
C1s2 interacts with 97 markers (Mir26a-2, Mir31, Mir34a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process complement activation, complement activation, classical pathway, ...
Component blood microparticle, extracellular region, ...
Function calcium ion binding, catalytic activity, ...
Expression
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(1) Other(1)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000028980 (Evidence)
Ensembl Gene ModelENSMUSG00000079343 (Evidence)
Entrez Gene317677 (Evidence)
UniGene483270
DFCITC1594565
DoTSDT.101390301
NIA Mouse Gene IndexU027843
EC3.4.21.42
Consensus CDS ProjectCCDS20522.2
International Mouse Knockout Project StatusC1s2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028980 VEGA Gene Model | MGI Sequence Detail 11461 C57BL/6J ±  kb
transcript OTTMUST00000071855 VEGA | MGI Sequence Detail 2662 Not Applicable 
polypeptide OTTMUSP00000036892 VEGA | MGI Sequence Detail 694 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(309 from dbSNP Build 137)    SNPs within 2kb including multiple locations(487)
Protein-related
information
ResourceIDDescription
InterPro IPR000859 CUB domain
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR024175 Peptidase S1A, complement C1r/C1S/mannan-binding
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR000436 Sushi/SCR/CCP
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000004898 complement C1s-B subcomponent
References (Earliest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(23)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory