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Calhm1 Gene Detail
Summary
  • Symbol
    Calhm1
  • Name
    calcium homeostasis modulator 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3643383
    NCBI Gene: 546729
  • Gene Overview
    MyGene.info: CALHM1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr19:47141035-47144174 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3140 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 39.36 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CALHM1, calcium homeostasis modulator 1
  • Vertebrate Orthologs
    12
  • Human Ortholog
    CALHM1, calcium homeostasis modulator 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FAM26C
  • Links
    NCBI Gene ID: 255022
    neXtProt AC: NX_Q8IU99
    UniProt: Q8IU99

  • Chr Location
    10q24.33; chr10:103453387-103458891 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 55508
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;2 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CALHM1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit altered cortical neuron electrical properties.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 546729 NCBI Gene Model | MGI Sequence Detail 3140 C57BL/6J ±  kb
transcript NM_001081271 RefSeq | MGI Sequence Detail 1047 Not Specified  
polypeptide D3Z291 UniProt | EBI | MGI Sequence Detail 348 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    73 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less

  • Microarray probesets 1
References
more
  • Summaries
    All 21
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:186424 Ma Z, et al., Calcium homeostasis modulator 1 (CALHM1) is the pore-forming subunit of an ion channel that mediates extracellular Ca2+ regulation of neuronal excitability. Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):E1963-71
  • Latest
    J:251041 Vingtdeux V, et al., CALHM1 deficiency impairs cerebral neuron activity and memory flexibility in mice. Sci Rep. 2016 Apr 12;6(None):24250

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
01/09/2018
MGI 6.11
The Jackson Laboratory