About   Help   FAQ
Calhm1 Gene Detail
Summary
  • Symbol
    Calhm1
  • Name
    calcium homeostasis modulator 1
Location &
Maps
more
  • Sequence Map
    Chr19:47129474-47132613 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 39.36 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    219 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3643383
 protein coding gene Chr19:47129348-47132693 (-)
129S1/SvImJ ENSMUSG00200020382
 protein coding gene Chr19:43835551-43838880 (-)
A/J ENSMUSG00195016710
 protein coding gene Chr19:43966229-43969559 (-)
AKR/J ENSMUSG00220018631
 protein coding gene Chr19:43771337-43774679 (-)
BALB/cJ ENSMUSG00180017140
 protein coding gene Chr19:44218274-44221605 (-)
C3H/HeJ ENSMUSG00175006001
 protein coding gene Chr19:43764295-43767636 (-)
C57BL/6NJ ENSMUSG00215004691
 protein coding gene Chr19:43828096-43831441 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023052
 protein coding gene Chr19:43820068-43823129 (-)
CAST/EiJ ENSTCUG00005015339
 protein coding gene Chr19:43425515-43428809 (-)
CBA/J ENSMUSG00210018011
 protein coding gene Chr19:43843787-43847136 (-)
DBA/2J ENSMUSG00185008419
 protein coding gene Chr19:44341641-44344971 (-)
FVB/NJ ENSMUSG00205021869
 protein coding gene Chr19:43259590-43262930 (-)
JF1/MsJ ENSUMUG00000032865
 protein coding gene Chr19:44500780-44504067 (-)
LP/J ENSMUSG00230023915
 protein coding gene Chr19:45105133-45108462 (-)
NOD/ShiLtJ ENSMUSG00190004941
 protein coding gene Chr19:43708101-43711442 (-)
NZO/HlLtJ ENSMUSG00225043953
 protein coding gene Chr19:48700974-48704313 (-)
PWK/PhJ ENSLUMG00010001108
 protein coding gene Chr19:43667045-43670345 (-)
SPRET/EiJ ENSMSPG00010007312
 protein coding gene Chr19:43400444-43403668 (-)
WSB/EiJ ENSIUOG00005005898
 protein coding gene Chr19:43213144-43216467 (-)



Homology
more
  • Human Ortholog
    CALHM1, calcium homeostasis modulator 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CALHM1, calcium homeostasis modulator 1
  • Synonyms
    FAM26C
  • Links
    NCBI Gene ID: 255022
    UniProt: Q8IU99

  • Chr Location
    10q24.33; chr10:103453240-103458900 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 2 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit altered cortical neuron electrical properties.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    625
  • Tissues
    13
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 546729 NCBI Gene Model | MGI Sequence Detail 3140 C57BL/6J ±  kb
transcript NM_001081271 RefSeq | MGI Sequence Detail 1047 Not Specified  
polypeptide D3Z291 UniProt | EBI | MGI Sequence Detail 348 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 4
    Primer pair 2
    Other 2

    Microarray probesets 1
References
more
  • Summaries
    All 47
    Developmental Gene Expression 4
    Gene Ontology 12
    Phenotypes 26
  • Earliest
    J:186424 Ma Z, et al., Calcium homeostasis modulator 1 (CALHM1) is the pore-forming subunit of an ion channel that mediates extracellular Ca2+ regulation of neuronal excitability. Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):E1963-71
  • Latest
    J:368861 Landon SM, et al., Taste cells depend on axon proximity to generate presynaptic sites. PLoS One. 2025;20(6):e0325312
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory