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Ms4a4a Gene Detail
Summary
  • Symbol
    Ms4a4a
  • Name
    membrane-spanning 4-domains, subfamily A, member 4A
  • Synonyms
    EG666907
  • Feature Type
    protein coding gene
  • IDs
    MGI:3643932
    NCBI Gene: 666907
  • Member of
    Ms4ac cluster
  • Alliance
  • Transcription Start Sites
    34 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:11352887-11370154 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 8.44 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    85 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3643932
protein coding gene Chr19:11352827-11370682 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024877
protein coding gene Chr19:8757273-8782621 (+)
A/J MGP_AJ_G0024845
protein coding gene Chr19:8195380-8217976 (+)
AKR/J MGP_AKRJ_G0024820
protein coding gene Chr19:8505632-8524316 (+)
BALB/cJ MGP_BALBcJ_G0024845
protein coding gene Chr19:8231840-8249046 (+)
C3H/HeJ MGP_C3HHeJ_G0024611
protein coding gene Chr19:8391025-8409612 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025293
protein coding gene Chr19:9155879-9175282 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022720
protein coding gene Chr19:8595777-8614062 (+)
CAST/EiJ MGP_CASTEiJ_G0024084
protein coding gene Chr19:8025797-8051515 (+)
CBA/J MGP_CBAJ_G0024585
protein coding gene Chr19:9215392-9242435 (+)
DBA/2J MGP_DBA2J_G0024712
protein coding gene Chr19:8186309-8204764 (+)
FVB/NJ MGP_FVBNJ_G0024679
protein coding gene Chr19:8212281-8231474 (+)
LP/J MGP_LPJ_G0024799
protein coding gene Chr19:8724985-8742301 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024706
protein coding gene Chr19:9099079-9118268 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025341
protein coding gene Chr19:8533767-8551537 (+)
PWK/PhJ MGP_PWKPhJ_G0023828
protein coding gene Chr19:7634121-7652744 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023634
protein coding gene Chr19:7710440-7727755 (+)
WSB/EiJ MGP_WSBEiJ_G0024146
protein coding gene Chr19:8428153-8446853 (+)



Homology
more
  • Human Ortholog
    MS4A4A, membrane spanning 4-domains A4A
  • Vertebrate Orthologs
    9
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MS4A4A, membrane spanning 4-domains A4A
  • Synonyms
    4SPAN1, CD20L1, CD20-L1, HDCME31P, MS4A4, MS4A7
  • Links
    NCBI Gene ID: 51338
    neXtProt AC: NX_Q96JQ5
    UniProt: Q96JQ5

  • Chr Location
    11q12.2; chr11:60280541-60308972 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    1 phenotype reference
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show abnormal macrophage physiology and impaired eosinophil infiltration during lung allergic inflammation induced by intranasal administration of house dust mite.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000101389 Ensembl Gene Model | MGI Sequence Detail 17268 C57BL/6J ±  kb
transcript ENSMUST00000188995 Ensembl | MGI Sequence Detail 836 Not Applicable  
polypeptide ENSMUSP00000140768 Ensembl | MGI Sequence Detail 236 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR007237 CD20-like family
    IPR030417 Membrane-spanning 4-domains subfamily A
    IPR030425 Membrane-spanning 4-domains subfamily A member 4A
References
more
  • Summaries
    All 11
    Gene Ontology 2
    Phenotypes 1
  • Earliest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62
  • Latest
    J:296429 Sui Y, et al., MS4A4A Regulates Arginase 1 Induction during Macrophage Polarization and Lung Inflammation in Mice. Eur J Immunol. 2020 Oct;50(10):1602-1605

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory