Mylk4 MGI Mouse Gene Detail - MGI:3643758 - myosin light chain kinase family, member 4

Symbol

Mylk4
Name

myosin light chain kinase family, member 4
Synonyms

EG238564

Feature Type

protein coding gene
IDs

MGI:3643758
NCBI Gene: 238564
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr13:32884810-32967937 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 13.72 cM
Mapping Data

1 experiment

SNPs within 2kb

2484 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3643758	protein coding gene	Chr13:32884807-32967947 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020425	protein coding gene	Chr13:30698822-30786296 (-)
A/J	MGP_AJ_G0020380	protein coding gene	Chr13:29863056-29947488 (-)
AKR/J	MGP_AKRJ_G0020357	protein coding gene	Chr13:30516289-30607793 (-)
BALB/cJ	MGP_BALBcJ_G0020375	protein coding gene	Chr13:29948486-30032022 (-)
C3H/HeJ	MGP_C3HHeJ_G0020178	protein coding gene	Chr13:30505210-30592752 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020811	protein coding gene	Chr13:31728544-31821802 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018402	protein coding gene	Chr13:28187149-28268898 (-)
CAST/EiJ	MGP_CASTEiJ_G0019695	protein coding gene	Chr13:30219729-30325000 (-)
CBA/J	MGP_CBAJ_G0020134	protein coding gene	Chr13:33097455-33185461 (-)
DBA/2J	MGP_DBA2J_G0020256	protein coding gene	Chr13:29365632-29451676 (-)
FVB/NJ	MGP_FVBNJ_G0020241	protein coding gene	Chr13:28973298-29059997 (-)
LP/J	MGP_LPJ_G0020333	protein coding gene	Chr13:30904074-30987697 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020267	protein coding gene	Chr13:33156116-33249764 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020852	protein coding gene	Chr13:30163356-30250236 (-)
PWK/PhJ	MGP_PWKPhJ_G0019450	protein coding gene	Chr13:29548167-29637043 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019271	protein coding gene	Chr13:29091589-29179797 (-)
WSB/EiJ	MGP_WSBEiJ_G0019757	protein coding gene	Chr13:30485763-30572318 (-)

Human Ortholog

MYLK4, myosin light chain kinase family member 4

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MYLK4, myosin light chain kinase family member 4
Synonyms

SgK085
Links

HGNC:27972

NCBI Gene ID: 340156

UniProt: Q86YV6
Chr Location

6p25.2; chr6:2663629-2770376 (-) GRCh38

MGI Vertebrate Homology

Mylk4 stringent orthology
1 human;1 mouse;2 rat;2 zebrafish
HCOP

vertebrate homology predictions: MYLK4
Gene Tree

Mylk4

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Phenotype Summary

6 phenotypes from 3 alleles in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

3
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Mylk4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice show slightly decreased body weight and impaired muscle strength with decreased isometric torque and passive stiffness.

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All GO Annotations

15
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

4

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN mylk4b

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All Sequences

39
RefSeq

6
UniProt

4
CCDS

CCDS49225.1

Ensembl

ENSMUSG00000044951 (Evidence)
NCBI Gene

238564

			Length	Strain/Species	Flank
genomic	ENSMUSG00000044951	Ensembl Gene Model \| MGI Sequence Detail	83128	C57BL/6J	± kb
transcript	ENSMUST00000238977	Ensembl \| MGI Sequence Detail	6570	Not Applicable
polypeptide	ENSMUSP00000159085	Ensembl \| MGI Sequence Detail	667	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000029127 myosin light chain kinase family member 4

(term hierarchy)
InterPro Domains

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 4

cDNA 4

Microarray probesets 1

Summaries

All 32

Gene Ontology 6

Phenotypes 13
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mylk4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr122009	Chr13:32968008-32968025 (-)	-80 bp
Tssr122008	Chr13:32967977-32967990 (-)	-47 bp
Tssr122007	Chr13:32967940-32967958 (-)	-12 bp
Tssr122006	Chr13:32967917-32967929 (-)	14 bp
Tssr122005	Chr13:32967900-32967912 (-)	31 bp
Tssr122004	Chr13:32967886-32967897 (-)	45 bp
Tssr122003	Chr13:32960526-32960541 (-)	7,403 bp
Tssr122002	Chr13:32960447-32960460 (-)	7,483 bp
Tssr122001	Chr13:32960418-32960429 (-)	7,513 bp
Tssr122000	Chr13:32960379-32960408 (-)	7,543 bp
Tssr121999	Chr13:32887472-32887498 (-)	80,452 bp
Tssr121998	Chr13:32885690-32885709 (-)	82,237 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24