Mylk4 Gene Detail

Summary

• Symbol
  Mylk4
• Name
  myosin light chain kinase family, member 4
• Synonyms
  EG238564

• Feature Type
  protein coding gene
• IDs
  MGI:3643758
  NCBI Gene: 238564
• Alliance
  gene page

Location & Maps

• Sequence Map
  Chr13:32704680-32783954 bp, - strand
• From VEGA annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    79275 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 13, 13.72 cM
• Mapping Data
  1 experiment

Homology

• Human Ortholog
  MYLK4, myosin light chain kinase family member 4

• Vertebrate Orthologs
  10

• Human Ortholog
  MYLK4, myosin light chain kinase family member 4
  Orthology source: HomoloGene, HGNC
• Synonyms
  SgK085
• Links
  HGNC:27972

  NCBI Gene ID: 340156

  neXtProt AC: NX_Q86YV6

  UniProt: Q86YV6

  
  
• Chr Location
  6p25.2; chr6:2663629-2770330 (-)  GRCh38.p7

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• HomoloGene
  Vertebrate Homology Class 66243
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  
• HCOP
  human homology predictions: MYLK4
• Protein SuperFamily
  death-associated protein kinase 2
• Gene Tree
  Mylk4
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  10 phenotype references
  

• All Mutations and Alleles
  5
• Chemically induced (other)
  1
• Endonuclease-mediated
  1
• Radiation induced
  1
• Targeted
  2
• Genomic Mutations
  2 involving Mylk4
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  17 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  5
• GO References
  1

Expression

• cDNA Data
  4

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  ZFIN mylk4b

Interactions

• Mylk4 interacts with 391 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

Sequences &
Gene Models

• All Sequences
  25
• RefSeq
  10
• UniProt
  2
• CCDS
  CCDS49225.1
• UniGene
  60041

• VEGA
  OTTMUSG00000000690 (Evidence)
• Ensembl
  ENSMUSG00000044951 (Evidence)
• NCBI Gene
  238564

Representative Sequences			Length	Strain/Species
genomic	OTTMUSG00000000690	VEGA Gene Model | MGI Sequence Detail	79275	C57BL/6J
transcript	OTTMUST00000001322	VEGA | MGI Sequence Detail	1722	Not Applicable
polypeptide	OTTMUSP00000000621	VEGA | MGI Sequence Detail	386	Not Applicable

Polymorphisms

• SNPs within 2kb
  428 from dbSNP Build 142

Protein
Information

• UniProt
  2 Sequences
• InterPro Domains
  IPR017441 Protein kinase, ATP binding site
  IPR000719 Protein kinase domain
  IPR011009 Protein kinase-like domain superfamily
  IPR008271 Serine/threonine-protein kinase, active site

Molecular
Reagents

• All nucleic 4

  cDNA 4

  
  

  Microarray probesets 1

References

• Summaries
  All 23

  Gene Ontology 1

  Phenotypes 10
• Earliest
  J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
• Latest
  J:234274 Chang AN, et al., Cardiac myosin light chain is phosphorylated by Ca2+/calmodulin-dependent and -independent kinase activities. Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):E3824-33